{"id":39,"date":"2026-03-01T15:54:41","date_gmt":"2026-03-01T15:54:41","guid":{"rendered":"https:\/\/sites.nd.edu\/lilab\/?page_id=39"},"modified":"2026-09-21T22:52:19","modified_gmt":"2026-09-21T22:52:19","slug":"publication","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/lilab\/publication\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\" style=\"font-size:26px\"><strong>2026<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:18px\">Adams S, Phelan L, Lewis T, Behm J, Law A, Shi X, Li G, Li J. 5\u03b2-Dihydrotestosterone reveals a mutant androgen receptor vulnerability in prostate cancer. bioRxiv [Preprint]. 2026 July. Available from: <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.07.14.738538v1.\">https:\/\/www.biorxiv.org\/content\/10.64898\/2026.07.14.738538v1.<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:26px\"><strong>2025<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:18px\">Zhu Z, Chung YM, Alyamani M, Dai Y, McCarty KD, Roberts E, Sinha S, <strong>Li J<\/strong>, Li X, Gad EM, Zhou Z, Shi J, Burgess RA, Hargrove TY, Lepesheva GI, Guengerich FP, Auchus RJ, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41345099\/\" target=\"_blank\" rel=\"noreferrer noopener\">A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1.&nbsp;<\/a>Nat Commun.&nbsp;2025 Dec 4;16(1):10611.&nbsp;doi: 10.1038\/s41467-025-66558-2.&nbsp;PubMed PMID: 41345099; PubMed Central PMCID: PMC12678803.<\/li>\n\n\n\n<li style=\"font-size:18px\">Sands M, Adams S, Lee J, Li M, Wang M, Walsh T Jr, Leon L, Zablah A, Haerens M, Liu Z,<strong>Li J.<\/strong>&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41058763\/\" target=\"_blank\" rel=\"noreferrer noopener\">The interconnection between androgen receptor and DNA damage response pathways in prostate cancer.&nbsp;<\/a>Curr Urol.&nbsp;2025 Nov;19(6):376-387.&nbsp;doi: 10.1097\/CU9.0000000000000300.&nbsp;Epub 2025 Aug 18.&nbsp;Review.&nbsp;PubMed PMID: 41058763; PubMed Central PMCID: PMC12499796.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\" style=\"font-size:26px\"><strong>2024<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:18px\">Li M, <strong>Li J.<\/strong>&nbsp;Steroids in Cancer: Mechanisms, Therapies, and Challenges in Hormone-Driven Malignancies.&nbsp;In:&nbsp;Nima R, editor.&nbsp;Interdisciplinary Cancer Research [Internet]&nbsp;10.1007\/16833_2024_294: Springer Nature;&nbsp;2024.&nbsp;Available from: https:\/\/link.springer.com\/10.1007\/16833_2024_294.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:26px\"><strong>2023-2009<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:18px\">Cui D, <strong>Li J,<\/strong> Zhu Z, Berk M, Hardaway A, McManus J, Chung YM, Alyamani M, Valle S, Tiwari R, Han B, Goudarzi M, Willard B, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37009898\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation.&nbsp;<\/a>J Clin Invest.&nbsp;2023 Apr 3;133(7).&nbsp;doi: 10.1172\/JCI161913.&nbsp;PubMed PMID: 37009898; PubMed Central PMCID: PMC10065083.<\/li>\n\n\n\n<li style=\"font-size:18px\">Hardaway AL, Goodarzi M, Berk M, <strong>Li J,<\/strong> Chung YM, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36951302\/\" target=\"_blank\" rel=\"noreferrer noopener\">Response to &#8220;Letter to the Editor From Penning and Deltefsen &#8220;5-hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells&#8221;.&nbsp;<\/a>Endocrinology.&nbsp;2023 Mar 13;164(5).&nbsp;doi: 10.1210\/endocr\/bqad053.&nbsp;PubMed PMID: 36951302.