{"id":6,"date":"2017-05-30T13:05:34","date_gmt":"2017-05-30T17:05:34","guid":{"rendered":"http:\/\/sites.nd.edu\/kiran-mahasenan\/?page_id=6"},"modified":"2018-09-11T10:34:22","modified_gmt":"2018-09-11T14:34:22","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/kiran-mahasenan\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
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  1. Mahasenan, K. V.,<\/strong> Ding, D., Gao M., Nguyen T. T., Suckow M. A., Schroeder V.A., Wolter W.R., Chang M., Mobashery S.. In Search of Selectivity in Inhibition of ADAM10. ACS Med. Chem. Lett.<\/em> 2018<\/strong>, 9(7):708.<\/li>\n
  2. Lee, M.; Batuecas, M. T.; Tomoshige, S.; Dom\u00ednguez-Gil,\u00a0T.; Mahasenan, K. V.<\/strong>; Dik, D. A.; Hesek,\u00a0D.; Mill\u00e1n,\u00a0C.; Us\u00f3n, I.; Lastochkin, E.; Hermoso, J. A.; Mobashery, S.\u00a0Exolytic and Endolytic Turnover of Peptidoglycan by Lytic Transglycosylase Slt of\u00a0Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. U.S.A.\u00a0<\/em>2018,<\/strong> 115(17):4393.<\/li>\n
  3. Byun, B.; Mahasenan, K. V.;<\/strong> Dik, D. A.; Kumarasiri, M.; Fisher, J. F.; Hermoso, J. A.; and Mobashery, S. Mechanism of the Escherichia coli<\/em> MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. Sci Rep.<\/em> 2018, <\/strong>8(1):4110.<\/li>\n
  4. Bernardo-Garcia, N.*; Mahasenan, K. V.*<\/strong><\/u>;<\/strong> Batuecas, M.; Lee, M.; Hesek, D; Petr\u00e1ckov\u00e1, D.; Doubravov\u00e1, L.; Branny, P.; Mobashery, S.; Hermoso, J.A. Allostery, Recognition of Nascent Peptidoglycan and Crosslinking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol. <\/em>2018<\/strong>,16;13(3):694.<\/em> *equal contribution<\/strong><\/li>\n
  5. Acebr\u00f3n,I.*; <\/u>Mahasenan, K. V.*<\/u><\/strong>; De Benedetti, S.; Lee, M.; Artola-Recolons, C.; Hesek, D.; Wang, H.; Hermoso, J. A.; and Mobashery, S. Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas<\/em> aeruginosa<\/em>. Am. Chem. Soc.<\/em>; 2017 <\/strong>139(20):6795. *equal contribution<\/strong>.<\/li>\n
  6. Mahasenan, K. V.<\/strong>; Bastian, M.; Gao, M.; Ding. D; Frost, E; Chang, M. F., Mobashery, S., Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. ACS Med. Chem. Lett.<\/em>,\u00a02017<\/strong>,\u00a08<\/em>(6):654.<\/li>\n
  7. Mahasenan, K. V.<\/strong>, Molina, R., Bouley,, <\/sup>, Batuecas, M. T., Fisher, J. F., Hermoso, J. A., Chang, M., and Mobashery, S. Conformational dynamics and allosteric regulation of Penicillin-binding protein 2a in Methicillin-resistant Staphylococcus aureus. J. Am. Chem. Soc. <\/em>2017<\/strong>, 139(5):2102<\/em>.<\/li>\n
  8. Light, S. H., Cahoon, L. A., Mahasenan, K. V.<\/strong>, Lee, M., Boggess, B., Halavaty, A. S., Mobashery, S. M., Freitag, N. E., Anderson, W. F. Transferase versus hydrolase: the role of conformational flexibility in reaction specificity. Structure<\/em>. 2017<\/strong>, 25(2):295.<\/li>\n
  9. Gao, M.; Zhang, H.; Trivedi, A.; Mahasenan, K. V.<\/strong>; Schroeder, V. A.; Wolter, W. R.; Suckow, M. A.; Mobashery, S.; Noble-Haeusslein, L. J.; Chang, M. Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery After Spinal Cord Injury. ACS Chem. Neurosci.<\/em> 2016<\/strong>, 7(11):1482.<\/li>\n
  10. Dom\u00ednguez-Gil, T.; Lee, M.; Acebr\u00f3n-Avalos, I; Mahasenan, K. V.<\/strong>; Hesek, D.; Dik, D.; Byun, B. J.; Lastochkin, E.; Fisher, J. F.; Mobashery, S.; Hermoso, J. A.\u00a0Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa<\/em>, Structure<\/em> 2016<\/strong>,\u00a024(10):1729<\/li>\n
