Publications

2024

• Li M, Li J. Steroids in Cancer: Mechanisms, Therapies, and Challenges in Hormone-Driven Malignancies. In: Nima R, editor. Interdisciplinary Cancer Research [Internet] 10.1007/16833_2024_294: Springer Nature; 2024. Available from: https://link.springer.com/10.1007/16833_2024_294.

2023-2009

• Cui D, Li J, Zhu Z, Berk M, Hardaway A, McManus J, Chung YM, Alyamani M, Valle S, Tiwari R, Han B, Goudarzi M, Willard B, Sharifi N. Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation. J Clin Invest. 2023 Apr 3;133(7). doi: 10.1172/JCI161913. PubMed PMID: 37009898; PubMed Central PMCID: PMC10065083.
• Hardaway AL, Goodarzi M, Berk M, Li J, Chung YM, Sharifi N. Response to “Letter to the Editor From Penning and Deltefsen “5-hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells”. Endocrinology. 2023 Mar 13;164(5). doi: 10.1210/endocr/bqad053. PubMed PMID: 36951302.
• Hardaway AL, Goudarzi M, Berk M, Chung YM, Zhang R, Li J, Klein E, Sharifi N. 5-Hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells. Endocrinology. 2022 Nov 14;164(1). doi: 10.1210/endocr/bqac191. PubMed PMID: 36412122; PubMed Central PMCID: PMC9923800.
• Baratchian M, Tiwari R, Khalighi S, Chakravarthy A, Yuan W, Berk M, Li J, Guerinot A, de Bono J, Makarov V, Chan TA, Silverman RH, Stark GR, Varadan V, De Carvalho DD, Chakraborty AA, Sharifi N. H3K9 methylation drives resistance to androgen receptor-antagonist therapy in prostate cancer. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2114324119. doi: 10.1073/pnas.2114324119. Epub 2022 May 18. PubMed PMID: 35584120; PubMed Central PMCID: PMC9173765.
• Li J, Berk M, Alyamani M, Sabharwal N, Goins C, Alvarado J, Baratchian M, Zhu Z, Stauffer S, Klein EA, Sharifi N. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13(595). doi: 10.1126/scitranslmed.abe8226. PubMed PMID: 34039740; PubMed Central PMCID: PMC8319670.
• Zhu Z, Chung YM, Sergeeva O, Kepe V, Berk M, Li J, Ko HK, Li Z, Petro M, DiFilippo FP, Lee Z, Sharifi N. Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging. J Biol Chem. 2018 Nov 16;293(46):17829-17837. doi: 10.1074/jbc.RA118.004846. Epub 2018 Sep 27. PubMed PMID: 30262668; PubMed Central PMCID: PMC6240862.
• Gao X, Dai C, Huang S, Tang J, Chen G, Li J, Zhu Z, Zhu X, Zhou S, Gao Y, Hou Z, Fang Z, Xu C, Wang J, Wu D, Sharifi N, Li Z. Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression. Clin Cancer Res. 2019 Feb 15;25(4):1291-1301. doi: 10.1158/1078-0432.CCR-18-2392. Epub 2018 Sep 18. PubMed PMID: 30228209; PubMed Central PMCID: PMC6377858.
• Dai C, Chung YM, Kovac E, Zhu Z, Li J, Magi-Galluzzi C, Stephenson AJ, Klein EA, Sharifi N. Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues. Clin Cancer Res. 2017 Oct 15;23(20):6351-6362. doi: 10.1158/1078-0432.CCR-17-1313. Epub 2017 Jul 21. PubMed PMID: 28733443; PubMed Central PMCID: PMC5641243.
• Alyamani M, Li Z, Berk M, Li J, Tang J, Upadhyay S, Auchus RJ, Sharifi N. Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities. Cell Chem Biol. 2017 Jul 20;24(7):825-832.e6. doi: 10.1016/j.chembiol.2017.05.020. Epub 2017 Jun 22. PubMed PMID: 28648378; PubMed Central PMCID: PMC5533090.
• Li J, Alyamani M, Zhang A, Chang KH, Berk M, Li Z, Zhu Z, Petro M, Magi-Galluzzi C, Taplin ME, Garcia JA, Courtney K, Klein EA, Sharifi N. Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide-resistant prostate cancer. Elife. 2017 Feb 13;6. doi: 10.7554/eLife.20183. PubMed PMID: 28191869; PubMed Central PMCID: PMC5305204.
