{"id":18,"date":"2019-04-08T14:45:06","date_gmt":"2019-04-08T18:45:06","guid":{"rendered":"http:\/\/sites.nd.edu\/melanderlab\/?page_id=18"},"modified":"2026-10-02T12:13:10","modified_gmt":"2026-10-02T16:13:10","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/melanderlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n


192. Gondil, V. S., Stefaniak, M. A., Melander, C. and Dunman, P. M. Penicillin Binding Protein 4: An emerging Staphylococcus aureus <\/em>therapeutic target. Frontiers in Cellular and Infection Microbiology<\/em>. Accepted.<\/em>
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191. Zeiler, M. J., Hance, E. M., Melander, R. J., Oliver, A. G., Quave, C. L. and Melander, C. Investigations into the Role of the Decalin Ring System on the Activity of Diterpene-Based \u03b2-Lactam Adjuvants. Synthesis<\/em>. 2026<\/strong>. doi.org\/10.1055\/a-2952-8747<\/a><\/p>\n\n\n\n

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190. Nemeth, A. M., Stefaniak, M. A., Crotteau, A. N., Doi, Y., Ernst, R. K., Melander, R. J. and Melander, C. Expanding the Utility of Colistin Adjuvants To Encompass Next-Generation Polymyxins against Polymyxin-Resistant Acinetobacter baumannii<\/em> and Klebsiella pneumoniae<\/em>. ACS Infectious Dis<\/em>eases. 2026<\/strong>. doi.org\/10.1021\/acsinfecdis.6c00742<\/a><\/p>\n\n\n\n

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189. Stefaniak, M. A., Gondil, V. S., Yang, J., Adilijiang, W., Oliver, A. G., Nemeth, A. M., Melander, R. J., Chang, M., Dunman, P. M. and Melander, C. Discovery of a Novel Benzothiophene Inhibitor of Penicillin-Binding Protein 2 with Potent Gram-positive Activity. Antibiotics. <\/em>2026<\/strong>, 15(9), 826. doi.org\/10.3390\/antibiotics15090826<\/a><\/p>\n\n\n\n

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188. Sorge, A., Stiles, A., Nemeth, A. M., O\u2019Keefe, I, Melander, R. J., Doi, Y., Ernst, R., K. and Melander, C. Sorafenib Analogues Exhibit Dual Colistin-Potentiating and Anti-MRSA Activity. RSC Medicinal Chemistry. RSC Med. Chem.<\/em> 2026<\/strong>. doi.org\/10.1039\/D6MD00388E<\/a><\/p>\n\n\n\n

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187. Shen, Y., Nemeth, A. M., Melander, R. J., Melander, C. and Chang, W-C. High-Yield Production of Metacycloprodigiosin from Streptomyces spectabilis <\/em>and Restoration of Colistin Susceptibility in Colistin-Resistant Gram-Negative Pathogens. Organic and Biomolecular Chemistry.<\/em> 2026<\/strong>, 24(29): 5971\u20135982. doi.org\/10.1039\/d6ob00770h<\/a><\/p>\n\n\n\n

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186. Sorge, A., Bennett, A. N., Gregory, S. E., Cole, A. L., Woolard, K. J., Nemeth, A. M., Crow, A. H., Melander, R. J., Gunn, J. S. and Melander, C. Structure-Activity Relationship Analysis and hERG Liability Assessment of Second-Generation Anti-Biofilm Compounds Active Against Salmonella. ChemMedChem, <\/em>2026<\/strong>, <\/em>21, e70363.  <\/em>doi.org\/10.1002\/cmdc.70363<\/a><\/p>\n\n\n\n

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185. Cowart, L. J., Nemeth, A. M., Jania, L. A., Overly, M., Ellis, C. F., Koller, B. H., Melander, R. J., Doi, Y., Ernst, R. K. and Melander, C. IMD-0354 Optimization Generates Potent Colistin Adjuvants with In vivo Activity and Reduced Eukaryotic Toxicity. European Journal of Medicinal Chemistry. <\/em>2026<\/strong>, 316, 119028. doi.org\/10.1016\/j.ejmech.2026.119028<\/a><\/p>\n\n\n\n

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184. Kittleson, B., Woo, S., Marquez, L., Zeiler, M., Daher, I., Melander, C. and Quave, C. Growth-Inhibitory Activity of a Clerodane Diterpene from Callicarpa americana<\/em> Leaf Extracts and its Derivatives Against Cutibacterium acnes<\/em>. ACS Infectious Diseases. <\/em>2026<\/strong>, 12, 5, 1662\u20131668. doi.org\/10.1021\/acsinfecdis.5c01116<\/a><\/p>\n\n\n\n

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183. Stefaniak, M. A., Gondil, V. S., Gillis, E. P., Nemeth, A. M., Oliver, A. G., Melander, R. J., Dunman, P. M., and Melander, C. Exploration of a Benzothiophene Scaffold for use as Adjuvants with \u03b2-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus<\/em>. RSC Medicinal Chemistry<\/em>. 2026<\/strong>,17, 2444-2454. doi.org\/10.1039\/D5MD01109D<\/a><\/p>\n\n\n\n

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182. Kinkead, J., Hondros, A. D., Figg, A., M., Young, M. M., Thompson, R. J., Melander, C. and Cavanagh, J. Recombinant Cytosolic Truncations of Histidine Kinases Retain Function. <\/strong>Microorganisms. <\/em>2026<\/strong>, 14(2), 510. doi.org\/10.3390\/microorganisms14020510<\/a><\/p>\n\n\n\n

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181. Cole, A. L., Woolard, K. J., Sorge, A., Melander, C. and Gunn, J. S. A Mouse Model for Studying Chronic Salmonella <\/em>Typhi Infection and Anti-Biofilm Interventions mBio<\/em>. 2026<\/strong>. 17:e03476-25. doi.org\/10.1128\/mbio.03476-25<\/a><\/p>\n\n\n\n

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180. Jaimes, F. E., Hondros, A. D., Kinkead, J., Milton, M. E., Thopson, R. J., Figg, A. M., Melander, C. and Cavanagh, J. Mutations in PmrA Drug Resistant Acinetobacter baumannii<\/em> Affect Sensor Kinase-Response Regulator Interaction and Phosphotransfer. Microorganisms<\/em>. 2025<\/strong>, 13(11), 2600. doi.org\/10.3390\/microorganisms13112600<\/a><\/p>\n\n\n\n

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179. Mattingly, A. E., Doi, Y. and Melander, C. Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa<\/em> clinical isolates from the cystic fibrosis lung. Microbiology Resource Announcements. <\/em>2025<\/strong>, 0:e00558-25. doi.org\/10.1128\/mra.00558-25<\/a><\/p>\n\n\n\n

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178. Lin, B., Woo, S., Philbrick, A., Bacsa, J., Laskey, E., Mehra, N., Gondil, V. S., Mei, J. A., Jones, G., Pavelka, M. S., Dziejman, M., Shutter, D. A., Melander, C., Perritt, A. M., Jakober, R., Shen, Y., Chang, W.-C., Quave, C. L., Dunman, P. M. and Luedemann, G. Testing the Luedemann Hypothesis: The Discovery of Novel Antimicrobials from Slow-Growing Microbes from Nutrient Limited Environments. mSphere, <\/em>2025<\/strong>, 0:e00367-25. <\/em>doi.org\/10.1128\/msphere.00367-25<\/a><\/p>\n\n\n\n

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177. Bennett, A. N., Maziarz, J. F., Laipply, B., Cole, A. L., Woolard, K. J., Sorge, A., Zeiler, M. J., Melander, R. J., Melander, C. and Gunn, J. S. Mechanisms of Antibiofilm Compounds JG-1 and M4 Across Multiple Species: Alterations of Protein Interactions Essential to Biofilm Formation. Frontiers in Cellular and Infection Microbiology, <\/em>2025<\/strong>, 15, 1631575. doi.org\/10.3389\/fcimb.2025.1631575<\/a><\/p>\n\n\n\n

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176. Crotteau, A. N., Nemeth, A. M., Melander, R. J. and Melander, C. 2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii<\/em>. ACS Medicinal Chemistry Letters<\/em>. 2025<\/strong>, 16, 8, 1562\u20131568. doi.org\/10.1021\/acsmedchemlett.5c00201<\/a><\/p>\n\n\n\n

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175. Mattingly, A. E., Li, H., Melander, R. J. and Melander, C. Validation of a Cystic Fibrosis Co-culture Model for the Identification of Dual Acting Compounds with Antibiotic and Antibiotic Adjuvant Properties. ACS Infectious Disease<\/em>s. 2025<\/strong>, 11, 6, 1686\u20131696. doi.org\/10.1021\/acsinfecdis.5c00226<\/a><\/p>\n\n\n\n

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174. Butman, H. S., Stefaniak, M. A., Walsh, D. J., Gondil, V. S., Young, M., Crow, A. H., Nemeth, A. M., Melander, R. J., Dunman, P. M., and MelanderC. Phenyl urea based adjuvants for \u03b2-lactam antibiotics against methicillin resistant Staphylococcus aureus<\/em>. Bioorganic and Medicinal Chemistry Letters<\/em>. 2025<\/strong>, 21, 130164. doi.org\/10.1016\/j.bmcl.2025.130164<\/a><\/p>\n\n\n\n

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173. Hondros, A., Young, M., Jaimes, F., Kinkead, J., Thompson, R., Melander, C., and Cavanagh, J. Two-component system sensor kinase inhibitors target the ATP-lid of PmrB to disrupt colistin resistance in Acinetobacter baumannii. Biochemistry<\/em>. 2025<\/strong>, 64, 6, 1317\u20131327. doi.org\/10.1021\/acs.biochem.4c00789<\/a><\/p>\n\n\n\n

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172. Koller, B. H., Jania, L. A., Li , H., Barker, W. T., Melander, R. J., and Melander, C. Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination. Antimicrobial Agents and Chemotherapy<\/em>. 2024<\/strong>, 68:e00671-24. doi.org\/10.1128\/aac.00671-24<\/a><\/p>\n\n\n\n

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171. Gondil, V. S., Butman, H. S., Young, M., Walsh, D. J., Narkhede, Y., Zeiler, M. J., Crow, A. H., Carpenter, M. E., Mardikar, A., Melander, R. J., Wiest, O., Dunman, P.M., and Melander, C. Development of Phenyl-urea Based Small Molecules that Target Penicillin Binding Protein 4. Chemical Biology and Drug Design. <\/em>2024<\/strong>, 103 (6) e14569. <\/em>doi.org\/10.1111\/cbdd.14569<\/a><\/p>\n\n\n\n

