{"id":39,"date":"2026-03-01T15:54:41","date_gmt":"2026-03-01T15:54:41","guid":{"rendered":"https:\/\/sites.nd.edu\/lilab\/?page_id=39"},"modified":"2026-03-12T18:31:50","modified_gmt":"2026-03-12T18:31:50","slug":"publication","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/lilab\/publication\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<p style=\"font-size:26px\"><strong>2025<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:18px\">Zhu Z, Chung YM, Alyamani M, Dai Y, McCarty KD, Roberts E, Sinha S, <strong>Li J<\/strong>, Li X, Gad EM, Zhou Z, Shi J, Burgess RA, Hargrove TY, Lepesheva GI, Guengerich FP, Auchus RJ, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41345099\/\" target=\"_blank\" rel=\"noreferrer noopener\">A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1.\u00a0<\/a>Nat Commun.\u00a02025 Dec 4;16(1):10611.\u00a0doi: 10.1038\/s41467-025-66558-2.\u00a0PubMed PMID: 41345099; PubMed Central PMCID: PMC12678803.<\/li>\n\n\n\n<li style=\"font-size:18px\">Sands M, Adams S, Lee J, Li M, Wang M, Walsh T Jr, Leon L, Zablah A, Haerens M, Liu Z,<strong>Li J.<\/strong>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/41058763\/\" target=\"_blank\" rel=\"noreferrer noopener\">The interconnection between androgen receptor and DNA damage response pathways in prostate cancer.\u00a0<\/a>Curr Urol.\u00a02025 Nov;19(6):376-387.\u00a0doi: 10.1097\/CU9.0000000000000300.\u00a0Epub 2025 Aug 18.\u00a0Review.\u00a0PubMed PMID: 41058763; PubMed Central PMCID: PMC12499796.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p style=\"font-size:26px\"><strong>2024<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:18px\">Li M, <strong>Li J.<\/strong>\u00a0Steroids in Cancer: Mechanisms, Therapies, and Challenges in Hormone-Driven Malignancies.\u00a0In:\u00a0Nima R, editor.\u00a0Interdisciplinary Cancer Research [Internet]\u00a010.1007\/16833_2024_294: Springer Nature;\u00a02024.\u00a0Available from: https:\/\/link.springer.com\/10.1007\/16833_2024_294.<\/li>\n<\/ul>\n\n\n\n<p style=\"font-size:26px\"><strong>2023-2009<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:18px\">Cui D, <strong>Li J,<\/strong> Zhu Z, Berk M, Hardaway A, McManus J, Chung YM, Alyamani M, Valle S, Tiwari R, Han B, Goudarzi M, Willard B, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37009898\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation.\u00a0<\/a>J Clin Invest.\u00a02023 Apr 3;133(7).\u00a0doi: 10.1172\/JCI161913.\u00a0PubMed PMID: 37009898; PubMed Central PMCID: PMC10065083.<\/li>\n\n\n\n<li style=\"font-size:18px\">Hardaway AL, Goodarzi M, Berk M, <strong>Li J,<\/strong> Chung YM, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36951302\/\" target=\"_blank\" rel=\"noreferrer noopener\">Response to &#8220;Letter to the Editor From Penning and Deltefsen &#8220;5-hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells&#8221;.\u00a0<\/a>Endocrinology.\u00a02023 Mar 13;164(5).\u00a0doi: 10.1210\/endocr\/bqad053.\u00a0PubMed PMID: 36951302.<\/li>\n\n\n\n<li style=\"font-size:18px\">Hardaway AL, Goudarzi M, Berk M, Chung YM, Zhang R, <strong>Li J,<\/strong> Klein E, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36412122\/\" target=\"_blank\" rel=\"noreferrer noopener\">5-Hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells.\u00a0<\/a>Endocrinology.\u00a02022 Nov 14;164(1).\u00a0doi: 10.1210\/endocr\/bqac191.