<\/li>\n\n\n\n<li style=\"font-size:18px\">Hardaway AL, Goudarzi M, Berk M, Chung YM, Zhang R, <strong>Li J,<\/strong> Klein E, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36412122\/\" target=\"_blank\" rel=\"noreferrer noopener\">5-Hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells.&nbsp;<\/a>Endocrinology.&nbsp;2022 Nov 14;164(1).&nbsp;doi: 10.1210\/endocr\/bqac191.&nbsp;PubMed PMID: 36412122; PubMed Central PMCID: PMC9923800.<\/li>\n\n\n\n<li style=\"font-size:18px\">Baratchian M, Tiwari R, Khalighi S, Chakravarthy A, Yuan W, Berk M, <strong>Li J,<\/strong> Guerinot A, de Bono J, Makarov V, Chan TA, Silverman RH, Stark GR, Varadan V, De Carvalho DD, Chakraborty AA, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35584120\/\" target=\"_blank\" rel=\"noreferrer noopener\">H3K9 methylation drives resistance to androgen receptor-antagonist therapy in prostate cancer.&nbsp;<\/a>Proc Natl Acad Sci U S A.&nbsp;2022 May 24;119(21):e2114324119.&nbsp;doi: 10.1073\/pnas.2114324119.&nbsp;Epub 2022 May 18.&nbsp;PubMed PMID: 35584120; PubMed Central PMCID: PMC9173765.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li J,<\/strong> Berk M, Alyamani M, Sabharwal N, Goins C, Alvarado J, Baratchian M, Zhu Z, Stauffer S, Klein EA, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34039740\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation.&nbsp;<\/a>Sci Transl Med.&nbsp;2021 May 26;13(595).&nbsp;doi: 10.1126\/scitranslmed.abe8226.&nbsp;PubMed PMID: 34039740; PubMed Central PMCID: PMC8319670.<\/li>\n\n\n\n<li style=\"font-size:18px\">Zhu Z, Chung YM, Sergeeva O, Kepe V, Berk M, <strong>Li J,<\/strong> Ko HK, Li Z, Petro M, DiFilippo FP, Lee Z, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30262668\/\" target=\"_blank\" rel=\"noreferrer noopener\">Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging.&nbsp;<\/a>J Biol Chem.&nbsp;2018 Nov 16;293(46):17829-17837.&nbsp;doi: 10.1074\/jbc.RA118.004846.&nbsp;Epub 2018 Sep 27.&nbsp;PubMed PMID: 30262668; PubMed Central PMCID: PMC6240862.<\/li>\n\n\n\n<li style=\"font-size:18px\">Gao X, Dai C, Huang S, Tang J, Chen G, <strong>Li J,<\/strong> Zhu Z, Zhu X, Zhou S, Gao Y, Hou Z, Fang Z, Xu C, Wang J, Wu D, Sharifi N, Li Z.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30228209\/\" target=\"_blank\" rel=\"noreferrer noopener\">Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression.&nbsp;<\/a>Clin Cancer Res.&nbsp;2019 Feb 15;25(4):1291-1301.&nbsp;doi: 10.1158\/1078-0432.CCR-18-2392.&nbsp;Epub 2018 Sep 18.&nbsp;PubMed PMID: 30228209; PubMed Central PMCID: PMC6377858.<\/li>\n\n\n\n<li style=\"font-size:18px\">Dai C, Chung YM, Kovac E, Zhu Z, <strong>Li J,<\/strong> Magi-Galluzzi C, Stephenson AJ, Klein EA, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28733443\/\" target=\"_blank\" rel=\"noreferrer noopener\">Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues.&nbsp;<\/a>Clin Cancer Res.&nbsp;2017 Oct 15;23(20):6351-6362.&nbsp;doi: 10.1158\/1078-0432.CCR-17-1313.&nbsp;Epub 2017 Jul 21.&nbsp;PubMed PMID: 28733443; PubMed Central PMCID: PMC5641243.<\/li>\n\n\n\n<li style=\"font-size:18px\">Alyamani M, Li Z, Berk M, <strong>Li J,<\/strong> Tang J, Upadhyay S, Auchus RJ, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28648378\/\" target=\"_blank\" rel=\"noreferrer noopener\">Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities.&nbsp;<\/a>Cell Chem Biol.&nbsp;2017 Jul 20;24(7):825-832.e6.&nbsp;doi: 10.1016\/j.chembiol.2017.05.020.