{"id":18,"date":"2019-04-08T14:45:06","date_gmt":"2019-04-08T18:45:06","guid":{"rendered":"http:\/\/sites.nd.edu\/melanderlab\/?page_id=18"},"modified":"2026-06-02T13:52:15","modified_gmt":"2026-06-02T17:52:15","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/melanderlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

185. Cowart, L. J., Nemeth, A. M., Jania, L. A., Overly,3<\/sup> M., Ellis, C. F., Koller, B. H., Melander, R. J., Doi, Y., Ernst, R. K. and Melander, C. IMD-0354 Optimization Generates Potent Colistin Adjuvants with In vivo Activity and Reduced Eukaryotic Toxicity. European Journal of Medicinal Chemistry. Accepted<\/em><\/p>\n\n\n\n

\n\n\n\n

184. Kittleson, B., Woo, S., Marquez, L., Zeiler, M., Daher, I., Melander, C. and Quave, C. Growth-Inhibitory Activity of a Clerodane Diterpene from Callicarpa americana<\/em> Leaf Extracts and its Derivatives Against Cutibacterium acnes<\/em>. ACS Infectious Diseases. <\/em>2026<\/strong>, 12, 5, 1662\u20131668. doi.org\/10.1021\/acsinfecdis.5c01116<\/a><\/p>\n\n\n\n

\n\n\n\n

183. Stefaniak, M. A., Gondil, V. S., Gillis, E. P., Nemeth, A. M., Oliver, A. G., Melander, R. J., Dunman, P. M., and Melander, C. Exploration of a Benzothiophene Scaffold for use as Adjuvants with \u03b2-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus<\/em>. RSC Medicinal Chemistry<\/em>. 2026<\/strong>,17, 2444-2454. doi.org\/10.1039\/D5MD01109D<\/a><\/p>\n\n\n\n

\n\n\n\n

182. Kinkead, J., Hondros, A. D., Figg, A., M., Young, M. M., Thompson, R. J., Melander, C. and Cavanagh, J. Recombinant Cytosolic Truncations of Histidine Kinases Retain Function. <\/strong>Microorganisms. <\/em>2026<\/strong>, 14(2), 510. doi.org\/10.3390\/microorganisms14020510<\/a><\/p>\n\n\n\n

\n\n\n\n

181. Cole, A. L., Woolard, K. J., Sorge, A., Melander, C. and Gunn, J. S. A Mouse Model for Studying Chronic Salmonella <\/em>Typhi Infection and Anti-Biofilm Interventions mBio<\/em>. 2026<\/strong>. 17:e03476-25. doi.org\/10.1128\/mbio.03476-25<\/a><\/p>\n\n\n\n

\n\n\n\n

180. Jaimes, F. E., Hondros, A. D., Kinkead, J., Milton, M. E., Thopson, R. J., Figg, A. M., Melander, C. and Cavanagh, J. Mutations in PmrA Drug Resistant Acinetobacter baumannii<\/em> Affect Sensor Kinase-Response Regulator Interaction and Phosphotransfer. Microorganisms<\/em>. 2025<\/strong>, 13(11), 2600. doi.org\/10.3390\/microorganisms13112600<\/a><\/p>\n\n\n\n

\n\n\n\n

179. Mattingly, A. E., Doi, Y. and Melander, C. Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa<\/em> clinical isolates from the cystic fibrosis lung. Microbiology Resource Announcements. <\/em>2025<\/strong>, 0:e00558-25. doi.org\/10.1128\/mra.00558-25<\/a><\/p>\n\n\n\n

\n\n\n\n

178. Lin, B., Woo, S., Philbrick, A., Bacsa, J., Laskey, E., Mehra, N., Gondil, V. S., Mei, J. A., Jones, G., Pavelka, M. S., Dziejman, M., Shutter, D. A., Melander, C., Perritt, A. M., Jakober, R., Shen, Y., Chang, W.-C., Quave, C. L., Dunman, P. M. and Luedemann, G. Testing the Luedemann Hypothesis: The Discovery of Novel Antimicrobials from Slow-Growing Microbes from Nutrient Limited Environments. mSphere, <\/em>2025<\/strong>, 0:e00367-25. <\/em>doi.org\/10.1128\/msphere.00367-25<\/a><\/p>\n\n\n\n