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170. Nemeth, A. N., Young, M. M., Melander, R. J., Smith, R. D., Ernst, R. K., and Melander, C. <\/sup>Identification of a 2-aminobenzimidazole scaffold that potentiates gram-positive selective antibiotics against gram-negative bacteria. ChemBioChem. <\/em>2024<\/strong>, 25, e2024001. <\/em>doi.org\/10.1002\/cbic.202400127<\/a><\/p>\n\n\n\n

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169. Li, H., Nemeth, A. M., Melander, R. J., and Melander, C. Synthesis, Stereochemical Resolution, and Analog Synthesis of Variabiline, an Aporphine Alkaloid that Sensitizes Acinetobacter baumannii<\/em> and Klebsiella pneumoniae <\/em>to Colistin. ACS Infectious Diseases.<\/em> 2024<\/strong>, 10(4), 1339\u20131350. doi.org\/10.1021\/acsinfecdis.4c00026<\/a><\/p>\n\n\n\n

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168. Crotteau, A. N., Hubble, V. B., Marrujo, S. A., Mattingly, A. E., Melander, R. J., and Melander, C. Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants. Antibiotics. <\/em>2023<\/strong>, 12(11), 1563. <\/em>doi.org\/10.3390\/antibiotics12111563<\/a><\/p>\n\n\n\n

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<\/a>167. Bennett, A. N., Woolard, K. J., Sorge, A., Melander, C., and Gunn, J. S. Spectrum of activity of Salmonella <\/em>anti-biofilm compounds: Evaluation of activity against biofilm-forming ESKAPE pathogens. Biofilm. <\/em>2023<\/strong>, 6, 100158. doi.org\/10.1016\/j.bioflm.2023.100158 <\/a><\/p>\n\n\n\n

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166. Harper, E. I., Siroky, M. D.,  Hilliard, T. S., Dominique, G. M., Hammond, C., Liu, Y., Yang, J., Hubble, V. B., Walsh, D. J., Melander, R. J., Melander, C., Blagg, B. S. J., and Stack, M. S. Advanced glycation end products as a potential target for restructuring the ovarian cancer microenvironment: a pilot study. International Journal of Molecular Sciences. <\/em>2023<\/strong>, 24(12), 9804 <\/em>doi.org\/10.3390\/ijms24129804<\/a><\/p>\n\n\n\n

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165. Jenul, C., Keim, K., Jens, J., Zeiler, M. J., Schilcher, K., Schurr, M., Melander, C., Phelan, V. V., and Horswill, A. R. Pyochelin Biotransformation Shapes Bacterial Competition. Cell Reports<\/em>, 2023<\/strong>, 42 (6), 112540. doi.org\/10.1016\/j.celrep.2023.112540<\/a><\/p>\n\n\n\n

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164. Liu, C., Zhang, H., Peng, X., Blackledge, M. S., Furlani, R. E., Li, H., Su, Z., Melander, R. J., Melander, C., Michalek, S., and Wu H. Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. mBio<\/em>. 2023<\/strong>, 14 (3), doi\/10.1128\/mbio.00137-23<\/a><\/p>\n\n\n\n

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163. Weig, A. W., O\u2019Conner, P. M., Kwiecinski, J. M., Marciano, O. M., Nunag, A., Gutierrez, A. T., Melander, R. J., Horswill, A. R., and Melander, C. A Structure Activity Relationship Study of 3,4\u2019-Dimethoxyflavone for ArlRS Inhibition in Staphylococcus aureus<\/em>. Organic and Biomolecular Chemistry. <\/em>2023<\/strong>, 21, 3373-3380. doi.org\/10.1039\/<\/a>D3OB00123G<\/a> <\/p>\n\n\n\n

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162. Marrujo, S. A., Hubble, V. B., Yang, J., Wang, M., Nemeth, A. M., Barlock, S. L., Juarez, D., Smith, R. D., Melander, R. J., Ernst, R. K., Chang, M., and Melander, C. Dimeric 2-Aminoimidazoles are Highly Active Adjuvants for Gram-positive Selective Antibiotics against Acinetobacter baumannii. European Journal of Medicinal Chemistry. <\/em>2023<\/strong>, 253, 115329. <\/em>doi.org\/10.1016\/j.ejmech.2023.115329<\/a><\/p>\n\n\n\n

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161. Onyedibe, K., Nemeth, A. M., Dayal, N., Smith, R., Ernst, R. K., Melander, R. J., Melander, C., and Sintim, H. Re-sensitization of Multidrug Resistant and Colistin Resistant Gram-negative Bacteria to Colistin by Povarov\/Doebner Derived Compounds. ACS Infectious Diseases, <\/em>2023<\/strong>, 9, (2) 283\u2013295. doi.org\/10.1021\/acsinfecdis.2c00417<\/a><\/p>\n\n\n\n

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160. Li, H., Mattingly, A. E., Smith, R. D., Melander, R. J., Ernst, <\/sup>R. K., and Melander, C. 6-Bromoindirubin-3\u2019-oxime Derivatives are Highly <\/a>Active Colistin Adjuvants against Klebsiella pneumoniae<\/em>. RSC Medicinal Chemistry<\/em>, 2023<\/strong>,14, 247-252. doi.org\/10.1039\/D2MD00370H<\/a><\/p>\n\n\n\n

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159. Melander, R. J., Mattingly, A. E., Nemeth, A. M., and Melander, C. Overcoming Intrinsic Resistance in Gram-negative Bacteria using Small Molecule Adjuvants. (Invited Digest) Bioorganic and Medicinal Chemistry Letters, <\/em>2023<\/strong>, 80, 129113. doi.org\/10.1016\/j.bmcl.2022.129113<\/a> <\/p>\n\n\n\n

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158. Zeczycki, T. N., Milton, M. E., Jung, D., Thompson, R. J., Jaimes, F. E., Hondros, A. D., Palethorpe, S., Melander, C., and Cavanagh, J. 2-Aminoimidazole Analogs Target PhoP Altering DNA Binding Activity and Affect Outer Membrane Stability in Gram-Negative Bacteria. Biochemistry<\/em>, 2022<\/strong>, 61 (24) 2948\u20132960. doi.org\/10.1021\/acs.biochem.2c00560<\/a><\/a><\/p>\n\n\n\n

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157. Young, M., Walsh, D. J., Masters, E., Singh Gondil, V., Laskey, E., Klaczko, M., Awad, H., McGrath, J., Schwarz, E. M., Melander, C. and Dunman, P. M. Identification of Staphylococcus aureus<\/em> Penicillin Binding Protein 4 (PBP4) inhibitors. Antibiotics.<\/em><\/em> 2022<\/strong>, 11(10), 1351. doi.org\/10.3390\/<\/a>antibiotics11101351<\/a><\/p>\n\n\n\n

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156. Siwawannapong, K., Nemeth, A. M., Melander, R. J., Rong, J., Davis, J. R., Taniguchi, M., Carpenter, M. E., Lindsey, J. S., and Melander, C. Simple Dipyrrin Analogues of Prodigiosin for use as Colistin Adjuvants, ChemMedChem<\/em>. 2022<\/strong>, 17(6) e202200286doi.org\/10.1002\/cmdc.202200286<\/a><\/p>\n\n\n\n

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155. Hoang, K.V., Woolard, K., Yang, C., Melander, C., and Gunn, J.S. Identification of a Host-Targeted Molecule to Control Typhoid Fever. Microbiology Spectrum. Antimicrobial Chemotherapy<\/em>. 2022<\/strong>, 10(3) e00619-22 doi.org\/10.1128\/spectrum.00619-<\/a>22<\/a><\/p>\n\n\n\n

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154. Belardinelli, J.M, Li, W., Martin, K.H., Zeiler, M.J., Lian, E., Avanzi, C., Wiersma, C.J., Nguyen, T.V., Angala, B., de Moura, V.C.N., Jones, V., Borlee, B.R., Melander, C., and Jackson, M. 2-Aminoimidazoles Inhibit Mycobacterium abscessus<\/em> Biofilms in a Zinc-Dependent Manner. Int. J. Mol. Sci.<\/em> 2022<\/strong>, 23(6) 2950. doi.org\/10.3390\/ijms23062950<\/a><\/p>\n\n\n\n

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153. Zeiler, M. J., Connors, G. M., Durling, G. M., Oliver, A. G., Marquez, M., Melander, R. J., Quave, C. L., and Melander, C. Synthesis, Stereochemical Confirmation, and Derivatization of 12(S<\/em>),16e-Dihydroxycleroda-3,13-dien-15,16-olide, a Clerodane Diterpene That Sensitizes Methicillin-Resistant Staphylococcus aureus<\/em> to \u03b2-Lactam Antibiotics. Angewandte Chemie.<\/em> 2022<\/strong>, 61 (17) e202117458 doi.org\/10.1002\/ange.202117458<\/a><\/p>\n\n\n\n

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152. Woolard, K., Sandala, J. L., <\/span>Melander, R. J., Gunn, J. S., and Melander, C. Development Of Small Molecules That Work Cooperatively With Ciprofloxacin To Clear Salmonella Biofilms In A Chronic Gallbladder Carriage Model. European Journal of Medicinal Chemistry<\/em>. 2022<\/strong>, 232, 114203. doi.org\/10.1016\/j.ejmech.2022.114203<\/a><\/p>\n\n\n\n

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151. Bailey, J., Gallagher, L. A., Barker, W. T., Hubble, V. B., Gasper, J., Melander, C., and Manoil<\/span>, C. Genetic Dissection of Antibiotic Adjuvant Activity. mBio. <\/em>2022<\/strong>, 13 (1)  e03084-21. doi.org\/10.1128\/mbio.03084-21<\/a><\/p>\n\n\n\n

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150. Melander, R. J., Mattingly, A. E., and Melander, C. Phenotypic Screening of Compound Libraries as a Platform for the Identification of Antibiotic Adjuvants \u2013 Identification of Colistin Adjuvants from a Natural Product Library. Methods in Enzymology. <\/em>2022<\/strong>, 665, 53-176. doi.org\/10.1016\/bs.mie.2021.11.005<\/a><\/p>\n\n\n\n

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149. Li, H., Mattingly, A. E., Jania, L. A., Smith, R., Melander, R. J., Ernst, R. K., Koller, B. H., and Melander, C. Benzimidazole Isosteres of Salicylanilides are Highly Active Colistin Adjuvants. ACS Infectious Diseases. <\/em>2021<\/span><\/strong>, <\/span><\/em>7<\/span> <\/span><\/em>(12)<\/span> <\/span>3303\u20133313. <\/span>doi.org\/10.1021\/acsinfecdis.1c00463<\/a><\/p>\n\n\n\n