  11. Lee, M.;\u00a0Dom\u00ednguez-Gil, T.; Hesek, D.; Mahasenan, K. V.<\/strong>; Lastochkin, E.; Hermoso, J. A.; Mobashery, S.\u00a0Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of\u00a0Pseudomonas aeruginosa.<\/em> ACS Chem. Biol<\/em>. 2016<\/strong>;11(6):1525-31.<\/li>\n
  12. Leemans,E.*; Mahasenan, K. V.*<\/strong>;<\/u> Kumarasiri, M.; Ding, D.; O\u2019Daniel, P.; Spink, E.; Boudreau, M. A.; Lastochkin, E.; Testero, S. A.; Yamaguchi, T.; Lee, M.; Hesek, D.; Fisher, J.; Chang, M.; and Mobashery, S. Three-Dimensional QSAR Analysis and Design of New 1,2,4-Oxadiazole Antibiotics; Med. Chem. Lett.<\/em> 2016<\/strong>, 26(3):1011.<\/em>*equal contribution<\/strong>.<\/li>\n
  13. Alinari L*, Mahasenan K. V.<\/strong>*,<\/u> Yan F* et al <\/em>Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood<\/em>. 2015<\/strong>, 125(16):2530. *equal contribution<\/strong>.<\/li>\n
  14. Artola-Recolons, C.; Lee, M.; Bernardo-Garc\u00eda, N.; Bl\u00e1zquez, B.; Hesek, D.; Bartual, S.; Mahasenan, K.V.<\/strong>; Lastochkin, E.; Pi, H.; Boggess, B.; Meindl, K.; Uson, I.; Fisher, J.; Mobashery, S.; Hermoso, J.; X-Ray Structure, Reactions and Evidence for Processivity in Catalysis by the Lytic Transglycosylase MltC of Escherichia coli.;
    \nACS Chem. Biol.<\/em> 2014<\/strong>;9(9):2058.<\/li>\n
  15. Fu, H. L., Valiathan, R. R.; Payne, L.; Kumarasiri, M.;\u00a0 Mahasenan K. V.<\/strong>; Mobashery, S.; Huang, P.; Fridman, R.; Glycosylation at ASN211 regulates the activation state of the discoidin domain receptor 1, Biol. Chem<\/em>. 2014<\/strong> 28;289(13):9275.<\/li>\n
  16. Gooyit, M.; Song, W.; Mahasenan, K. V.<\/strong>; Lichtenwalter, K; Suckow, M. A.; Schroeder, V. A.; Wolter, W. A.; Mobashery, M.; Chang, M.; O-Phenyl Carbamate and Phenyl Urea Thiiranes as Selective MMP-2 Inhibitors. Med. Chem. <\/em>2013<\/strong>,56<\/em>\u00a0(20): 8139.<\/li>\n
  17. Fu, H.; Valiathan, R. R.; Arkwright, R.; Sohail, A.; Mihai, C.; Kumarasiri, M.; Mahasenan, K. V<\/strong>.; Mobashery, S.; Huang, P.; Agarwal, G.; Fridman, R. Discoidin domain receptors: Unique receptor tyrosine kinases in collagen-mediated signaling. <\/em> Biol. Chem<\/em>.<\/em> 2013<\/strong>, 288 (11):7430.<\/li>\n
  18. Fu, H.; Sohail, A.; Valiathan, R. R. Wasinski, B. D.; Kumarasiri, M.; Mahasenan, K. V<\/strong>.; Bernardo, M. M; Tokmina-Roszyk, Dorota; Fields, G.B.; Mobashery, S.; and Fridman, R. Shedding of discoidin domain receptor (DDR) 1 by membrane type (MT)-matrix metalloproteinases (MMPs). Biol. Chem<\/em>.<\/em> 2013<\/strong>, 288 (17):12114.<\/li>\n
  19. Endeshaw, M.; Zhu, X.; He, S.; Pandharkar, T.; Cason, E.; Mahasenan, K. V<\/strong>.; Agarwal, H.; Li, C.; Munde, M; Wilson, W. D.; Bahar,M.; Doskotch, R. W.; Kinghorn, A. D.; Kaiser, M.; Brun, R.; Drew, M. E.; and Werbovetz, K. A.; 8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity, Nat. Prod<\/em>.<\/em> 2013<\/strong>, 76 (3):311.<\/li>\n
  20. Mahasenan, K. V<\/strong>.; Li, C. L. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a Maternal Embryonic Leucine Zipper Kinase Example, Chem. Inf. Model.<\/em> 2012<\/strong>, 52 (5):1345.<\/li>\n
  21. Dewan, V.; Liu, T.; Chen, K. M.; Qian, Z. Q.; Xiao, Y.; Kleiman, L.; Mahasenan, K. V<\/strong>.; Li, C. L.; Matsuo, H.; Pei, D. H.; Musier-Forsyth, K. Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction, ACS Chem. Biol.<\/em> 2012<\/strong>, 7 (4):761.<\/li>\n