\n\n\n\n

177. Bennett, A. N., Maziarz, J. F., Laipply, B., Cole, A. L., Woolard, K. J., Sorge, A., Zeiler, M. J., Melander, R. J., Melander, C. and Gunn, J. S. Mechanisms of Antibiofilm Compounds JG-1 and M4 Across Multiple Species: Alterations of Protein Interactions Essential to Biofilm Formation. Frontiers in Cellular and Infection Microbiology, <\/em>2025<\/strong>, 15, 1631575. doi.org\/10.3389\/fcimb.2025.1631575<\/a><\/p>\n\n\n\n

\n\n\n\n


176. Crotteau, A. N., Nemeth, A. M., Melander, R. J. and Melander, C. 2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii<\/em>. ACS Medicinal Chemistry Letters<\/em>. 2025<\/strong>, 16, 8, 1562\u20131568. doi.org\/10.1021\/acsmedchemlett.5c00201<\/a><\/p>\n\n\n\n

\n\n\n\n

175. Mattingly, A. E., Li, H., Melander, R. J. and Melander, C. Validation of a Cystic Fibrosis Co-culture Model for the Identification of Dual Acting Compounds with Antibiotic and Antibiotic Adjuvant Properties. ACS Infectious Disease<\/em>s. 2025<\/strong>, 11, 6, 1686\u20131696. doi.org\/10.1021\/acsinfecdis.5c00226<\/a><\/p>\n\n\n\n

\n\n\n\n

174. Butman, H. S., Stefaniak, M. A., Walsh, D. J., Gondil, V. S., Young, M., Crow, A. H., Nemeth, A. M., Melander, R. J., Dunman, P. M., and MelanderC. Phenyl urea based adjuvants for \u03b2-lactam antibiotics against methicillin resistant Staphylococcus aureus<\/em>. Bioorganic and Medicinal Chemistry Letters<\/em>. 2025<\/strong>, 21, 130164. doi.org\/10.1016\/j.bmcl.2025.130164<\/a><\/p>\n\n\n\n

\n\n\n\n

173. Hondros, A., Young, M., Jaimes, F., Kinkead, J., Thompson, R., Melander, C., and Cavanagh, J. Two-component system sensor kinase inhibitors target the ATP-lid of PmrB to disrupt colistin resistance in Acinetobacter baumannii. Biochemistry<\/em>. 2025<\/strong>, 64, 6, 1317\u20131327. doi.org\/10.1021\/acs.biochem.4c00789<\/a><\/p>\n\n\n\n

\n\n\n\n

172. Koller, B. H., Jania, L. A., Li , H., Barker, W. T., Melander, R. J., and Melander, C. Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination. Antimicrobial Agents and Chemotherapy<\/em>. 2024<\/strong>, 68:e00671-24. doi.org\/10.1128\/aac.00671-24<\/a><\/p>\n\n\n\n

\n\n\n\n

171. Gondil, V. S., Butman, H. S., Young, M., Walsh, D. J., Narkhede, Y., Zeiler, M. J., Crow, A. H., Carpenter, M. E., Mardikar, A., Melander, R. J., Wiest, O., Dunman, P.M., and Melander, C. Development of Phenyl-urea Based Small Molecules that Target Penicillin Binding Protein 4. Chemical Biology and Drug Design. <\/em>2024<\/strong>, 103 (6) e14569. <\/em>doi.org\/10.1111\/cbdd.14569<\/a><\/p>\n\n\n\n

\n\n\n\n

170. Nemeth, A. N., Young, M. M., Melander, R. J., Smith, R. D., Ernst, R. K., and Melander, C. <\/sup>Identification of a 2-aminobenzimidazole scaffold that potentiates gram-positive selective antibiotics against gram-negative bacteria. ChemBioChem. <\/em>2024<\/strong>, 25, e2024001. <\/em>doi.org\/10.1002\/cbic.202400127<\/a><\/p>\n\n\n\n

\n\n\n\n

169. Li, H., Nemeth, A. M., Melander, R. J., and Melander, C. Synthesis, Stereochemical Resolution, and Analog Synthesis of Variabiline, an Aporphine Alkaloid that Sensitizes Acinetobacter baumannii<\/em> and Klebsiella pneumoniae <\/em>to Colistin. ACS Infectious Diseases.<\/em> 2024<\/strong>, 10(4), 1339\u20131350. doi.org\/10.1021\/acsinfecdis.4c00026<\/a><\/p>\n\n\n\n

\n\n\n\n

168. Crotteau, A. N., Hubble, V. B., Marrujo, S. A., Mattingly, A. E., Melander, R. J., and Melander, C. Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants. Antibiotics. <\/em>2023<\/strong>, 12(11), 1563. <\/em>doi.org\/10.3390\/antibiotics12111563<\/a><\/p>\n\n\n\n