• Li Z, Alyamani M, Li J, Rogacki K, Abazeed M, Upadhyay SK, Balk SP, Taplin ME, Auchus RJ, Sharifi N. Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy. Nature. 2016 May 26;533(7604):547-51. doi: 10.1038/nature17954. PubMed PMID: 27225130; PubMed Central PMCID: PMC5111629.
• Shu Q, Li W, Li J, Wang W, Liu C, Sun K. Cross-talk between cAMP and MAPK pathways in HSD11B2 induction by hCG in placental trophoblasts. PLoS One. 2014;9(9):e107938. doi: 10.1371/journal.pone.0107938. eCollection 2014. PubMed PMID: 25229504; PubMed Central PMCID: PMC4168233.
• Wu J, Li J, Xu MH, Liu D. Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3050-6. doi: 10.1016/j.bmcl.2014.05.028. Epub 2014 May 20. PubMed PMID: 24880902.
• Wang WS, Liu C, Li WJ, Zhu P, Li JN, Sun K. Involvement of CRH and hCG in the induction of aromatase by cortisol in human placental syncytiotrophoblasts. Placenta. 2014 Jan;35(1):30-6. doi: 10.1016/j.placenta.2013.10.018. Epub 2013 Nov 7. PubMed PMID: 24239159.
• Li J, Wang W, Liu C, Wang W, Li W, Shu Q, Chen ZJ, Sun K. Critical role of histone acetylation by p300 in human placental 11β-HSD2 expression. J Clin Endocrinol Metab. 2013 Jul;98(7):E1189-97. doi: 10.1210/jc.2012-4291. Epub 2013 May 28. PubMed PMID: 23714681.
• Wu J, Zhang D, Chen L, Li J, Wang J, Ning C, Yu N, Zhao F, Chen D, Chen X, Chen K, Jiang H, Liu H, Liu D. Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. J Med Chem. 2013 Feb 14;56(3):761-80. doi: 10.1021/jm301032j. Epub 2013 Jan 28. PubMed PMID: 23316803.
• Wang W, Guo C, Li W, Li J, Wang W, Myatt L, Sun K. Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts. Endocrinology. 2012 Dec;153(12):5993-6002. doi: 10.1210/en.2012-1531. Epub 2012 Nov 2. PubMed PMID: 23125313; PubMed Central PMCID: PMC3512073.
• Wang W, Li J, Ge Y, Li W, Shu Q, Guan H, Yang K, Myatt L, Sun K. Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP/Sp1 pathway. Endocrinology. 2012 Apr;153(4):2012-22. doi: 10.1210/en.2011-1626. Epub 2012 Feb 7. PubMed PMID: 22315456.
• Ge YC, Li JN, Ni XT, Guo CM, Wang WS, Duan T, Sun K. Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts. Reproduction. 2011 Aug;142(2):369-75. doi: 10.1530/REP-11-0053. Epub 2011 May 11. PubMed PMID: 21562093.
• Li JN, Ge YC, Yang Z, Guo CM, Duan T, Myatt L, Guan H, Yang K, Sun K. The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts. J Clin Endocrinol Metab. 2011 Jun;96(6):E899-907. doi: 10.1210/jc.2010-2852. Epub 2011 Mar 16. PubMed PMID: 21411560.select
• Guo C, Li J, Myatt L, Zhu X, Sun K. Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. Mol Endocrinol. 2010 May;24(5):1052-61. doi: 10.1210/me.2009-0488. Epub 2010 Mar 4. PubMed PMID: 20203101; PubMed Central PMCID: PMC5417499.select
• Ni XT, Duan T, Yang Z, Guo CM, Li JN, Sun K. Role of human chorionic gonadotropin in maintaining 11beta-hydroxysteroid dehydrogenase type 2 expression in human placental syncytiotrophoblasts. Placenta. 2009 Dec;30(12):1023-8. doi: 10.1016/j.placenta.2009.10.005. Epub 2009 Oct 31. PubMed PMID: 19880179.select
• Zhu XO, Yang Z, Guo CM, Ni XT, Li JN, Ge YC, Myatt L, Sun K. Paradoxical stimulation of cyclooxygenase-2 expression by glucocorticoids via a cyclic AMP response element in human amnion fibroblasts. Mol Endocrinol. 2009 Nov;23(11):1839-49. doi: 10.1210/me.2009-0201. Epub 2009 Oct 1. PubMed PMID: 19797430; PubMed Central PMCID: PMC5419155.