  22. Mahasenan, K. V<\/strong>.; Pavlovicz, R. E.; Henderson, B. J.; Gonzalez-Cestari, T. F.; Yi, B. N.; McKay, D. B.; Li, C. L. Discovery of Novel \u03b14\u03b22 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening, ACS Med. Chem. Lett.<\/em> 2011<\/strong>, 2 (11):<\/li>\n
  23. Henderson, B. J.; Carper, D. J.; Gonzalez-Cestari, T. F.; Yi, B.; Mahasenan, K<\/strong>.; Pavlovicz, R. E.; Dalefield, M. L.; Coleman, R. S.; Li, C. L.; McKay, D. B. Structure-Activity Relationship Studies of Sulfonylpiperazine Analogues as Novel Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors, Med. Chem.<\/em> 2011<\/strong>, 54 (24):8681.<\/li>\n
  24. Fotie, J.; Kaiser, M.; Delfin, D. A.; Manley, J.; Reid, C. S.; Paris, J. M.; Wenzler, T.; Maes, L.; Mahasenan, K. V<\/strong>.; Li, C. L.; Werbovetz, K. A. Antitrypanosomal Activity of 1,2-Dihydroquinolin-6-ols and Their Ester Derivatives, Med. Chem.<\/em> 2010<\/strong>, 53 (3):966.<\/li>\n
  25. Tiwari, R.; Mahasenan, K.; Pavlovicz, R.; Li, C. L.; Tjarks, W. Carborane Clusters in Computational Drug Design: A Comparative Docking Evaluation Using AutoDock, FlexX, Glide, and Surflex, Chem. Inf. Model.<\/em> 2009<\/strong>, 49 (6):1581.<\/li>\n
  26. Kadam, R. U.; Tavares, J.; Kiran, V. M<\/strong>.; Cordeiro, A.; Ouaissi, A.; Roy, N. Structure function analysis of Leishmania sirtuin: An ensemble of In silico and biochemical studies, Biol. Drug. Des.<\/em> 2008<\/strong>, 71(5):501.<\/li>\n
  27. George, T. G.; Endeshaw, M. M.; Morgan, R. E.; Mahasenan, K. V<\/strong>.; Delfin, D. A.; Mukherjee, M. S.; Yakovich, A. J.; Fotie, J.; Li, C. L.; Werbovetz, K. A. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted N-1-phenyl-N-4,N-4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents, Med. Chem.<\/em> 2007<\/strong>, 15 (18):6071.<\/li>\n
  28. Kadam, R. U.; Kiran, V. M<\/strong>.; Roy, N. Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery, Med. Chem. Lett.<\/em> 2006<\/strong>, 16 (23):6013.<\/li>\n<\/ol>\n

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    Mahasenan, K. V., Ding, D., Gao M., Nguyen T. T., Suckow M. A., Schroeder V.A., Wolter W.R., Chang M., Mobashery S.. In Search of Selectivity in Inhibition of ADAM10. ACS Med. Chem. Lett. 2018, 9(7):708. Lee, M.; Batuecas, M. T.; … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2614,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"yoast_head":"\nPublications - Kiran Mahasenan, PhD<\/title>\n<meta name=\"description\" content=\"List if publications of Dr. Kiran Mahasenan PhD\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.nd.edu\/kiran-mahasenan\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Kiran Mahasenan, PhD\" \/>\n<meta property=\"og:description\" content=\"List if publications of Dr. Kiran Mahasenan PhD\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.nd.edu\/kiran-mahasenan\/publications\/\" \/>\n<meta property=\"og:site_name\" content=\"Kiran Mahasenan, PhD\" \/>\n<meta property=\"article:modified_time\" content=\"2018-09-11T14:34:22+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/kiran-mahasenan\\\/publications\\\/\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/kiran-mahasenan\\\/publications\\\/\",\"name\":\"Publications - 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