\u00a0PubMed PMID: 36412122; PubMed Central PMCID: PMC9923800.<\/li>\n\n\n\n<li style=\"font-size:18px\">Baratchian M, Tiwari R, Khalighi S, Chakravarthy A, Yuan W, Berk M, <strong>Li J,<\/strong> Guerinot A, de Bono J, Makarov V, Chan TA, Silverman RH, Stark GR, Varadan V, De Carvalho DD, Chakraborty AA, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35584120\/\" target=\"_blank\" rel=\"noreferrer noopener\">H3K9 methylation drives resistance to androgen receptor-antagonist therapy in prostate cancer.\u00a0<\/a>Proc Natl Acad Sci U S A.\u00a02022 May 24;119(21):e2114324119.\u00a0doi: 10.1073\/pnas.2114324119.\u00a0Epub 2022 May 18.\u00a0PubMed PMID: 35584120; PubMed Central PMCID: PMC9173765.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li J,<\/strong> Berk M, Alyamani M, Sabharwal N, Goins C, Alvarado J, Baratchian M, Zhu Z, Stauffer S, Klein EA, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34039740\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation.\u00a0<\/a>Sci Transl Med.\u00a02021 May 26;13(595).\u00a0doi: 10.1126\/scitranslmed.abe8226.\u00a0PubMed PMID: 34039740; PubMed Central PMCID: PMC8319670.<\/li>\n\n\n\n<li style=\"font-size:18px\">Zhu Z, Chung YM, Sergeeva O, Kepe V, Berk M, <strong>Li J,<\/strong> Ko HK, Li Z, Petro M, DiFilippo FP, Lee Z, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30262668\/\" target=\"_blank\" rel=\"noreferrer noopener\">Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging.\u00a0<\/a>J Biol Chem.\u00a02018 Nov 16;293(46):17829-17837.\u00a0doi: 10.1074\/jbc.RA118.004846.\u00a0Epub 2018 Sep 27.\u00a0PubMed PMID: 30262668; PubMed Central PMCID: PMC6240862.<\/li>\n\n\n\n<li style=\"font-size:18px\">Gao X, Dai C, Huang S, Tang J, Chen G, <strong>Li J,<\/strong> Zhu Z, Zhu X, Zhou S, Gao Y, Hou Z, Fang Z, Xu C, Wang J, Wu D, Sharifi N, Li Z.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30228209\/\" target=\"_blank\" rel=\"noreferrer noopener\">Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression.\u00a0<\/a>Clin Cancer Res.\u00a02019 Feb 15;25(4):1291-1301.\u00a0doi: 10.1158\/1078-0432.CCR-18-2392.\u00a0Epub 2018 Sep 18.\u00a0PubMed PMID: 30228209; PubMed Central PMCID: PMC6377858.<\/li>\n\n\n\n<li style=\"font-size:18px\">Dai C, Chung YM, Kovac E, Zhu Z, <strong>Li J,<\/strong> Magi-Galluzzi C, Stephenson AJ, Klein EA, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28733443\/\" target=\"_blank\" rel=\"noreferrer noopener\">Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues.\u00a0<\/a>Clin Cancer Res.\u00a02017 Oct 15;23(20):6351-6362.\u00a0doi: 10.1158\/1078-0432.CCR-17-1313.\u00a0Epub 2017 Jul 21.\u00a0PubMed PMID: 28733443; PubMed Central PMCID: PMC5641243.<\/li>\n\n\n\n<li style=\"font-size:18px\">Alyamani M, Li Z, Berk M, <strong>Li J,<\/strong> Tang J, Upadhyay S, Auchus RJ, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28648378\/\" target=\"_blank\" rel=\"noreferrer noopener\">Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities.\u00a0<\/a>Cell Chem Biol.\u00a02017 Jul 20;24(7):825-832.e6.\u00a0doi: 10.1016\/j.chembiol.2017.05.020.\u00a0Epub 2017 Jun 22.\u00a0PubMed PMID: 28648378; PubMed Central PMCID: PMC5533090.