MD simulations of the translocation of Aβ1-42 through a sub-nanopore in silica are shown above. Visual molecular dynamics (VMD) snapshots are shown depicting three amino acid residues, arginine (R), aspartic acid (D) and glycine (G) translocating through a sub-nanopore. The sub-nanopore spanned a 4.0 nm thick membrane with a bi-conical topography defined by a cone angle of q1 = 10° and a 0.4 nm diameter at the waist. The pore is ghosted in the figure; only the water molecules, the peptide fragments and the Na+ (yellow/green) and Cl– (blue) ions are represented. -Courtesy of Archith Rayabharam and Narayana Aluru
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