{"id":31,"date":"2012-10-17T18:19:40","date_gmt":"2012-10-17T22:19:40","guid":{"rendered":"http:\/\/blogs.nd.edu\/hilllab\/?page_id=31"},"modified":"2017-08-16T14:03:51","modified_gmt":"2017-08-16T18:03:51","slug":"reginald-hill","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/hilllab\/people\/reginald-hill\/","title":{"rendered":"Reginald Hill"},"content":{"rendered":"

Reginald Hill, Ph.D.\"\"<\/a><\/strong>
\nArchibald Assistant Professor of Cancer Biology<\/em>
\nHarper Cancer Research Institute<\/a>
\nDepartment of Biological Sciences<\/a>
\nEmail: rhill3@nd.edu
\nTwitter: @Mousemodeler<\/a>
\nGoogle Scholar Profile<\/a><\/p>\n

Ph.D., Genetics and Molecular Biology<\/a>, University of North Carolina at Chapel Hill<\/p>\n

Postdoctoral Fellow, Medical and Molecular Pharmacology Dept<\/a>., UCLA<\/p>\n

My research interests are investigating the molecular mechanisms through which the microenvironment promotes tumor initiation, progression and therapeutic resistance.\u00a0<\/em><\/p>\n

My interest in elucidating the role of the microenvironment in tumorigenesis began with my graduate studies under Dr. Terry Van Dyke (UNC-Chapel Hill), where I designed and created a new transgenic mouse model of prostate cancer based on retinoblastoma gene (RB)<\/em> family inactivation.\u00a0 Interestingly, I uncovered that tumor initiation due to pRb family inactivation in the epithelium created selective pressure for p53<\/em> loss in the surrounding stromal cells, identifying a critical role for p53 in the mesenchyme. Most importantly, this stromal alteration aided further tumor progression.<\/p>\n

This underscored the importance of the microenvironment in tumor progression and supported the emerging concept of targeting the tumor microenvironment as a valid therapeutic strategy.<\/p>\n

As a Damon Runyon postdoctoral fellow<\/a> with Dr. Hong Wu (UCLA), I chose to focus on an area of research with a largely unmet need for translational research.\u00a0 Pancreatic cancer (PDAC) has a high mortality rate, dismal prognosis and few therapeutic options.\u00a0 This pointed to\u00a0a dire need for novel therapeutic and chemopreventative strategies, and for relevant research models of disease development.\u00a0 I played a central role in establishing mouse models based on PTEN loss of function that recapitulated human PDAC and worked to translate these findings to the human disease.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Reginald Hill, Ph.D. Archibald Assistant Professor of Cancer Biology Harper Cancer Research Institute Department of Biological Sciences Email: rhill3@nd.edu Twitter: @Mousemodeler Google Scholar Profile Ph.D., Genetics and Molecular Biology, University of North Carolina at Chapel Hill Postdoctoral Fellow, Medical and … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":932,"featured_media":0,"parent":9,"menu_order":1,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-31","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/pages\/31","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/users\/932"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/comments?post=31"}],"version-history":[{"count":20,"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/pages\/31\/revisions"}],"predecessor-version":[{"id":748,"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/pages\/31\/revisions\/748"}],"up":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/pages\/9"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/hilllab\/wp-json\/wp\/v2\/media?parent=31"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}