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li J,<\/strong> Alyamani M, Zhang A, Chang KH, Berk M, Li Z, Zhu Z, Petro M, Magi-Galluzzi C, Taplin ME, Garcia JA, Courtney K, Klein EA, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28191869\/\" target=\"_blank\" rel=\"noreferrer noopener\">Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide-resistant prostate cancer.\u00a0<\/a>Elife.\u00a02017 Feb 13;6.\u00a0doi: 10.7554\/eLife.20183.\u00a0PubMed PMID: 28191869; PubMed Central PMCID: PMC5305204.<\/li>\n\n\n\n<li style=\"font-size:18px\">Li Z, Alyamani M, <strong>Li J,<\/strong> Rogacki K, Abazeed M, Upadhyay SK, Balk SP, Taplin ME, Auchus RJ, Sharifi N.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27225130\/\" target=\"_blank\" rel=\"noreferrer noopener\">Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy.\u00a0<\/a>Nature.\u00a02016 May 26;533(7604):547-51.\u00a0doi: 10.1038\/nature17954.\u00a0PubMed PMID: 27225130; PubMed Central PMCID: PMC5111629.<\/li>\n\n\n\n<li style=\"font-size:18px\">Shu Q, Li W, <strong>Li J,<\/strong> Wang W, Liu C, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25229504\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cross-talk between cAMP and MAPK pathways in HSD11B2 induction by hCG in placental trophoblasts.\u00a0<\/a>PLoS One.\u00a02014;9(9):e107938.\u00a0doi: 10.1371\/journal.pone.0107938.\u00a0eCollection 2014.\u00a0PubMed PMID: 25229504; PubMed Central PMCID: PMC4168233.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wu J, <strong>Li J,<\/strong> Xu MH, Liu D.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24880902\/\" target=\"_blank\" rel=\"noreferrer noopener\">Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole.\u00a0<\/a>Bioorg Med Chem Lett.\u00a02014 Jul 15;24(14):3050-6.\u00a0doi: 10.1016\/j.bmcl.2014.05.028.\u00a0Epub 2014 May 20.\u00a0PubMed PMID: 24880902.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wang WS, Liu C, Li WJ, Zhu P, <strong>Li JN,<\/strong> Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24239159\/\" target=\"_blank\" rel=\"noreferrer noopener\">Involvement of CRH and hCG in the induction of aromatase by cortisol in human placental syncytiotrophoblasts.\u00a0<\/a>Placenta.\u00a02014 Jan;35(1):30-6.\u00a0doi: 10.1016\/j.placenta.2013.10.018.\u00a0Epub 2013 Nov 7.\u00a0PubMed PMID: 24239159.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li J,<\/strong> Wang W, Liu C, Wang W, Li W, Shu Q, Chen ZJ, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23714681\/\" target=\"_blank\" rel=\"noreferrer noopener\">Critical role of histone acetylation by p300 in human placental 11\u03b2-HSD2 expression.\u00a0<\/a>J Clin Endocrinol Metab.\u00a02013 Jul;98(7):E1189-97.\u00a0doi: 10.1210\/jc.2012-4291.\u00a0Epub 2013 May 28.\u00a0PubMed PMID: 23714681.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wu J, Zhang D, Chen L, <strong>Li J,<\/strong> Wang J, Ning C, Yu N, Zhao F, Chen D, Chen X, Chen K, Jiang H, Liu H, Liu D.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23316803\/\" target=\"_blank\" rel=\"noreferrer noopener\">Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.\u00a0<\/a>J Med Chem.\u00a02013 Feb 14;56(3):761-80.\u00a0doi: 10.1021\/jm301032j.\u00a0Epub 2013 Jan 28.\u00a0PubMed PMID: 23316803.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wang W, Guo C, Li W, <strong>Li J,<\/strong> Wang W, Myatt L, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23125313\/\" target=\"_blank\" rel=\"noreferrer noopener\">Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts.