Publications

  1. Mahasenan, K. V., Ding, D., Gao M., Nguyen T. T., Suckow M. A., Schroeder V.A., Wolter W.R., Chang M., Mobashery S.. In Search of Selectivity in Inhibition of ADAM10. ACS Med. Chem. Lett. 2018, 9(7):708.
  2. Lee, M.; Batuecas, M. T.; Tomoshige, S.; Domínguez-Gil, T.; Mahasenan, K. V.; Dik, D. A.; Hesek, D.; Millán, C.; Usón, I.; Lastochkin, E.; Hermoso, J. A.; Mobashery, S. Exolytic and Endolytic Turnover of Peptidoglycan by Lytic Transglycosylase Slt of Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. U.S.A. 2018, 115(17):4393.
  3. Byun, B.; Mahasenan, K. V.; Dik, D. A.; Kumarasiri, M.; Fisher, J. F.; Hermoso, J. A.; and Mobashery, S. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. Sci Rep. 2018, 8(1):4110.
  4. Bernardo-Garcia, N.*; Mahasenan, K. V.*; Batuecas, M.; Lee, M.; Hesek, D; Petrácková, D.; Doubravová, L.; Branny, P.; Mobashery, S.; Hermoso, J.A. Allostery, Recognition of Nascent Peptidoglycan and Crosslinking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol. 2018,16;13(3):694. *equal contribution
  5. Acebrón,I.*; Mahasenan, K. V.*; De Benedetti, S.; Lee, M.; Artola-Recolons, C.; Hesek, D.; Wang, H.; Hermoso, J. A.; and Mobashery, S. Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. Am. Chem. Soc.; 2017 139(20):6795. *equal contribution.
  6. Mahasenan, K. V.; Bastian, M.; Gao, M.; Ding. D; Frost, E; Chang, M. F., Mobashery, S., Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. ACS Med. Chem. Lett., 2017, 8(6):654.
  7. Mahasenan, K. V., Molina, R., Bouley,, , Batuecas, M. T., Fisher, J. F., Hermoso, J. A., Chang, M., and Mobashery, S. Conformational dynamics and allosteric regulation of Penicillin-binding protein 2a in Methicillin-resistant Staphylococcus aureus. J. Am. Chem. Soc. 2017, 139(5):2102.
  8. Light, S. H., Cahoon, L. A., Mahasenan, K. V., Lee, M., Boggess, B., Halavaty, A. S., Mobashery, S. M., Freitag, N. E., Anderson, W. F. Transferase versus hydrolase: the role of conformational flexibility in reaction specificity. Structure. 2017, 25(2):295.
  9. Gao, M.; Zhang, H.; Trivedi, A.; Mahasenan, K. V.; Schroeder, V. A.; Wolter, W. R.; Suckow, M. A.; Mobashery, S.; Noble-Haeusslein, L. J.; Chang, M. Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery After Spinal Cord Injury. ACS Chem. Neurosci. 2016, 7(11):1482.
  10. Domínguez-Gil, T.; Lee, M.; Acebrón-Avalos, I; Mahasenan, K. V.; Hesek, D.; Dik, D.; Byun, B. J.; Lastochkin, E.; Fisher, J. F.; Mobashery, S.; Hermoso, J. A. Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa, Structure 2016, 24(10):1729
  11. Lee, M.; Domínguez-Gil, T.; Hesek, D.; Mahasenan, K. V.; Lastochkin, E.; Hermoso, J. A.; Mobashery, S. Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. ACS Chem. Biol. 2016;11(6):1525-31.
  12. Leemans,E.*; Mahasenan, K. V.*; Kumarasiri, M.; Ding, D.; O’Daniel, P.; Spink, E.; Boudreau, M. A.; Lastochkin, E.; Testero, S. A.; Yamaguchi, T.; Lee, M.; Hesek, D.; Fisher, J.; Chang, M.; and Mobashery, S. Three-Dimensional QSAR Analysis and Design of New 1,2,4-Oxadiazole Antibiotics; Med. Chem. Lett. 2016, 26(3):1011.*equal contribution.
  13. Alinari L*, Mahasenan K. V.*, Yan F* et al Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015, 125(16):2530. *equal contribution.
  14. Artola-Recolons, C.; Lee, M.; Bernardo-García, N.; Blázquez, B.; Hesek, D.; Bartual, S.; Mahasenan, K.V.; Lastochkin, E.; Pi, H.; Boggess, B.; Meindl, K.; Uson, I.; Fisher, J.; Mobashery, S.; Hermoso, J.; X-Ray Structure, Reactions and Evidence for Processivity in Catalysis by the Lytic Transglycosylase MltC of Escherichia coli.;
    ACS Chem. Biol. 2014;9(9):2058.