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148. Borrel, A., Melander, C., and Fourches, D. Chemoinformatics Analysis of
Fluoroquinolones and Their Inhibition Potency Against Four Pathogens. Molecular Informatics. <\/em>2021<\/strong>, 40 (5) 2000215. doi.org\/10.1002\/minf.202000215<\/a><\/p>\n\n\n\n

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147. Weig, A. W., Barlock, S. L., O’Connor, P. M.,  Marciano, O. M., Melander, R. J., and Melander, C. A Scaffold Hopping Strategy to Generate New Aryl-2-Amino Pyrimidine MRSA Biofilm Inhibitors. RSC Medicinal Chemistry. <\/span><\/span><\/em>2021<\/strong>, <\/span><\/span>12<\/span><\/span>, 293-296.<\/span><\/span> doi.org\/10.1039\/D0MD00<\/span><\/span>238K<\/span><\/span><\/a><\/p>\n\n\n\n

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146. Sandala, J. L, Eichar, B. W., Kuo, L. G., Hahn, M. M., Basak, A. K.,  Huggins, W. M., Woolard, K., Melander, C., and  Gunn, J. S. A Dual-therapy Approach for the Treatment of Biofilm-mediated Salmonella <\/em>Gallbladder Carriage. PLOS Pathogens, <\/em>2020<\/strong>, 16 (12): e1009192. doi.org\/10.1371\/journal.ppat.1009192<\/a><\/p>\n\n\n\n

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145. Barker, W. T., Jania, L. A., Melander, R. J.,  Koller, B. H., and Melander, C. Eukaryotic Phosphatase Inhibitors Enhance Colistin Efficacy in Gram-negative Bacteria. Chemical Biology & Drug Design. <\/em>2020<\/strong>, 96 (5) 1180-1186. doi.org\/10.1111\/cbdd.13735<\/a><\/p>\n\n\n\n

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144. Melander, R. J., Basak, A. K., and Melander, C. Natural Products as Inspiration for the Development of Bacterial Antibiofilm Agents. Natural Product Reports. <\/em>2020<\/strong>, 37, 1454 – 1477. doi.org\/10.1039\/D0NP00022A<\/a><\/p>\n\n\n\n

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143. Mattingly, A. E.,  Cox, K. E., Smith, R., Melander, R. J., Ernst,  R. K., and Melander, C. Screening an Established Natural Product Library Identifies Secondary Metabolites that Potentiate Conventional Antibiotics. ACS Infectious Diseases. <\/em>2020<\/span><\/strong>, <\/span><\/em>6<\/span> (<\/span>10)<\/span> <\/span><\/em>2629\u20132640.<\/span> doi.org\/10.1021\/acsinfecdis.0c00259<\/a><\/p>\n\n\n\n

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142. Rasapalli, S., <\/span><\/span>Murphy, Z. F., <\/span><\/span>Sammeta, V., <\/span><\/span>Golen, J. A., <\/span><\/span>Weig, A. W., <\/span><\/span>Melander, R. J., <\/span><\/span>Melander, C., <\/span><\/span>Macha, P., <\/span><\/span>Vasudev, M., C. <\/span><\/span>Synthesis and Biofilm Inhibition Studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H<\/em>)-ones. <\/span>Bioorganic & Medicinal Chemistry Letters. <\/span><\/em>2020<\/span><\/strong>, <\/span><\/em>30 (23)<\/span> <\/span><\/em>127550.<\/span> doi.org\/10.1016\/j.bmcl.2020.127550<\/a><\/p>\n\n\n\n

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141. Hubble, V. B, Bartholomew, K., Weig, A. W., Brackett, S. M., Barlock, S. L., Mattingly, A. E., Nemeth, A. M., Melander, R. J., and Melander, C. Augmenting the Activity of Macrolide Adjuvants Against Acinetobacter baumannii.<\/em> ACS Medicinal Chemistry Letters, <\/i><\/span><\/em>2020<\/span><\/strong>, 11 (<\/span>9)<\/span> 1723\u2013173<\/span>1. <\/span>doi.org\/10.1021\/acsmedchemlett.0c00276<\/a><\/p>\n\n\n\n

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140. Zeiler, M. J., Melander, R. J.,  and Melander, C. Second Generation Meridianin Analogs Inhibit the Formation of Mycobacterium smegmatis Biofilms<\/em> and Sensitize Polymyxin-Resistant Gram-Negative Bacteria to Colistin. ChemMedChem. <\/em>2020<\/strong> 15<\/span>, (17) <\/span>1672-167 doi.org\/10.1002\/cmdc.202000438<\/a><\/p>\n\n\n\n

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139. Dettweiler, M., Melander, R. J., Porras, G., Risener, C., Marquez, L., Samarakoon, T., Melander, C., and Quave, C. L. A Clerodane Diterpene from Callicarpa americana<\/em> Resensitizes Methicillin-Resistant Staphylococcus aureus<\/em> to \u00df-Lactam Antibiotics. ACS Infectious Diseases. <\/em>2020<\/span><\/strong>, <\/span><\/em>6 (<\/span>7) <\/span>1667\u20131673 <\/span>doi.org\/10.1021\/acsinfecdis.0c00307<\/a><\/p>\n\n\n\n

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138. Brackett, S. M.,  Cox, K. E.,  Barlock, S. L.,  Huggins, W. M.,  Ackart, D. F.,  Bassaraba, R. J.,  Melander, R. J., and Melander, C. Meridianin D Analogues Possess Antibiofilm Activity Against Mycobacterium smegmatis. RSC Medicinal Chemistry. <\/em>2020<\/strong>, 11, 92-97 doi.org\/10.1039\/C9MD00466A<\/a><\/p>\n\n\n\n

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137. Nemeth, A. M., Basak, A. K., Weig, A. W., Marrujo, S. A., Barker, W. T., Jania, L. A., Hendricks, T. A., Sullivan, A. E., O\u2019Connor, P. M., Melander, R. J., Koller, B. H., and Melander. C. Structure Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants. ChemMedChem. <\/em>2020<\/strong>, 15 (2) 210-218 doi.org\/10.1002\/cmdc.201900560<\/a><\/p>\n\n\n\n

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136. Yan, A., Huang, M., Melander, C., Kjellerup, B. Dispersal and Inhibition of Biofilms Associated with Infections.  Journal of Applied Microbiology. <\/em>2020<\/strong>, 128 (5) 1279-1288. doi.org\/10.1111\/jam.14491<\/a><\/p>\n\n\n\n

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135. Melander R.J., Melander C. Strategies for the Eradication of Biofilm-Based Bacterial Infections. Antibacterial Drug Discovery to Combat MDR. (Springer)<\/em> 2019<\/strong>, 499-526 doi.org\/10.1007\/978-981-13-9871-1_22<\/a><\/p>\n\n\n\n

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134. Barker, W. T., Nemeth, A. M., Brackett, S. M., Basak, A. K., Chandler, C. E., Jania, L. A., Zuercher, W. J., Melander, R. J., Koller, B. H., Ernst, R. K. and Melander, C. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-negative Bacteria. ACS Infectious Diseases, <\/em>2019<\/span><\/strong>, <\/span><\/em>5<\/span>, <\/span><\/em>(10), <\/span>1764-1771 <\/span>doi.org\/10.1021\/acsinfecdis.9b00212<\/a><\/p>\n\n\n\n

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133. Cox, K.E., and Melander, C. Antibiofilm Activity of Quinazoline Derivatives against Mycobacterium smegmatis. MedChemComm, <\/em>2019, <\/strong>10, 1177-1179 doi.org\/10.1039\/C9MD00156E<\/a><\/p>\n\n\n\n

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132. Martin, S.E., Melander, R.J., Brackett, C.M., Scott, A.J., Chandler, C.E., Nguyen, C.M., Minrovic, B.M., Harrill, S.E., Ernst. R.K., Manoil, C., and Melander, C. Small Molecule Potentiation of Gram-positive Selective Antibiotics Against Acinetobacter baumannii<\/em>. ACS Infectious Diseases, <\/em>2019<\/strong>, 5, (7), 1223-1230 doi.org\/10.1021\/acsinfecdis.9b00067<\/a><\/p>\n\n\n\n

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131. Minrovic, B.M., Hubble, V.B., Barker, W.T., Jania, L.A., Melander, R.J., Koller, B.H., and Melander, C. Second Generation Tryptamine Derivatives Potently Sensitize Colistin-Resistant Bacteria to Colistin. ACS Medicinal Chemistry Letters, <\/em>2019<\/strong>, <\/em>10 (5), 828-833. doi.org\/10.1021\/acsmedchemlett.9b00135<\/a><\/p>\n\n\n\n

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130. Barker, W.T., Chandler, C.E., Melander, R.J., Ernst, R.K., and Melander, C. Tryptamine Derivatives Disarm Colistin Resistance in Polymyxin-Resistant Gram-negative Bacteria. Bioorganic and Medicinal Chemistry, <\/em>2019<\/strong>, 27 (9), 1776-1788. doi.org\/10.1016\/j.bmc.2019.03.019<\/a><\/p>\n\n\n\n

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129. Nguyen, T.V., Minrovic, B.M., Melander, R.J., and Melander, C. Identification of Anti\u2010Mycobacterial Biofilm Agents Based on the 2\u2010Aminoimidazole Scaffold, ChemMedChem, <\/em>2019<\/strong>, 14 (9) 927-937. doi.org\/10.1002\/cmdc.201900033<\/a><\/p>\n\n\n\n

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128. Nguyen, T.V., Peszko, M.T., Melander, R.J., and Melander, C. Using 2-Aminobenzimidazole Derivatives to Inhibit Mycobacterium smegmatis <\/em>Biofilm Formation, Med. Chem. Commun.<\/i>, 2019<\/strong>,10, 456-459. doi.org\/10.1039\/C9MD00025A<\/a><\/p>\n\n\n\n

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127. Hubble, V.B., Hubbard, B., Minrovic, B.M., Melander, R.J., and Melander, C. Using Small Molecule Adjuvants to Repurpose Azithromycin for Use Against Pseudomonas aeruginosa<\/em>. ACS Infectious Diseases, <\/em>2019<\/strong>, <\/em>5 (1), 141-151. doi.org\/10.1021\/acsinfecdis.8b00288<\/a><\/p>\n\n\n\n