\n\n\n\n

<\/a>167. Bennett, A. N., Woolard, K. J., Sorge, A., Melander, C., and Gunn, J. S. Spectrum of activity of Salmonella <\/em>anti-biofilm compounds: Evaluation of activity against biofilm-forming ESKAPE pathogens. Biofilm. <\/em>2023<\/strong>, 6, 100158. doi.org\/10.1016\/j.bioflm.2023.100158 <\/a><\/p>\n\n\n\n

\n\n\n\n

166. Harper, E. I., Siroky, M. D.,  Hilliard, T. S., Dominique, G. M., Hammond, C., Liu, Y., Yang, J., Hubble, V. B., Walsh, D. J., Melander, R. J., Melander, C., Blagg, B. S. J., and Stack, M. S. Advanced glycation end products as a potential target for restructuring the ovarian cancer microenvironment: a pilot study. International Journal of Molecular Sciences. <\/em>2023<\/strong>, 24(12), 9804 <\/em>doi.org\/10.3390\/ijms24129804<\/a><\/p>\n\n\n\n

\n\n\n\n

165. Jenul, C., Keim, K., Jens, J., Zeiler, M. J., Schilcher, K., Schurr, M., Melander, C., Phelan, V. V., and Horswill, A. R. Pyochelin Biotransformation Shapes Bacterial Competition. Cell Reports<\/em>, 2023<\/strong>, 42 (6), 112540. doi.org\/10.1016\/j.celrep.2023.112540<\/a><\/p>\n\n\n\n

\n\n\n\n

164. Liu, C., Zhang, H., Peng, X., Blackledge, M. S., Furlani, R. E., Li, H., Su, Z., Melander, R. J., Melander, C., Michalek, S., and Wu H. Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. mBio<\/em>. 2023<\/strong>, 14 (3), doi\/10.1128\/mbio.00137-23<\/a><\/p>\n\n\n\n

\n\n\n\n

163. Weig, A. W., O\u2019Conner, P. M., Kwiecinski, J. M., Marciano, O. M., Nunag, A., Gutierrez, A. T., Melander, R. J., Horswill, A. R., and Melander, C. A Structure Activity Relationship Study of 3,4\u2019-Dimethoxyflavone for ArlRS Inhibition in Staphylococcus aureus<\/em>. Organic and Biomolecular Chemistry. <\/em>2023<\/strong>, 21, 3373-3380. doi.org\/10.1039\/<\/a>D3OB00123G<\/a> <\/p>\n\n\n\n

\n\n\n\n

162. Marrujo, S. A., Hubble, V. B., Yang, J., Wang, M., Nemeth, A. M., Barlock, S. L., Juarez, D., Smith, R. D., Melander, R. J., Ernst, R. K., Chang, M., and Melander, C. Dimeric 2-Aminoimidazoles are Highly Active Adjuvants for Gram-positive Selective Antibiotics against Acinetobacter baumannii. European Journal of Medicinal Chemistry. <\/em>2023<\/strong>, 253, 115329. <\/em>doi.org\/10.1016\/j.ejmech.2023.115329<\/a><\/p>\n\n\n\n

\n\n\n\n

161. Onyedibe, K., Nemeth, A. M., Dayal, N., Smith, R., Ernst, R. K., Melander, R. J., Melander, C., and Sintim, H. Re-sensitization of Multidrug Resistant and Colistin Resistant Gram-negative Bacteria to Colistin by Povarov\/Doebner Derived Compounds. ACS Infectious Diseases, <\/em>2023<\/strong>, 9, (2) 283\u2013295. doi.org\/10.1021\/acsinfecdis.2c00417<\/a><\/p>\n\n\n\n

\n\n\n\n

160. Li, H., Mattingly, A. E., Smith, R. D., Melander, R. J., Ernst, <\/sup>R. K., and Melander, C. 6-Bromoindirubin-3\u2019-oxime Derivatives are Highly <\/a>Active Colistin Adjuvants against Klebsiella pneumoniae<\/em>. RSC Medicinal Chemistry<\/em>, 2023<\/strong>,14, 247-252. doi.org\/10.1039\/D2MD00370H<\/a><\/p>\n\n\n\n