\u00a0<\/a>Endocrinology.\u00a02012 Dec;153(12):5993-6002.\u00a0doi: 10.1210\/en.2012-1531.\u00a0Epub 2012 Nov 2.\u00a0PubMed PMID: 23125313; PubMed Central PMCID: PMC3512073.<\/li>\n\n\n\n<li style=\"font-size:18px\">Wang W, <strong>Li J,<\/strong> Ge Y, Li W, Shu Q, Guan H, Yang K, Myatt L, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22315456\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP\/Sp1 pathway.\u00a0<\/a>Endocrinology.\u00a02012 Apr;153(4):2012-22.\u00a0doi: 10.1210\/en.2011-1626.\u00a0Epub 2012 Feb 7.\u00a0PubMed PMID: 22315456.<\/li>\n\n\n\n<li style=\"font-size:18px\">Ge YC, <strong>Li JN,<\/strong> Ni XT, Guo CM, Wang WS, Duan T, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21562093\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts.\u00a0<\/a>Reproduction.\u00a02011 Aug;142(2):369-75.\u00a0doi: 10.1530\/REP-11-0053.\u00a0Epub 2011 May 11.\u00a0PubMed PMID: 21562093.<\/li>\n\n\n\n<li style=\"font-size:18px\"><strong>Li JN,<\/strong> Ge YC, Yang Z, Guo CM, Duan T, Myatt L, Guan H, Yang K, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21411560\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts.\u00a0<\/a>J Clin Endocrinol Metab.\u00a02011 Jun;96(6):E899-907.\u00a0doi: 10.1210\/jc.2010-2852.\u00a0Epub 2011 Mar 16.\u00a0PubMed PMID: 21411560.select<\/li>\n\n\n\n<li style=\"font-size:18px\">Guo C, <strong>Li J,<\/strong> Myatt L, Zhu X, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20203101\/\" target=\"_blank\" rel=\"noreferrer noopener\">Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts.\u00a0<\/a>Mol Endocrinol.\u00a02010 May;24(5):1052-61.\u00a0doi: 10.1210\/me.2009-0488.\u00a0Epub 2010 Mar 4.\u00a0PubMed PMID: 20203101; PubMed Central PMCID: PMC5417499.select<\/li>\n\n\n\n<li style=\"font-size:18px\">Ni XT, Duan T, Yang Z, Guo CM, <strong>Li JN,<\/strong> Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19880179\/\" target=\"_blank\" rel=\"noreferrer noopener\">Role of human chorionic gonadotropin in maintaining 11beta-hydroxysteroid dehydrogenase type 2 expression in human placental syncytiotrophoblasts.\u00a0<\/a>Placenta.\u00a02009 Dec;30(12):1023-8.\u00a0doi: 10.1016\/j.placenta.2009.10.005.\u00a0Epub 2009 Oct 31.\u00a0PubMed PMID: 19880179.select<\/li>\n\n\n\n<li style=\"font-size:18px\">Zhu XO, Yang Z, Guo CM, Ni XT, <strong>Li JN,<\/strong> Ge YC, Myatt L, Sun K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19797430\/\" target=\"_blank\" rel=\"noreferrer noopener\">Paradoxical stimulation of cyclooxygenase-2 expression by glucocorticoids via a cyclic AMP response element in human amnion fibroblasts.\u00a0<\/a>Mol Endocrinol.\u00a02009 Nov;23(11):1839-49.\u00a0doi: 10.1210\/me.2009-0201.\u00a0Epub 2009 Oct 1.\u00a0PubMed PMID: 19797430; PubMed Central PMCID: PMC5419155.<\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>2025 2024 2023-2009<\/p>\n","protected":false},"author":5239,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"[]"},"class_list":["post-39","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/users\/5239"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":2,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":42,"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/pages\/39\/revisions\/42"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/lilab\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}