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126. Jeon, A.B., Ackart, D.F., Li, W., Jackson, M., Melander, R.J., Melander, C., Abramovitch, R.B., Chicco, A.J., Basaraba, R.J., Obregon-Henao, A. 2-Aminoimidazoles Collapse Mycobacterial Proton Motive Force and Block the Electron Transport Chain, Scientific Reports<\/em>, 2019<\/strong>, 9 <\/em>(1), <\/em>1513. <\/em>doi.org\/10.1038\/s41598-018-38064-7<\/a><\/p>\n\n\n\n

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125. Huggins, W.M., Nguyen, T.V., Hahn, N.A., Baker, J.T., Kuo, L.G., Kaur, D., Melander, R.J., Gunn, J.S., and Melander, C. 2-Aminobenzimidazoles as Antibiofilm Agents Against Salmonella eterica <\/em>Serovar Typhimurium. MedChemComm, <\/em>2018<\/strong>, 9 <\/em>(9), <\/em>1547-1522. doi.org\/10.1039\/c8md00298c<\/a><\/p>\n\n\n\n

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124. Minrovic, B.M., Jung, D., Melander, R.J., and Melander, C. A New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumanii<\/em>. ACS Infectious Diseases, <\/em>2018<\/strong>, 4 <\/em>(9), <\/em>1368-1376. <\/em>doi.org\/10.1021\/acsinfecdis.8b00103<\/a><\/p>\n\n\n\n

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123. Huggins, W.M., Barker, W.T., Baker, J.T., Hahn, N., Melander, R.J., and Melander, C. Meridianin D Analogues Display Antibiofilm Activity Against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria. ACS Medicinal Chemistry Letters, <\/em>2018<\/strong>, 9 <\/em>(7), <\/em>702-707 doi.org\/10.1021\/acsmedchemlett.8b00161<\/a><\/p>\n\n\n\n

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122. Martin, S.E., Nguyen, C.M., Basaraba, R.J., and Melander, C. Analogue Synthesis Reveals Decoupling of Antibiofilm and \u00df-Lactam Potentiation Activities of a Lead 2-Aminoimidazole Adjuvant Against Mycobacterium smegmatis. Chemical Biology & Drug Design, <\/em>2018<\/strong>, 92 <\/em>(3), <\/em>1403-1408. <\/em>doi.org\/10.1111\/cbdd.13208<\/a><\/p>\n\n\n\n

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121. Milton, M.E., Minrovic, B.M., Harris, D., Kang, B., Jung, D., Lewis, C.P., Thompson, R.J., Melander, R. J., Zeng, D., Melander, C., and Cavanagh, J. Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii<\/em> and QseB from Francisella <\/em>spp. Frontiers<\/em>, 2018<\/strong>, 5<\/em>, Article 15. doi.org\/10.3389\/fmolb.2018.00015<\/a><\/p>\n\n\n\n

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120. Melander, R.J., Zurawski, D.V., and Melander, C. Narrow-Spectrum Antibacterial Agents. (Invited review). MedChemComm, <\/em>2018<\/strong>, 9, <\/em>12-21. <\/em>doi.org\/10.1039\/C7MD00528H<\/a><\/p>\n\n\n\n

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119. Robb, A.J., Vinogradov, S., Anderson, E., Blackledge, M.S. Melander, C., and Hvastkovs, E.G. Electrochemical Detection of Small Molecule Induced Biofilm Dispersion. Electrochemica Acta, <\/em>2018<\/strong>, 268, <\/em>276-282.<\/em> doi.org\/10.1016\/j.electacta.2018.02.113<\/a><\/p>\n\n\n\n

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118. Barker, W. T., Martin, S.E., Chandler, C.E., Nguyen, T.V., Harris, T.L., Goodell, C., Melander, R.J., Doi, Y., Ernst, R. K., Melander, C. Small Molecule Adjuvants that Suppress Both Chromosomal and mcr-1 <\/em>Encoded Colistin-Resistance and Amplify Colistin Efficacy in Polymyxin-Susceptible Bacteria. Bioorganic and Medicinal Chemistry, <\/em>2017<\/strong>, 25, <\/em>5749-5753. doi.org\/10.1016\/j.bmc.2017.08.055<\/a><\/p>\n\n\n\n

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117. Milton, M.E., Allen, C.L., Feldmann, E.A., Bobay, B.G., Stephens, M.D., Melander, R.J., Theisen, K.E., Zeng, D., Thopmson, R.J., Melander, C.<\/strong>, Cavanagh, J. Structure of the Francisella Response Regulator QseB Receiver Domain, and Characterization of QseB Inhibition by Antibiofilm 2-Aminoimidazole-Based Compounds. Molecular Microbiology, <\/em>2017<\/strong>, 106, <\/em>223-235.  doi.org\/10.1111\/mmi.13759<\/a><\/p>\n\n\n\n

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116. Jeon, A.B., Obregon-Henao, A., Ackart, D.F., Podell, B.K., Belardinelli, J., Jackson, M., Nguyen, T.V., Blackledge, M.S., Melander, R.J., Melander, C., Johnson, B., Abramovitch, R., and Basaraba, R.J. 2-Aminoimidazoles Potentiate \u00df-Lactam Antimicrobial Activity against Mycobacterium tuberculosis<\/em> by Reducing \u00df-Lactamase Secretion and Increasing Cell Wall Permeability. PLOS One<\/em>, 2017<\/strong>, 12, <\/em>e0180925. <\/em>doi.org\/10.1371\/journal.pone.0180925<\/a><\/p>\n\n\n\n

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115. Byrne-Nash, R., Lucero, D.M., Osbaugh, N.A., Melander, R.J., Melander, C., and Feldheim, D.L. Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered Through Small Molecule Variable Ligand Display. Bioconjugate Chemistry,<\/em> 2017<\/strong>, 28, <\/em>1807-1810. <\/em>doi.org\/10.1021\/acs.bioconjchem.7b00199<\/a><\/p>\n\n\n\n

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114. Melander, R.J. and Melander, C.<\/strong> The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach. ACS Infectious Diseases<\/em>, 2017<\/strong>, 3, <\/em>559-563. <\/em>doi.org\/10.1021\/acsinfecdis.7b00071<\/a><\/p>\n\n\n\n

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113. Garcia, S.S., Blackledge, M.S., Michalek, S., Su, L., Ptacek, T., Eipers, P., Morrow, C., Lefkowitz, E.J., Melander, C., and Wu, H. Selective Targeting of Streptococcus mutans<\/em> by a Novel Small Molecule Preserves the Oral Microbiome in vivo<\/em>. Journal of Dental Research<\/em>, 2017<\/strong>, 96, <\/em>807-814. <\/em>doi.org\/10.1177\/0022034517698096<\/a><\/p>\n\n\n\n

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112. Melander, R.J., and Melander, C. Antibiotic Adjuvants. Topics in Medicinal Chemistry: Antibacterials (Springer)<\/em>. 2017<\/strong>, 25, 89-118. doi.org\/10.1007\/7355_2017_10<\/a><\/p>\n\n\n\n

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111. Nguyen, T.V., Blackledge, M.S., Lindsey, E.A., Minrovic, B.M., Ackart, D.F., Jeon, A.B., Obregon-Henao, A., Melander, R.J., Basaraba, R.J., and Melander, C. The Discovery of 2-Aminobenzimidazoles that Sensitize M. smegmatis <\/em>and M. tuberculosis <\/em>to \u00df-Lactam Antibiotics in a Pattern Distinct from \u00df-Lactamase Inhibitors. Angewandte Chemie, <\/em>2017<\/strong>, 56<\/em> (14), 3940-3944. <\/em>doi.org\/10.1002\/anie.201612006<\/a><\/p>\n\n\n\n

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110. Draughn, C. L., Allen, C.L., Routh, P.A., Stone, M.R., Kirker, K.R., Schuchman, R.M., Linder, K.E., Baynes, R.E., Garth, J., Melander, C.<\/strong>, Pollard, A., and Cavanagh, J. Evaluation of a 2-Aminoimidazole Variant as Adjuvant Treatment for Dermal Bacterial Infections. Drug Design, Development, and Therapy<\/em>. 2017<\/strong>, 11, <\/em>153-162. <\/em>doi.org\/10.2147\/DDDT.S111865<\/a><\/p>\n\n\n\n

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109. Huggins. W.M., Minrovic, B.M., Corey, B.W., Jacobs, A.C., Melander, R.J., Zurawski, D.V., and Melander, C. 1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics Against Multi-Drug Resistant Acinetobacter baumannii<\/em>. ACS Medicinal Chemistry Letters, <\/em>2017<\/strong>, 8 <\/em>(1), 27-31. <\/em>doi.org\/10.1021\/acsmedchemlett.6b00296 <\/a><\/p>\n\n\n\n

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108. Corey, W., Thompson, M.G., Hittle, L.E., Jacobs, A.C., Asafo-Adjei, E.A., Dunn, T.M., Huggins, W.M., Melander, R.J., Melander, C.<\/strong>, Ernst, R.K., and Zurawski, D.V. 1,2,4-Triazolidine-3-thiones Have Specific Activity Against Acinetobacter baumannii <\/em>Amongst Common Nosocomial Pathogens. ACS Infectious Diseases<\/em>, 2017<\/strong>, 3 <\/em>(1), 62-71. <\/em>doi.org\/10.1021\/acsinfecdis.6b00133<\/a><\/p>\n\n\n\n

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107. Melander, R.J. and Melander, C. Inhibitors of Biofilm Production. Antibiotic Drug Discovery: New Targets and Molecular Entities<\/i> (The Royal Society of Chemistry).<\/em> 2017<\/strong>, 43-75. doi.org\/10.1039\/9781782629870-00043<\/a><\/p>\n\n\n\n

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106. Stephens, M.D., Yodsanit, N., and Melander, C. <\/strong>Potentiation of the Fosmidomycin Analogue FR 900098 with Substituted 2-Oxazolines Against Francisella novicida. MedChemComm. <\/em>2016<\/strong>, 7, 1952-1956. <\/em>doi.org\/10.1039\/C6MD00365F<\/a><\/p>\n\n\n\n

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105. Melander, R.J., Liu, H.-B., Stephens, M.D., Bewley, C.A., and Melander, C. Marine Sponge Alkaloids as a Source of Anti-Bacterial Adjuvants. Bioorganic and Medicinal Chemistry Letters, <\/em>2016<\/strong>, 26 <\/em>(24), 5863-5866. <\/em>doi.org\/10.1016\/j.bmcl.2016.11.018<\/a><\/p>\n\n\n\n