\n
\n<\/div><\/div>\n\n\n\n

159. Melander, R. J., Mattingly, A. E., Nemeth, A. M., and Melander, C. Overcoming Intrinsic Resistance in Gram-negative Bacteria using Small Molecule Adjuvants. (Invited Digest) Bioorganic and Medicinal Chemistry Letters, <\/em>2023<\/strong>, 80, 129113. doi.org\/10.1016\/j.bmcl.2022.129113<\/a> <\/p>\n\n\n\n

\n\n\n\n

158. Zeczycki, T. N., Milton, M. E., Jung, D., Thompson, R. J., Jaimes, F. E., Hondros, A. D., Palethorpe, S., Melander, C., and Cavanagh, J. 2-Aminoimidazole Analogs Target PhoP Altering DNA Binding Activity and Affect Outer Membrane Stability in Gram-Negative Bacteria. Biochemistry<\/em>, 2022<\/strong>, 61 (24) 2948\u20132960. doi.org\/10.1021\/acs.biochem.2c00560<\/a><\/a><\/p>\n\n\n\n

\n\n\n\n

157. Young, M., Walsh, D. J., Masters, E., Singh Gondil, V., Laskey, E., Klaczko, M., Awad, H., McGrath, J., Schwarz, E. M., Melander, C. and Dunman, P. M. Identification of Staphylococcus aureus<\/em> Penicillin Binding Protein 4 (PBP4) inhibitors. Antibiotics.<\/em><\/em> 2022<\/strong>, 11(10), 1351. doi.org\/10.3390\/<\/a>antibiotics11101351<\/a><\/p>\n\n\n\n

\n\n\n\n

156. Siwawannapong, K., Nemeth, A. M., Melander, R. J., Rong, J., Davis, J. R., Taniguchi, M., Carpenter, M. E., Lindsey, J. S., and Melander, C. Simple Dipyrrin Analogues of Prodigiosin for use as Colistin Adjuvants, ChemMedChem<\/em>. 2022<\/strong>, 17(6) e202200286doi.org\/10.1002\/cmdc.202200286<\/a><\/p>\n\n\n\n

\n\n\n\n

155. Hoang, K.V., Woolard, K., Yang, C., Melander, C., and Gunn, J.S. Identification of a Host-Targeted Molecule to Control Typhoid Fever. Microbiology Spectrum. Antimicrobial Chemotherapy<\/em>. 2022<\/strong>, 10(3) e00619-22 doi.org\/10.1128\/spectrum.00619-<\/a>22<\/a><\/p>\n\n\n\n

\n\n\n\n

154. Belardinelli, J.M, Li, W., Martin, K.H., Zeiler, M.J., Lian, E., Avanzi, C., Wiersma, C.J., Nguyen, T.V., Angala, B., de Moura, V.C.N., Jones, V., Borlee, B.R., Melander, C., and Jackson, M. 2-Aminoimidazoles Inhibit Mycobacterium abscessus<\/em> Biofilms in a Zinc-Dependent Manner. Int. J. Mol. Sci.<\/em> 2022<\/strong>, 23(6) 2950. doi.org\/10.3390\/ijms23062950<\/a><\/p>\n\n\n\n

\n\n\n\n

153. Zeiler, M. J., Connors, G. M., Durling, G. M., Oliver, A. G., Marquez, M., Melander, R. J., Quave, C. L., and Melander, C. Synthesis, Stereochemical Confirmation, and Derivatization of 12(S<\/em>),16e-Dihydroxycleroda-3,13-dien-15,16-olide, a Clerodane Diterpene That Sensitizes Methicillin-Resistant Staphylococcus aureus<\/em> to \u03b2-Lactam Antibiotics. Angewandte Chemie.<\/em> 2022<\/strong>, 61 (17) e202117458 doi.org\/10.1002\/ange.202117458<\/a><\/p>\n\n\n\n

\n\n\n\n

152. Woolard, K., Sandala, J. L., <\/span>Melander, R. J., Gunn, J. S., and Melander, C. Development Of Small Molecules That Work Cooperatively With Ciprofloxacin To Clear Salmonella Biofilms In A Chronic Gallbladder Carriage Model. European Journal of Medicinal Chemistry<\/em>. 2022<\/strong>, 232, 114203. doi.org\/10.1016\/j.ejmech.2022.114203<\/a><\/p>\n\n\n\n

\n\n\n\n

151. Bailey, J., Gallagher, L. A., Barker, W. T., Hubble, V. B., Gasper, J., Melander, C., and Manoil<\/span>, C. Genetic Dissection of Antibiotic Adjuvant Activity. mBio. <\/em>2022<\/strong>, 13 (1)  e03084-21. doi.org\/10.1128\/mbio.03084-21<\/a><\/p>\n\n\n\n