  15. Fu, H. L., Valiathan, R. R.; Payne, L.; Kumarasiri, M.;  Mahasenan K. V.; Mobashery, S.; Huang, P.; Fridman, R.; Glycosylation at ASN211 regulates the activation state of the discoidin domain receptor 1, Biol. Chem. 2014 28;289(13):9275.
  16. Gooyit, M.; Song, W.; Mahasenan, K. V.; Lichtenwalter, K; Suckow, M. A.; Schroeder, V. A.; Wolter, W. A.; Mobashery, M.; Chang, M.; O-Phenyl Carbamate and Phenyl Urea Thiiranes as Selective MMP-2 Inhibitors. Med. Chem. 2013,56 (20): 8139.
  17. Fu, H.; Valiathan, R. R.; Arkwright, R.; Sohail, A.; Mihai, C.; Kumarasiri, M.; Mahasenan, K. V.; Mobashery, S.; Huang, P.; Agarwal, G.; Fridman, R. Discoidin domain receptors: Unique receptor tyrosine kinases in collagen-mediated signaling. Biol. Chem. 2013, 288 (11):7430.
  18. Fu, H.; Sohail, A.; Valiathan, R. R. Wasinski, B. D.; Kumarasiri, M.; Mahasenan, K. V.; Bernardo, M. M; Tokmina-Roszyk, Dorota; Fields, G.B.; Mobashery, S.; and Fridman, R. Shedding of discoidin domain receptor (DDR) 1 by membrane type (MT)-matrix metalloproteinases (MMPs). Biol. Chem. 2013, 288 (17):12114.
  19. Endeshaw, M.; Zhu, X.; He, S.; Pandharkar, T.; Cason, E.; Mahasenan, K. V.; Agarwal, H.; Li, C.; Munde, M; Wilson, W. D.; Bahar,M.; Doskotch, R. W.; Kinghorn, A. D.; Kaiser, M.; Brun, R.; Drew, M. E.; and Werbovetz, K. A.; 8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity, Nat. Prod. 2013, 76 (3):311.
  20. Mahasenan, K. V.; Li, C. L. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a Maternal Embryonic Leucine Zipper Kinase Example, Chem. Inf. Model. 2012, 52 (5):1345.
  21. Dewan, V.; Liu, T.; Chen, K. M.; Qian, Z. Q.; Xiao, Y.; Kleiman, L.; Mahasenan, K. V.; Li, C. L.; Matsuo, H.; Pei, D. H.; Musier-Forsyth, K. Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction, ACS Chem. Biol. 2012, 7 (4):761.
  22. Mahasenan, K. V.; Pavlovicz, R. E.; Henderson, B. J.; Gonzalez-Cestari, T. F.; Yi, B. N.; McKay, D. B.; Li, C. L. Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening, ACS Med. Chem. Lett. 2011, 2 (11):
  23. Henderson, B. J.; Carper, D. J.; Gonzalez-Cestari, T. F.; Yi, B.; Mahasenan, K.; Pavlovicz, R. E.; Dalefield, M. L.; Coleman, R. S.; Li, C. L.; McKay, D. B. Structure-Activity Relationship Studies of Sulfonylpiperazine Analogues as Novel Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors, Med. Chem. 2011, 54 (24):8681.
  24. Fotie, J.; Kaiser, M.; Delfin, D. A.; Manley, J.; Reid, C. S.; Paris, J. M.; Wenzler, T.; Maes, L.; Mahasenan, K. V.; Li, C. L.; Werbovetz, K. A. Antitrypanosomal Activity of 1,2-Dihydroquinolin-6-ols and Their Ester Derivatives, Med. Chem. 2010, 53 (3):966.
  25. Tiwari, R.; Mahasenan, K.; Pavlovicz, R.; Li, C. L.; Tjarks, W. Carborane Clusters in Computational Drug Design: A Comparative Docking Evaluation Using AutoDock, FlexX, Glide, and Surflex, Chem. Inf. Model. 2009, 49 (6):1581.
  26. Kadam, R. U.; Tavares, J.; Kiran, V. M.; Cordeiro, A.; Ouaissi, A.; Roy, N. Structure function analysis of Leishmania sirtuin: An ensemble of In silico and biochemical studies, Biol. Drug. Des. 2008, 71(5):501.
  27. George, T. G.; Endeshaw, M. M.; Morgan, R. E.; Mahasenan, K. V.; Delfin, D. A.; Mukherjee, M. S.; Yakovich, A. J.; Fotie, J.; Li, C. L.; Werbovetz, K. A. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted N-1-phenyl-N-4,N-4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents, Med. Chem. 2007, 15 (18):6071.
  28. Kadam, R. U.; Kiran, V. M.; Roy, N. Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery, Med. Chem. Lett. 2006, 16 (23):6013.