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104. Stephens, M.D., Yodsanit, N., and Melander, C. <\/strong>Analogues of the Natural Product Ethyl N-(2-Phenethyl) Carbamate as Potent Biofilm Inhibitors of Methicillin Resistant Staphylococcus aureus<\/em>. Organic and Biomolecular Chemistry<\/em>. 2016<\/strong>, 14, 6853 – 6856. <\/em>doi.org\/10.1039\/c6ob00706f<\/a><\/p>\n\n\n\n

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103. Stephens, M.D., Hubble, V.B., Ernst, R.K., Melander, R.J., Cavanagh, J., and Melander, C.<\/strong> Potentiation of Francisella<\/em> Resistance to Conventional Antibiotics through Small Molecule Adjuvants. MedChemComm <\/em>(Special Issue on Antibiotic Resistance). 2016<\/strong>, 7 <\/em>(1), 128-131. <\/em>doi.org\/10.1039\/C5MD00353A<\/a><\/p>\n\n\n\n

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102. Brackett, C.M., Furlani, R.E., Anderson, R.G., Krishnamurthy, A., Melander, R.J., Moskowitz, S.M., Ernst, R.K. and Melander, C.<\/strong> Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity. Tetrahedron <\/em>(Special Issue on Antibiotic Resistance), 2016<\/strong>, 72 <\/em>(25), 128-131. <\/em>doi.org\/10.1016\/j.tet.2015.09.019<\/a><\/p>\n\n\n\n

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101. Pan, W., Fan, W., Wu, H., Melander, C., and Liu, C. A New Small Molecule Inhibits Streptococcus mutans<\/em> Biofilms in vitro<\/em> and in vivo<\/em>. Journal of Applied Microbiology. <\/em>2015<\/strong>, 119 <\/em>(5), 3406-3409. <\/em>doi.org\/10.1111\/jam.12940<\/a><\/p>\n\n\n\n

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100. Furlani, R.E., Richardson, M.A., Podell, B.K., Ackart, D.F., Haugen, J.D., Melander, J.J., Basaraba, R.J., and Melander, C. Second Generation 2-Aminoimidazole Based Advanced Glycation End Product Inhibitors and Breakers. Bioorganic and Medicinal Chemistry Letters (25th anniversary). <\/em>2015<\/strong>, 25 <\/em>(21), 4820-4823. doi.org\/10.1016\/j.bmcl.2015.06.080<\/a><\/p>\n\n\n\n

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99. Garrido, C., Simpson, C.A., Dahl, N.P., Bresee, J., Whitehead, D.C., Lindsey, E.A., Harris, T.L., Smith, C.A., Carter, C.J., Feldheim, D.L., Melander, C, and Margolis, D.M. Gold Nanoparticles to Improve HIV Drug Delivery. Future Medicinal Chemistry, <\/em>2015<\/strong>, 7 <\/em>(9), 1097-1107. doi.org\/10.4155\/fmc.15.57<\/a><\/p>\n\n\n\n

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98. Richardson, M.A., Furlani, R.E., Podell, B.K., Ackart, D.F., Haugen, J.D., Melander, R.J., Melander, C., <\/strong>and Basaraba, R.J. Inhibition and Breaking of Advanced Glycation End-Products with Bis-2-Aminoimidazole Derivatives. Tetrahedron Letters, <\/em>2015<\/strong>, 56 <\/em>(23), 3406-3409. doi.org\/10.1016\/j.tetlet.2015.01.122<\/a><\/p>\n\n\n\n

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97. Melander, R.J., and Melander, C. From Worms to Targeting Virulence Factors (Invited Commentary). Chemistry and Biology, <\/em>2015<\/strong>, 22<\/em> (4), 436-437. doi.org\/10.1016\/j.chembiol.2015.04.005<\/a><\/p>\n\n\n\n

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96. Stowe, S.D., Thompson, R.J., Peng, L., Su, Z., Blackledge, M.S., Draughn G.L., Coe, W.H., Johannes, E., Lapham, V.K., Mackenzie, J., Melander, C., and Cavanagh, J. Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Gram-Negative Pathogen, Acinetobacter baumannii<\/em>. Current Drug Delivery, <\/em>2015<\/strong>, 12<\/em> (2), 223-30. <\/em>doi.org\/10.2174\/1567201811666140924125740<\/a><\/p>\n\n\n\n

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95. Wahome, P.G., Beauchesne, K.R., Cato-Pedone, A., Cavanagh, C., Melander, C., Zimba, P., and Moeller, P.D.R. Augmenting Anti-Cancer Natural Products with a Small Molecule Adjuvant. Marine Drugs, <\/em>2015<\/strong>, 13<\/em> (1), 65-75. <\/em>doi.org\/10.3390\/md13010065<\/a><\/p>\n\n\n\n

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94. Melander, R.J. and Melander, C. Innovative Strategies for Combating Biofilm-based Infections Biofilm-based Healthcare-associated Infections (Springer)<\/em>. 2015<\/strong>, 831, 69-91. doi.org\/10.1007\/978-3-319-09782-4_6<\/a><\/p>\n\n\n\n

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93. Gifford, J.C., Bresee, J., Carter, C.J., Wang, G., Melander, R., Melander, C., and Feldheim, D.L. Thiol-Modified Gold Nanoparticles for the Inhibition of M. smegmatis<\/em>. Chemical Communications, <\/em>2014<\/strong>, 50<\/em> (100), 15860-15863. doi.org\/10.1039\/c4cc06236a<\/a><\/p>\n\n\n\n

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92. Brackett, C.M., Melander, R.J., An, I.H., Krisnamurthy, A., Thompson, R.J., Cavanagh, J., and Melander, C. Small Molecule Suppression of \u00df-Lactam Resistance in Multi-drug Resistant Gram-negative Pathogens. Journal of Medicinal Chemistry, <\/em>2014<\/strong>, 57<\/em> (17), 7450-7458. <\/em>doi.org\/10.1021\/jm501050e<\/a><\/p>\n\n\n\n

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91. Wright, C.J., Wu, H., Melander, R.J., Melander, C, and Lamont, R.J. Disruption of Heterotypic Community Development by Porphyromonas gingivalis<\/em> with Small Molecule Inhibitors. Molecular Oral Microbiology, <\/em>2014<\/strong>, 29<\/em> (5), 185-193. <\/em>doi.org\/10.1111\/omi.12060<\/a><\/p>\n\n\n\n

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90. Melander, R.J., Minvielle, M.J., and Melander, C. Controlling Bacterial Behavior with Indole-containing Natural Products and Derivatives (invited review). Tetrahedron<\/em>, 2014<\/strong>, 70 <\/em>(37), 6363-6372. <\/em>doi.org\/10.1016\/j.tet.2014.05.089<\/a><\/p>\n\n\n\n

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89. Bresee, J., Bond, C.M., Worthington, R.J., Smith, C.A., Carter, C.J., Simpson, C.A., Wang, G., Hartman, J., Osbaugh, N.A., Melander, C., and Feldheim, D.L. Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics. Journal of the American Chemical Society, <\/em>2014<\/strong>, 136<\/em> (14), 5295-5300. <\/em>doi.org\/10.1021\/ja408505n<\/a><\/p>\n\n\n\n

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88. Ackart, D.F., Lindsey, E.A., Podell, B.K., Melander, R.J., Basaraba, R.J., and Melander, C. <\/em>Reversal of Mycobacterium tuberculosis<\/em> Phenotypic Drug Resistance by 2-Aminoimidazole Based Small Molecules. FEMS Pathogens and Disease, <\/em>2014<\/strong>, 70<\/em> (3), 370-378. <\/em>doi.org\/10.1111\/2049-632X.12143<\/a><\/p>\n\n\n\n

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87. Ackart, D.F., Parks, Q.M., Kirk, N.M., Podell, B.K., Melander, C., Orme, I.M., Leid, J.G., Nick, J.A., and Basaraba, R.J. Expression of Antimicrobial Drug Tolerance by Attached Communities of Mycobacterium tuberculosis. FEMS Pathogens and Disease, <\/em>2014<\/strong>, 70<\/em> (3), 359-369. <\/em>doi.org\/10.1111\/2049-632X.12144<\/a><\/p>\n\n\n\n

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86. Worthington, R.J, Richards, J.J., and Melander, C. Non-Microbicidal Control of Bacterial Biofilms with Small Molecules. Anti-Infective Agents<\/em>, 2014<\/strong>, 12 <\/em>(1), 120-38. doi.org\/10.2174\/22113525113119990107<\/a><\/p>\n\n\n\n

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85. Harris, T.L., Worthington, R.J., Hittle, L.E., Zurawski, D.V., Ernst, R.K., and Melander, C. <\/strong>Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance. ACS Chemical Biology, <\/em>2014<\/strong>, 9 <\/em>(1), 127-7. <\/em>doi.org\/10.1021\/cb400490k<\/a><\/p>\n\n\n\n

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84. Minvielle, M.J., Eguren, K., and Melander, C. Highly Active Modulators of Indole Signaling to Alter Pathogenic Behavior in Gram-Negative and Gram-Positive Bacteria. Chemistry: A European Journal, <\/em>2013<\/strong>, 19 <\/em>(51), 17595-602. <\/em>doi.org\/10.1002\/chem.201303510<\/a><\/p>\n\n\n\n

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83. Blackledge, M.S., Worthington, R.J., and Melander, C. Biologically-Inspired Strategies for Combating Bacterial Biofilms. Current Opinion in Pharmacology<\/em>, 2013<\/strong>, 13 <\/em>(5), 699-706. doi.org\/10.1016\/j.coph.2013.07.004<\/a><\/p>\n\n\n\n

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82. Minvielle, M.J., Bunders, C.A., and Melander, C. Indole\/triazole Conjugates are Selective Inhibitors and Inducers of Bacterial Biofilms. MedChemComm, <\/em>2013<\/strong>, 4 <\/em>(6), 916-919. <\/em>doi.org\/10.1039\/C3MD00064H<\/a><\/p>\n\n\n\n

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81. Worthington, R.J. and Melander, C. Overcoming Resistance to \u03b2-Lactam Antibiotics (JOCSynopsis). Journal of Organic Chemistry, <\/em>2013<\/strong>, 78 <\/em>(9), 4207-4213. <\/em>doi.org\/10.1021\/jo400236f<\/a><\/p>\n\n\n\n

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80. Blackledge, M.S. and Melander, C. Programmable DNA-binding Small Molecules. Bioorganic and Medicinal Chemistry, <\/em>2013<\/strong>, 21 <\/em>(20), 6101-14. <\/em>doi.org\/10.1016\/j.bmc.2013.04.023<\/a><\/p>\n\n\n\n