\n\n\n\n

150. Melander, R. J., Mattingly, A. E., and Melander, C. Phenotypic Screening of Compound Libraries as a Platform for the Identification of Antibiotic Adjuvants \u2013 Identification of Colistin Adjuvants from a Natural Product Library. Methods in Enzymology. <\/em>2022<\/strong>, 665, 53-176. doi.org\/10.1016\/bs.mie.2021.11.005<\/a><\/p>\n\n\n\n

\n\n\n\n

149. Li, H., Mattingly, A. E., Jania, L. A., Smith, R., Melander, R. J., Ernst, R. K., Koller, B. H., and Melander, C. Benzimidazole Isosteres of Salicylanilides are Highly Active Colistin Adjuvants. ACS Infectious Diseases. <\/em>2021<\/span><\/strong>, <\/span><\/em>7<\/span> <\/span><\/em>(12)<\/span> <\/span>3303\u20133313. <\/span>doi.org\/10.1021\/acsinfecdis.1c00463<\/a><\/p>\n\n\n\n

\n\n\n\n

148. Borrel, A., Melander, C., and Fourches, D. Chemoinformatics Analysis of
Fluoroquinolones and Their Inhibition Potency Against Four Pathogens. Molecular Informatics. <\/em>2021<\/strong>, 40 (5) 2000215. doi.org\/10.1002\/minf.202000215<\/a><\/p>\n\n\n\n

\n\n\n\n

147. Weig, A. W., Barlock, S. L., O’Connor, P. M.,  Marciano, O. M., Melander, R. J., and Melander, C. A Scaffold Hopping Strategy to Generate New Aryl-2-Amino Pyrimidine MRSA Biofilm Inhibitors. RSC Medicinal Chemistry. <\/span><\/span><\/em>2021<\/strong>, <\/span><\/span>12<\/span><\/span>, 293-296.<\/span><\/span> doi.org\/10.1039\/D0MD00<\/span><\/span>238K<\/span><\/span><\/a><\/p>\n\n\n\n

\n\n\n\n

146. Sandala, J. L, Eichar, B. W., Kuo, L. G., Hahn, M. M., Basak, A. K.,  Huggins, W. M., Woolard, K., Melander, C., and  Gunn, J. S. A Dual-therapy Approach for the Treatment of Biofilm-mediated Salmonella <\/em>Gallbladder Carriage. PLOS Pathogens, <\/em>2020<\/strong>, 16 (12): e1009192. doi.org\/10.1371\/journal.ppat.1009192<\/a><\/p>\n\n\n\n

\n\n\n\n

145. Barker, W. T., Jania, L. A., Melander, R. J.,  Koller, B. H., and Melander, C. Eukaryotic Phosphatase Inhibitors Enhance Colistin Efficacy in Gram-negative Bacteria. Chemical Biology & Drug Design. <\/em>2020<\/strong>, 96 (5) 1180-1186. doi.org\/10.1111\/cbdd.13735<\/a><\/p>\n\n\n\n

\n\n\n\n

144. Melander, R. J., Basak, A. K., and Melander, C. Natural Products as Inspiration for the Development of Bacterial Antibiofilm Agents. Natural Product Reports. <\/em>2020<\/strong>, 37, 1454 – 1477. doi.org\/10.1039\/D0NP00022A<\/a><\/p>\n\n\n\n

\n\n\n\n

143. Mattingly, A. E.,  Cox, K. E., Smith, R., Melander, R. J., Ernst,  R. K., and Melander, C. Screening an Established Natural Product Library Identifies Secondary Metabolites that Potentiate Conventional Antibiotics. ACS Infectious Diseases. <\/em>2020<\/span><\/strong>, <\/span><\/em>6<\/span> (<\/span>10)<\/span> <\/span><\/em>2629\u20132640.<\/span> doi.org\/10.1021\/acsinfecdis.0c00259<\/a><\/p>\n\n\n\n

\n\n\n\n

142. Rasapalli, S., <\/span><\/span>Murphy, Z. F., <\/span><\/span>Sammeta, V., <\/span><\/span>Golen, J. A., <\/span><\/span>Weig, A. W., <\/span><\/span>Melander, R. J., <\/span><\/span>Melander, C., <\/span><\/span>Macha, P., <\/span><\/span>Vasudev, M., C. <\/span><\/span>Synthesis and Biofilm Inhibition Studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H<\/em>)-ones. <\/span>Bioorganic & Medicinal Chemistry Letters. <\/span><\/em>2020<\/span><\/strong>, <\/span><\/em>30 (23)<\/span> <\/span><\/em>127550.<\/span> doi.org\/10.1016\/j.bmcl.2020.127550<\/a><\/p>\n\n\n\n