&nbsp;Epub 2017 Jun 22.&nbsp;PubMed PMID: 28648378; PubMed Central PMCID: PMC5533090.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li J,<\/strong> Alyamani M, Zhang A, Chang KH, Berk M, Li Z, Zhu Z, Petro M, Magi-Galluzzi C, Taplin ME, Garcia JA, Courtney K, Klein EA, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28191869\/\" target=\"_blank\" rel=\"noreferrer noopener\">Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide-resistant prostate cancer.&nbsp;<\/a>Elife.&nbsp;2017 Feb 13;6.&nbsp;doi: 10.7554\/eLife.20183.&nbsp;PubMed PMID: 28191869; PubMed Central PMCID: PMC5305204.<\/li>\n\n\n\n<li style=\"font-size:18px\">Li Z, Alyamani M, <strong>Li J,<\/strong> Rogacki K, Abazeed M, Upadhyay SK, Balk SP, Taplin ME, Auchus RJ, Sharifi N.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27225130\/\" target=\"_blank\" rel=\"noreferrer noopener\">Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy.&nbsp;<\/a>Nature.&nbsp;2016 May 26;533(7604):547-51.&nbsp;doi: 10.1038\/nature17954.&nbsp;PubMed PMID: 27225130; PubMed Central PMCID: PMC5111629.<\/li>\n\n\n\n<li style=\"font-size:18px\">Shu Q, Li W, <strong>Li J,<\/strong> Wang W, Liu C, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25229504\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cross-talk between cAMP and MAPK pathways in HSD11B2 induction by hCG in placental trophoblasts.&nbsp;<\/a>PLoS One.&nbsp;2014;9(9):e107938.&nbsp;doi: 10.1371\/journal.pone.0107938.&nbsp;eCollection 2014.&nbsp;PubMed PMID: 25229504; PubMed Central PMCID: PMC4168233.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wu J, <strong>Li J,<\/strong> Xu MH, Liu D.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24880902\/\" target=\"_blank\" rel=\"noreferrer noopener\">Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole.&nbsp;<\/a>Bioorg Med Chem Lett.&nbsp;2014 Jul 15;24(14):3050-6.&nbsp;doi: 10.1016\/j.bmcl.2014.05.028.&nbsp;Epub 2014 May 20.&nbsp;PubMed PMID: 24880902.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wang WS, Liu C, Li WJ, Zhu P, <strong>Li JN,<\/strong> Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24239159\/\" target=\"_blank\" rel=\"noreferrer noopener\">Involvement of CRH and hCG in the induction of aromatase by cortisol in human placental syncytiotrophoblasts.&nbsp;<\/a>Placenta.&nbsp;2014 Jan;35(1):30-6.&nbsp;doi: 10.1016\/j.placenta.2013.10.018.&nbsp;Epub 2013 Nov 7.&nbsp;PubMed PMID: 24239159.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li J,<\/strong> Wang W, Liu C, Wang W, Li W, Shu Q, Chen ZJ, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23714681\/\" target=\"_blank\" rel=\"noreferrer noopener\">Critical role of histone acetylation by p300 in human placental 11\u03b2-HSD2 expression.&nbsp;<\/a>J Clin Endocrinol Metab.&nbsp;2013 Jul;98(7):E1189-97.&nbsp;doi: 10.1210\/jc.2012-4291.&nbsp;Epub 2013 May 28.&nbsp;PubMed PMID: 23714681.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wu J, Zhang D, Chen L, <strong>Li J,<\/strong> Wang J, Ning C, Yu N, Zhao F, Chen D, Chen X, Chen K, Jiang H, Liu H, Liu D.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23316803\/\" target=\"_blank\" rel=\"noreferrer noopener\">Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.&nbsp;<\/a>J Med Chem.&nbsp;2013 Feb 14;56(3):761-80.&nbsp;doi: 10.1021\/jm301032j.&nbsp;Epub 2013 Jan 28.&nbsp;PubMed PMID: 23316803.