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79. Worthington, R.J., Blackledge, M.S., and Melander, C. Small Molecule Inhibition of Bacterial Two-Component Systems to Combat Antibiotic Resistance and Virulence. Future Medicinal Chemistry, <\/em>2013<\/strong>, 5 <\/em>(11), 1265-1284. <\/em>doi.org\/10.4155\/fmc.13.58<\/a><\/p>\n\n\n\n

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78. Worthington, R.J. and Melander, C. Combination Approaches to Combat Multi-Drug Resistant Bacteria. Trends in Biotechnology<\/em>, 2013<\/strong>, 31 <\/em>(3), 177-184. doi.org\/10.1016\/j.tibtech.2012.12.006<\/a><\/p>\n\n\n\n

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77. Furlani, R., Yeagley, A.A., and Melander, C. A Flexible Approach to 1,4-Disubstituted 2-Aminoimidazoles that Inhibit and Disperse Biofilms and Potetiate the Effects of \u03b2-Lactams against Multi-Drug Resistant Bacteria. European Journal of Medicinal Chemistry<\/em>, 2013<\/strong>, 62<\/em>, 59-70. <\/em>doi.org\/10.1016\/j.ejmech.2012.12.005<\/a><\/p>\n\n\n\n

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76. Yeagley, A.A., Su, Z., McCullough, K., Worthington, R. J., and Melander, C. N-Substituted 2-Aminoimidazole Inhibitors of MRSA Biofilm Formation Accessed Through Direct 1,3-Bis(tert-<\/em>butoxycarbonyl)guanidine Cyclization. Organic and Biomolecular Chemistry,<\/em> 2013<\/strong>, 11<\/em> (1), 130-137. <\/em>doi.org\/10.1039\/C2OB26469B<\/a><\/p>\n\n\n\n

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75. Thompson, R.J., Bobay, B.G., Stowe, S.D., Peng, L. Su, Z., Actis, L.A., Melander, C., and Cavanagh, J. Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Anti-Biofilm Agent. Biochemistry<\/em>, 2012<\/strong>, 51 <\/em>(49), 9776-9778. <\/em>doi.org\/10.1021\/bi3015289<\/a><\/p>\n\n\n\n

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74. Harris, T.L., Worthington, R.J., and Melander, C. Potent Small Molecule Suppression of Oxacillin Resistance in methicillin-resistant Staphylococcus aureus<\/em>. Angewandte Chemie, <\/em>2012<\/strong>, 51<\/em> (45), 11254-11257. <\/em>doi.org\/10.1002\/anie.201206911<\/a><\/p>\n\n\n\n

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73. Lindsey, E.A., Brackett, C.M., Mullikin, T., Alcaraz, C., and Melander, C. The Discovery of N-1 Substituted 2-Aminobenzimidazoles as Zinc-Dependent S. aureus<\/em> Biofilm Inhibitors. MedChemComm<\/em>, 2012<\/strong>, 3<\/em> (11), 1462-1465. doi.org\/10.1039\/C2MD20244A<\/a><\/p>\n\n\n\n

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72. Su, Z., Yeagley, A.A., Su, R., Peng, L., and Melander, C. Structural Studies on 4,5-Disubstituted-2-Aminoimidazole-Based Biofilm Modulators that Suppress Bacterial Resistance to \u03b2-Lactams. ChemMedChem<\/em>, 2012<\/strong>, 7<\/em> (11), 2030-2039. <\/em>doi.org\/10.1002\/cmdc.201200350<\/a><\/p>\n\n\n\n

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71. Melander, C and Margolis, D.M. Forcing an Enemy into the Open. Nature Chemistry, <\/em>2012<\/strong>, 4 (9), 692-693. doi.org\/10.1038\/nchem.1444<\/a><\/p>\n\n\n\n

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70. Olson, A.L., Thompson, R.J., Melander, C., and Cavanagh, J. Chemical Shift Assignments and Secondary Structure Prediction of the C-Terminal Domain of the Response Regulator BfmR from Acinetobacter baumannii. Journal of Biomolecular NMR, <\/em>2012<\/strong>, 6 <\/em>(1), 95-8. <\/em>doi.org\/10.1007\/s12104-012-9454-2<\/a><\/p>\n\n\n\n

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69. Worthington, R.J. and Melander, C. Deconvoluting Interspecies Bacterial Communication. Angewandte Chemie<\/em>, 2012<\/strong>, 51<\/em> (26), 6314-6315. doi.org\/10.1002\/anie.201202440<\/a><\/p>\n\n\n\n

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68. Worthington, R.J., Richards, J.J., and Melander, C. Small Molecule Control of Bacterial Biofilms, Organic and Biomolecular Chemistry<\/em>, 2012<\/strong>, 10<\/em> (37), 7457 – 7474. <\/em>doi.org\/10.1039\/c2ob25835h<\/a><\/p>\n\n\n\n

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67. Worthington, R.J., Rogers, S.A., Huigens, R.W., Melander, C., and Ritchie, D.F. Foliar Applied Small Molecule That Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria<\/em> on Peppers. Plant Disease<\/em>, 2012 <\/strong>96<\/em> (11), 1638-1644.<\/em> doi.org\/10.1094\/PDIS-02-12-0190-RE<\/a><\/p>\n\n\n\n

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66. Worthington, R.J., Bunders, C.A., Reed, C.S., and Melander, C. Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella penumoniae<\/em>. ACS Medicinal Chemistry Letters<\/em>, 2012 <\/strong>3 <\/em>(5), 357-361. <\/em>doi.org\/10.1021\/ml200290p<\/a><\/p>\n\n\n\n

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65. Lindsey, E.A., Worthington, R.J., Alcaraz, C., and Melander, C. 2-Aminopyrimidine as a Novel Scaffold for Biofilm Modulation. Organic and Biomolecular Chemistry, <\/em>2012<\/strong>, 10 <\/em>(13), 2552-2561. <\/em>doi.org\/10.1039\/c2ob06871k<\/a><\/p>\n\n\n\n

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64. Su, Z., Peng, L., and Melander, C. A Modular Approach to the Synthesis of 1,4,5-Substituted-2-Aminoimidazoles. Tetrahedron Letters,<\/em> 2012<\/strong>, 53 <\/em>(10), 1204-1206.<\/em> doi.org\/10.1016\/j.tetlet.2011.12.090<\/a><\/p>\n\n\n\n

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63. Budhathoki-Uprety, J., Peng, L., Melander, C., and Novak, B.M. Synthesis of Guanidinium Functionalized Polycarbodiimides and their Antibacterial Activities. ACS Macro Letters<\/em>, 2012 <\/strong>1 <\/em>(3), 370-374. <\/em>doi.org\/10.1021\/mz200116k<\/a><\/p>\n\n\n\n

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62. Olson, A.L., Bobay, B.G., Melander, C, and Cavanagh, J. 1<\/sup>H, 13<\/sup>C, and 15<\/sup>N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis<\/em>. Biomolecular NMR Assignments, <\/em>2012<\/strong>, 6<\/em>(1), 95-98. doi.org\/10.1007\/s12104-011-9333-2<\/a><\/p>\n\n\n\n

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61. Stowe, S.D., Tucker, A.T, Rogers, S.A., Richards, J.J., Melander, C., and Cavanagh, J. Evaluation of the Toxicity of  2-Aminoimidazole Antibiofilm Agents using both Cellular and Model Organism Systems. Drug and Chemical Toxicology<\/em>, 2012<\/strong>, 35 <\/em>(3), 310-315. doi.org\/10.3109\/01480545.2011.614620<\/a><\/p>\n\n\n\n

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60. Bunders, C.A., Minvielle, M.J., Worthington, R.J., Ortiz, M., Cavanagh, J., and Melander, C. Intercepting Bacterial Indole Signaling with Flustramine Derivatives. Journal of the American Chemical Society,<\/em> 2011<\/strong>, 133<\/em> (50), 20160-20163. doi.org\/10.1021\/ja209836z<\/a><\/p>\n\n\n\n

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59. Stowe, S.D., Richards, J.J., Tucker, A.T., Thompson, R., Melander, C, and Cavanagh, J. Anti-Biofilm Compounds Derived from Marine Sponges. Marine Drugs<\/em>, 2011<\/strong>, 9<\/em> (11), 2010-2035. doi.org\/10.3390\/md9102010<\/a><\/p>\n\n\n\n

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58. Su, Z., Peng, L., Worthington, R.J., and Melander, C. Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual Antibiofilm\/Antibiotic Resensitization Activity. ChemMedChem, <\/em>2011<\/strong>, 6<\/em>, 2243-2251. <\/em>doi.org\/10.1002\/cmdc.201100316<\/a><\/p>\n\n\n\n

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57. Harris, T., Worthington, R.J., and Melander, C. A Facile Synthesis of 1,5-Disubstituted-2-Aminoimidazoles: Antibiotic and Antibiofilm Activity of a First Generation Library. Bioorganic and Medicinal Chemistry Letters, <\/em>2011<\/strong>, 21 <\/em>(15), 4516-4519. <\/em>doi.org\/10.1016\/j.bmcl.2011.05.123<\/a><\/p>\n\n\n\n

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56. Bunders, C.A., Cavanagh, J., and Melander, C. Flustramine Inspired Synthesis and Biological Evaluation of Pyrroloindoline Triazole Amides as Novel Inhibitors of Bacterial Biofilms. Organic and Biomolecular Chemistry,<\/em> 2011<\/strong>, 9<\/em>, 5476-5481. <\/em>doi.org\/10.1039\/c1ob05605k<\/a><\/p>\n\n\n\n

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55. Bresee, J., Maier, K.E., Boncella, A.E., Melander, C.<\/strong>, and Feldheim, D.L. Growth Inhibition of Staphylococcus aureus<\/em> by Mixed Monolayer Gold Nanoparticles. Small<\/em>, 2011<\/strong>, 7<\/em> (14), 2027-2031. <\/em>doi.org\/10.1002\/smll.201100420<\/a><\/p>\n\n\n\n

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54. Peng, L., DeSousa, J., Su, Z., Novak, B.M., Nevzorov, A.A., Garland, E.R., and Melander, C. Inhibition of Acinetobacter baumannii <\/em>Biofilm Formation on a Methacrylate Polymer Containing a 2-Aminoimidazole Subunit. Chemical Communications<\/em>, 2011, <\/em><\/strong>47<\/em> (17), 4896-4898. doi.org\/10.1039\/C1CC10691K<\/a><\/p>\n\n\n\n

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53. Liu, C., Worthington, R.J., Melander, C., and Wu, H. A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans<\/em> in Multispecies Biofilms. Antimicrobial Agents and Chemotherapy, <\/em>2011<\/strong>, 55<\/em>(6), 2679-2687. <\/em>doi.org\/10.1128\/AAC.01496-10<\/a><\/p>\n\n\n\n

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52. Rogers, S.A., Lindsey, E.A, Whitehead, D.C., Mullikin, T. and Melander, C. Synthesis and Biological Evaluation of 2-Aminoimidazole\/Carbamate Hybrid Anti-biofilm and Antimicrobial Agents. Bioorganic and Medicinal Chemistry Letters, <\/em>2011<\/strong>, 21 <\/em>(4), 1257-1260. doi.org\/10.1016\/j.bmcl.2010.12.057<\/a><\/p>\n\n\n\n

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51. Reyes, S., Huigens, R.W., Su, Z., Simon, M.L., and Melander, C. Synthesis and Biological Activity of 2-Aminoimidazole Triazoles Accessed by Suzuki-Miyaura Cross-Coupling, Organic and Biomolecular Chemistry, <\/em>2011<\/strong>, 9<\/em>(8), 3041-3049. doi.org\/10.1039\/C0OB00925C<\/a><\/p>\n\n\n\n

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50. Bresee, J., Maier, K.E., Melander, C., and Feldheim, D.L. Identification of Antibiotics Using Small Molecule Variable Ligand Display on Gold Nanoparticles, Chemical Communications<\/em>, 2010<\/strong>, 46<\/em> (40), 7516-7518. <\/em>doi.org\/10.1039\/C0CC02663H<\/a><\/p>\n\n\n\n

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49. Reed, C.S., Huigens, R.W., Rogers, S.A., and Melander, C. Modulating the Development of E. coli<\/em> Biofilms with 2-Aminoimidazoles, Bioorganic and Medicinal Chemistry Letters,<\/em> 2010<\/strong>, 20<\/em> (21), 6310-6312. doi.org\/10.1016\/j.bmcl.2010.08.075<\/a><\/p>\n\n\n\n

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48. Rogers, S.A., Whitehead, D.C., Mullikin, T., and Melander, C. Synthesis and Bacterial Biofilm Inhibition Studies of Ethyl N-(2-Phenethyl) Carbamate Derivatives. Organic and Biomolecular Chemistry<\/em>, 2010<\/strong>, 8<\/em>, 3857-3859. doi.org\/10.1039\/C0OB00063A<\/a><\/p>\n\n\n\n

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47. Bunders, C., Richards, J.J., and Melander, C. Identification of Aryl 2-Aminoimidazoles as Biofilm Inhibitors of Gram-Negative Bacteria. Bioorganic and Medicinal Chemistry Letters,<\/em> 2010<\/strong>, 20 <\/em>(12), 3797-3800. <\/em>doi.org\/10.1016\/j.bmcl.2010.04.042<\/a><\/p>\n\n\n\n

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46. Su, Z., Rogers, S.A., McCall, W.S., Smith, A.C., Ravishankar, S., Mullikin, T., and Melander, C. A Nitroenolate Approach to the Synthesis of 4,5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity. Organic and Biomolecular Chemistry<\/em>, 2010<\/strong>, 8<\/em>(12), 2814-2822. doi.org\/10.1039\/C001479F<\/a><\/p>\n\n\n\n

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45. Rogers, S.A., Huigens, R.W., Cavanagh, J., and Melander, C. Synergistic Effects Between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents. Antimicrobial Agents and Chemotherapy<\/em>, 2010<\/strong>, 54<\/em>(5), 2112-2118. doi.org\/10.1128\/AAC.01418-09<\/a><\/p>\n\n\n\n

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44. Heinecke, C.L. and Melander, C. Analysis of Kinamycin D Mediated DNA Cleavage. Tetrahedron Letters<\/em>, 2010<\/strong>, 51<\/em> (11), 1455-1458. doi.org\/10.1016\/j.tetlet.2009.12.142<\/a><\/p>\n\n\n\n

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43. Huigens, R.W., Reyes, S., Reed, C.S., Bunders, C., Rogers, S.A., Steinhauer, A.T., and Melander, C. The Chemical Synthesis and Antibiotic Activity of a Diverse Library of 2-Aminobenzimidazole Small Molecules Against MRSA and Multidrug-Resistant A. baumannii<\/em>. Bioorganic and Medicinal Chemistry<\/em>, 2010<\/strong>, 18<\/em> (2), 663-674. doi.org\/10.1016\/j.bmc.2009.12.003<\/a><\/p>\n\n\n\n

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42. Rogers, S.A., Bero, J.D., and Melander, C. Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents. ChemBioChem<\/em>, 2010<\/strong>, 11<\/em> (3), 396-410. doi.org\/10.1002\/cbic.200900617<\/a><\/p>\n\n\n\n

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41. Richards, J.J. and Melander, C. Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance. Anti-Infective Agents in Medicinal Chemistry<\/em>, 2009<\/strong>, 8<\/em>, 295-314. doi.org\/10.2174\/187152109789760135<\/a><\/p>\n\n\n\n

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40. Richards, J.J. and Melander, C. Controlling Bacterial Biofilms. ChemBioChem<\/em>, 2009<\/strong>, 10<\/em> (14), 2287-2294. doi.org\/10.1002\/cbic.200900317<\/a><\/p>\n\n\n\n

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39. Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.; Ballard, T.E.; Cavanagh, J.; and Melander, C. Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans<\/em> Toxicity. Journal of Medicinal Chemistry<\/em>, 2009<\/strong>, 52 (15), 4582-4585. doi.org\/10.1021\/jm900378s<\/a><\/p>\n\n\n\n

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38. Rogers, S.A., Huigens, R.W., and Melander, C. A 2-Aminobenzimidazole that Inhibits and Disperses Gram-Positive Biofilms Through a Zinc-Dependent Mechanism. Journal of the American Chemical Society<\/em>, 2009<\/strong>, 131 (29), 9868\u20139869. doi.org\/10.1021\/ja9024676<\/a><\/p>\n\n\n\n

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37. Melander, C., Moeller, P.D.R., Ballard, T.E., Richards, J.J., Huigens, R.W., and Cavanagh, J. Evaluation of Dihydrooroidin as an Antifouling Additive in Marine Paint. International Biodeterioration & Biodegradation<\/em>. 2009<\/strong>, 63, 529-532. doi.org\/10.1016\/j.ibiod.2008.08.009<\/a><\/p>\n\n\n\n

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36. Ballard, T.E., Richards, J.J., Aquino, A., Reed, C.S. and Melander, C. Anti-biofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation. Journal of Organic Chemistry<\/em>, 2009<\/strong>, 74<\/em> (4), 1755-1758. doi.org\/10.1021\/jo802260t<\/a><\/p>\n\n\n\n

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35. Huigens, R.W., Rogers, S.A., Steinhauer, A.T., and Melander, C. Inhibition of Acinetobacter baumannii<\/em>, Staphylococcus aureus, <\/em>and Pseudomonas aeruginosa<\/em> Biofilms with a Class of TAGE-Triazole Conjugates. Organic and Biomolecular Chemistry,<\/em> 2009<\/strong>, 7<\/em> (4), 794-802. doi.org\/10.1039\/b817926c<\/a><\/p>\n\n\n\n

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34. Rogers, S.A., Krayer, M., Lindsey, J.S., and Melander, C. Tandem Dispersion and Killing of Bacteria from a Biofilm. Organic and Biomolecular Chemistry,<\/em> 2009<\/strong>, 7<\/em> (3), 603-606. doi.org\/10.1039\/b817923a<\/a><\/p>\n\n\n\n

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33. Ballard, T. E., Richards, J.J., Wolfe, A.L., and Melander, C. Synthesis and Anti-biofilm Activity of a Second Generation Reverse Amide Oroidin Library: An SAR Study. Chemistry a European Journal<\/em>, 2008<\/strong>, 14<\/em> (34), 10745-10761. doi.org\/10.1002\/chem.200801419<\/a><\/p>\n\n\n\n

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32. Richards, J.J., Reed, C.S., and Melander, C. Effects of N<\/em>-Pyrrole Substitution on the Anti-Biofilm Activities of Oroidin Derivatives Against Acinetobacter baumannii<\/em>. Bioorganic and Medicinal Chemistry Letters<\/em>, 2008<\/strong>, 18<\/em> (15), 4325-4327. doi.org\/10.1016\/j.bmcl.2008.06.089<\/a><\/p>\n\n\n\n

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31. Richards, J.J. and Melander, C. Synthesis of a 2-Aminoimidazole Library for Anti-Biofilm Screening Utilizing the Sonogashira Reaction. Journal of Organic Chemistry<\/em>, 2008, <\/strong>73 <\/em>(13), 5191-5193. doi.org\/10.1021\/jo800618q<\/a><\/p>\n\n\n\n

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30. Rogers, S.A. and Melander, C. Construction and Screening of a 2-Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms Across Order, Class, and Phylum. Angewandte Chemie,<\/em> 2008<\/strong>, 47<\/em> (28), 5229-5231. doi.org\/10.1002\/anie.200800862<\/a><\/p>\n\n\n\n

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29. Bowman, M.C., Ballard, T.E., Ackerson, C.J., Feldheim, D.J., Margolis, D.M., and Melander, C. Inhibition of HIV Fusion with Multivalent Gold Nanoparticles. Journal of the American Chemical Society,<\/em> 2008<\/strong>, 130<\/em> (22), 6896-6897. doi.org\/10.1021\/ja710321g<\/a><\/p>\n\n\n\n

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28. Ballard, T.E. and Melander, C. Kinamycin-Mediated Cleavage of DNA under Biomimetic Conditions. Tetrahedron Letters<\/em>. 2008<\/strong>, 49, 3157-3161. doi.org\/10.1016\/j.tetlet.2008.03.019<\/a><\/p>\n\n\n\n

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27. Richards, J.J., Ballard, T. E., Huigens, R.W., and Melander, C. Synthesis and Screening of an Oroidin Library Against Pseudomonas aeruginosa<\/em> Biofilms. ChemBioChem<\/em> 2008<\/strong>, 9<\/em> (8), 1267-1279.  doi.org\/10.1002\/cbic.200700774<\/a><\/p>\n\n\n\n

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26. Huigens, R.W., Ma, L., Gambino, C., Basso, A., Moeller, P.D.R., Cavanagh, J., Wozniak, D. J., and Melander, C. Control of Bacterial Biofilms with Marine Alkaloid Derivatives. Molecular BioSystems<\/em>, 2008<\/strong>, 4 <\/em>(6), 614-621. doi.org\/10.1039\/B719989A<\/a><\/p>\n\n\n\n