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wang W, Guo C, Li W, <strong>Li J,<\/strong> Wang W, Myatt L, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23125313\/\" target=\"_blank\" rel=\"noreferrer noopener\">Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts.&nbsp;<\/a>Endocrinology.&nbsp;2012 Dec;153(12):5993-6002.&nbsp;doi: 10.1210\/en.2012-1531.&nbsp;Epub 2012 Nov 2.&nbsp;PubMed PMID: 23125313; PubMed Central PMCID: PMC3512073.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wang W, <strong>Li J,<\/strong> Ge Y, Li W, Shu Q, Guan H, Yang K, Myatt L, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22315456\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP\/Sp1 pathway.&nbsp;<\/a>Endocrinology.&nbsp;2012 Apr;153(4):2012-22.&nbsp;doi: 10.1210\/en.2011-1626.&nbsp;Epub 2012 Feb 7.&nbsp;PubMed PMID: 22315456.<\/li>\n\n\n\n<li style=\"font-size:18px\">Ge YC, <strong>Li JN,<\/strong> Ni XT, Guo CM, Wang WS, Duan T, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21562093\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts.&nbsp;<\/a>Reproduction.&nbsp;2011 Aug;142(2):369-75.&nbsp;doi: 10.1530\/REP-11-0053.&nbsp;Epub 2011 May 11.&nbsp;PubMed PMID: 21562093.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li JN,<\/strong> Ge YC, Yang Z, Guo CM, Duan T, Myatt L, Guan H, Yang K, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21411560\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts.&nbsp;<\/a>J Clin Endocrinol Metab.&nbsp;2011 Jun;96(6):E899-907.&nbsp;doi: 10.1210\/jc.2010-2852.&nbsp;Epub 2011 Mar 16.&nbsp;PubMed PMID: 21411560.select<\/li>\n\n\n\n<li style=\"font-size:18px\">Guo C, <strong>Li J,<\/strong> Myatt L, Zhu X, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20203101\/\" target=\"_blank\" rel=\"noreferrer noopener\">Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts.&nbsp;<\/a>Mol Endocrinol.&nbsp;2010 May;24(5):1052-61.&nbsp;doi: 10.1210\/me.2009-0488.&nbsp;Epub 2010 Mar 4.&nbsp;PubMed PMID: 20203101; PubMed Central PMCID: PMC5417499.select<\/li>\n\n\n\n<li style=\"font-size:18px\">Ni XT, Duan T, Yang Z, Guo CM, <strong>Li JN,<\/strong> Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19880179\/\" target=\"_blank\" rel=\"noreferrer noopener\">Role of human chorionic gonadotropin in maintaining 11beta-hydroxysteroid dehydrogenase type 2 expression in human placental syncytiotrophoblasts.&nbsp;<\/a>Placenta.&nbsp;2009 Dec;30(12):1023-8.&nbsp;doi: 10.1016\/j.placenta.2009.10.005.&nbsp;Epub 2009 Oct 31.&nbsp;PubMed PMID: 19880179.select<\/li>\n\n\n\n<li style=\"font-size:18px\">Zhu XO, Yang Z, Guo CM, Ni XT, <strong>Li JN,<\/strong> Ge YC, Myatt L, Sun K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19797430\/\" target=\"_blank\" rel=\"noreferrer noopener\">Paradoxical stimulation of cyclooxygenase-2 expression by glucocorticoids via a cyclic AMP response element in human amnion fibroblasts.&nbsp;<\/a>Mol Endocrinol.&nbsp;2009 Nov;23(11):1839-49.&nbsp;doi: 10.1210\/me.2009-0201.&nbsp;Epub 2009 Oct 1.&nbsp;PubMed PMID: 19797430; PubMed Central PMCID: PMC5419155.<\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>2026 2025 2024 2023-2009<\/p>\n","protected":false},"author":5239,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"[]"},"class_list":["post-39","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/users\/5239"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":4,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":266,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages\/39\/revisions\/266"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}