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25. Richards, J.J., Ballard, T.E., and Melander, C. Inhibition and Dispersion of Pseudomonas aeruginosa <\/em>Biofilms with Reverse Amide 2-Aminoimidazole Oroidin Analogues. Organic and Biomolecular Chemistry<\/em>, 2008<\/strong>, 6 (8), 1356-1363. doi.org\/10.1039\/b719082d<\/a><\/p>\n\n\n\n

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24. Richards, J.J., Huigens, R.W., Ballard, T. E., Basso, A., Cavanagh, J., and Melander, C. Inhibition and Dispersion of Proteobacterial Biofilms. Chemical Communications<\/em>, 2008<\/strong>, 14, 1698-1700. doi.org\/10.1039\/b719802g<\/a><\/p>\n\n\n\n

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23. Burns. V.A., Bobay, B.G., Basso, A., Cavanagh, J., and Melander, C. Targeting RNA with Cysteine-Constrained Peptides. Bioorganic & Medicinal Chemistry Letters<\/em>, 2008<\/strong>, 18<\/em> (2), 565-567. doi.org\/10.1016\/j.bmcl.2007.11.096<\/a><\/p>\n\n\n\n

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22. Huigens, R.W., Richards, J. J., Parise, G.; Ballard, T.E., Zeng, W., Deora, R., Melander, C. Inhibition of Pseudomonas aeruginosa<\/em> Biofilm Formation with Bromoageliferin Analogues. Journal of the American Chemical Society<\/em> 2007,<\/strong> 129<\/em>, (22), 6966-6967. doi.org\/10.1021\/ja069017t<\/a><\/p>\n\n\n\n

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21. Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., Melander, C. Mimicking the Biological Activity of Diazobenzo[b<\/em>]fluorene Natural Products with Electronically Tuned Diazofluorene Analogs. Bioorganic and Medicinal Chemistry Letters<\/em>, 2006<\/strong>, 16, (19), 5148-5151. doi.org\/10.1016\/j.bmcl.2006.07.024<\/a><\/p>\n\n\n\n

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20. Zeng, W., Ballard, T. E., Melander, C. Tuning the Oxidation Properties of Vanadium (V) Through Ligand Stoichiometry. Tetrahedron Letters<\/em> 2006<\/strong>, 47, (33), 5923-5926. doi.org\/10.1016\/j.tetlet.2006.06.051<\/a><\/p>\n\n\n\n

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19. Burnet, R., Melander, C., Puckett, J. W., Son, L. S., Wells, R. D., Dervan, P. B., and Gottesfeld, J. G. DNA sequence-specific polyamides alleviate transcriptional inhibition associated with long GAA.<\/sup>TTC repeats in Friedreich\u2019s ataxia. Proceedings of the National Academy of Science<\/em> 2006<\/strong>, 103<\/em> (91), 11497-11502.  doi.org\/10.1073\/pnas.0604939103<\/a><\/p>\n\n\n\n

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18. Gearha, M. D., Dickinson, L., Ehley, J., Melander, C., Dervan, P. B., Wright, P. E., Gottesfeld, J. M. Inhibition of DNA Binding by Human Estrogen-Related Receptor 2 and Estrogen Receptor a with Minor Groove Binding Polyamides. Biochemistry<\/em> 2005<\/strong>, 44<\/em> (11): 4196-4203.  doi.org\/10.1021\/bi047872o<\/a><\/p>\n\n\n\n

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17. Ylisastigui, L., Coull, J. J., Rucker, V. C., Melander, C., Bosch, R. J., Brodie, S. J., Corey, L., Sodora, D. L., Dervan, P. B., Margolis, D. M. Polyamides Reveal a Role for Repression in Latency within Resting T Cells of HIV-Infected Donors. Journal of Infectious Diseases <\/em>2004,<\/strong> 190<\/em>, (8), 1429-1437. doi.org\/10.1086\/423822<\/a><\/p>\n\n\n\n

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16. Melander, C., Burnett, R., Gottesfeld, J. M. Regulation of Gene Expression with Pyrrole-Imidazole Polyamides. Journal of Biotechnology <\/em>2004,<\/strong> 112<\/em>, (1-2), 195-220. doi.org\/10.1016\/j.jbiotec.2004.03.018<\/a><\/p>\n\n\n\n

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15. Dickinson, L. A., Burnett, R., Melander, C., Edelson, B. S., Arora, P. S., Dervan, P. B., Gottesfeld, J. M. Arresting Cancer Proliferation by Small-Molecule Gene Regulation. Chemistry & Biology <\/em>2004,<\/strong> 11<\/em>, (11), 1583-1594. doi.org\/10.1016\/j.chembiol.2004.09.004<\/a><\/p>\n\n\n\n

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14. Suto, R. K., Edayathumangalam, R. S., White, C., Melander, C., Gottesfeld, J. M., Dervan, P. B., Luger, K. Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-Binding Ligands. Journal of Molecular Biology <\/em>2003,<\/strong> 326<\/em>, (2), 371-380. doi.org\/10.1016\/S0022-2836(02)01407-9<\/a><\/p>\n\n\n\n

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13. Rucker, V. C., Melander, C., Dervan, P. B. Influence of beta-Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove. Helvetica Chimica Acta <\/em>2003,<\/strong> 86<\/em>, (6), 1839-1851. doi.org\/10.1002\/hlca.200390148<\/a><\/p>\n\n\n\n

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12. Rucker, V. C., Foister, S., Melander, C., Dervan, P. B. Sequence Specific Fluorescence Detection of Double Strand DNA. Journal of The American Chemical Society <\/em>2003,<\/strong> 125<\/em>, (5), 1195-1202. doi.org\/10.1021\/ja021011q<\/a><\/p>\n\n\n\n

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11. Dudouet, B., Burnett, R., Dickinson, L. A., Wood, M. R., Melander, C., Belitsky, J. M., Edelson, B., Wurtz, N., Briehn, C., Dervan, P. B., Gottesfeld, J. M. Accessibility of Nuclear Chromatin by DNA Binding Polyamides. Chemistry & Biology <\/em>2003,<\/strong> 10<\/em>, (9), 859-867. doi.org\/10.1016\/j.chembiol.2003.09.001<\/a><\/p>\n\n\n\n

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10. Gottesfeld, J. M., Belitsky, J. M., Melander, C., Dervan, P. B., Luger, K. Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands. Journal of Molecular Biology <\/em>2002,<\/strong> 321<\/em>, (2), 249-263. doi.org\/10.1016\/S0022-2836(02)00598-3<\/a><\/p>\n\n\n\n

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9. Ehley, J. A., Melander, C.<\/strong>, Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides. Molecular and Cellular Biology <\/em>2002,<\/strong> 22<\/em>, (6), 1723-1733. doi.org\/10.1128\/MCB.22.6.1723-1733.2002<\/a><\/p>\n\n\n\n

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8. Coull, J. J., He, G. C., Melander, C., Rucker, V. C., Dervan, P. B., Margolis, D. M. Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides. Journal of Virology <\/em>2002,<\/strong> 76<\/em>, (23), 12349-12354.  doi.org\/10.1128\/JVI.76.23.12349-12354.2002<\/a><\/p>\n\n\n\n

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7. Gottesfeld, J. M., Melander, C.<\/strong>, Suto, R., Raviol, H., Luger, K., Dervan, P. B. Sequence-Specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides. Journal of Molecular Biology <\/em>2001,<\/strong> 309<\/em>, (3), 615-629. doi.org\/10.1006\/jmbi.2001.4694<\/a><\/p>\n\n\n\n

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6. Baliga, R., Baird, E. E., Herman, D. M., Melander, C., Dervan, P. B., Crothers, D. M. Kinetic Consequences of Covalent Linkage of DNA Binding Polyamides. Biochemistry <\/em>2001,<\/strong> 40<\/em>, (1), 3-8. doi.org\/10.1021\/bi0022339<\/a><\/p>\n\n\n\n

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5. Melander, C., Herman, D. M., Dervan, P. B. Discrimination of A\/T Sequences in the Minor Groove of DNA within a Cyclic Polyamide Motif. Chemistry-A European Journal <\/em>2000,<\/strong> 6<\/em>, (24), 4487-4497. <a href="http:\/\/doi.org\/10.1002\/1521-3765(20001215)6:243.0.CO;2-C” target=”_blank” rel=”noopener noreferrer”>doi.org\/10.1002\/1521-3765(20001215)6:24<4487::AID-CHEM4487>3.0.CO;2-C<\/a><\/p>\n\n\n\n

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4. Melander, C.<\/strong>, Horne, D. A. Mutarotation of Tetramethylglucose Catalyzed by Ribonucleosides. Tetrahedron Letters <\/em>1997,<\/strong> 38<\/em>, (5), 713-716. doi.org\/10.1016\/S0040-4039(96)02422-7<\/a><\/p>\n\n\n\n

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3. Melander, C., Horne, D. A. Kinetic Analysis of Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Evidence of Bifunctional Catalysis. Journal of Organic Chemistry <\/em>1997,<\/strong> 62<\/em>, (26), 9295-9297. doi.org\/10.1021\/jo971614y<\/a><\/p>\n\n\n\n

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2. Melander, C., Horne, D. A. Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Journal of Organic Chemistry <\/em>1996,<\/strong> 61<\/em>, (23), 8344-8346. doi\/pdfplus\/10.1021\/jo961331q<\/a><\/p>\n\n\n\n

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1. Kurth, M. J., Randall, L. A. A., Chen, C. X., Melander, C.<\/strong>, Miller, R. B., Mcalister, K., Reitz, G., Kang, R., Nakatsu, T., Green, C. Library-Based Lead Compound Discovery-Antioxidants by an Analogous Synthesis Deconvolutive Assay Strategy. Journal of Organic Chemistry <\/em>1994,<\/strong> 59<\/em>, (20), 5862-5864. doi.org\/10.1021\/jo00099a008<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

192. Gondil, V. S., Stefaniak, M. A., Melander, C. and Dunman, P. M. Penicillin Binding Protein 4: An emerging Staphylococcus aureus therapeutic target. Frontiers in Cellular and Infection Microbiology. Accepted. 191. Zeiler, M. J., Hance, E. M., Melander, R. J., Oliver, A. G., Quave, C. L. and Melander, C. Investigations into the Role of the … Continue reading “Publications”<\/span><\/a><\/p>\n","protected":false},"author":3360,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/users\/3360"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":302,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":1077,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages\/18\/revisions\/1077"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}