\n\n\n\n

141. Hubble, V. B, Bartholomew, K., Weig, A. W., Brackett, S. M., Barlock, S. L., Mattingly, A. E., Nemeth, A. M., Melander, R. J., and Melander, C. Augmenting the Activity of Macrolide Adjuvants Against Acinetobacter baumannii.<\/em> ACS Medicinal Chemistry Letters, <\/i><\/span><\/em>2020<\/span><\/strong>, 11 (<\/span>9)<\/span> 1723\u2013173<\/span>1. <\/span>doi.org\/10.1021\/acsmedchemlett.0c00276<\/a><\/p>\n\n\n\n

\n\n\n\n

140. Zeiler, M. J., Melander, R. J.,  and Melander, C. Second Generation Meridianin Analogs Inhibit the Formation of Mycobacterium smegmatis Biofilms<\/em> and Sensitize Polymyxin-Resistant Gram-Negative Bacteria to Colistin. ChemMedChem. <\/em>2020<\/strong> 15<\/span>, (17) <\/span>1672-167 doi.org\/10.1002\/cmdc.202000438<\/a><\/p>\n\n\n\n

\n\n\n\n

139. Dettweiler, M., Melander, R. J., Porras, G., Risener, C., Marquez, L., Samarakoon, T., Melander, C., and Quave, C. L. A Clerodane Diterpene from Callicarpa americana<\/em> Resensitizes Methicillin-Resistant Staphylococcus aureus<\/em> to \u00df-Lactam Antibiotics. ACS Infectious Diseases. <\/em>2020<\/span><\/strong>, <\/span><\/em>6 (<\/span>7) <\/span>1667\u20131673 <\/span>doi.org\/10.1021\/acsinfecdis.0c00307<\/a><\/p>\n\n\n\n

\n\n\n\n

138. Brackett, S. M.,  Cox, K. E.,  Barlock, S. L.,  Huggins, W. M.,  Ackart, D. F.,  Bassaraba, R. J.,  Melander, R. J., and Melander, C. Meridianin D Analogues Possess Antibiofilm Activity Against Mycobacterium smegmatis. RSC Medicinal Chemistry. <\/em>2020<\/strong>, 11, 92-97 doi.org\/10.1039\/C9MD00466A<\/a><\/p>\n\n\n\n

\n\n\n\n

137. Nemeth, A. M., Basak, A. K., Weig, A. W., Marrujo, S. A., Barker, W. T., Jania, L. A., Hendricks, T. A., Sullivan, A. E., O\u2019Connor, P. M., Melander, R. J., Koller, B. H., and Melander. C. Structure Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants. ChemMedChem. <\/em>2020<\/strong>, 15 (2) 210-218 doi.org\/10.1002\/cmdc.201900560<\/a><\/p>\n\n\n\n

\n\n\n\n

136. Yan, A., Huang, M., Melander, C., Kjellerup, B. Dispersal and Inhibition of Biofilms Associated with Infections.  Journal of Applied Microbiology. <\/em>2020<\/strong>, 128 (5) 1279-1288. doi.org\/10.1111\/jam.14491<\/a><\/p>\n\n\n\n

\n\n\n\n

135. Melander R.J., Melander C. Strategies for the Eradication of Biofilm-Based Bacterial Infections. Antibacterial Drug Discovery to Combat MDR. (Springer)<\/em> 2019<\/strong>, 499-526 doi.org\/10.1007\/978-981-13-9871-1_22<\/a><\/p>\n\n\n\n

\n\n\n\n

134. Barker, W. T., Nemeth, A. M., Brackett, S. M., Basak, A. K., Chandler, C. E., Jania, L. A., Zuercher, W. J., Melander, R. J., Koller, B. H., Ernst, R. K. and Melander, C. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-negative Bacteria. ACS Infectious Diseases, <\/em>2019<\/span><\/strong>, <\/span><\/em>5<\/span>, <\/span><\/em>(10), <\/span>1764-1771 <\/span>doi.org\/10.1021\/acsinfecdis.9b00212<\/a><\/p>\n\n\n\n

\n\n\n\n

133. Cox, K.E., and Melander, C. Antibiofilm Activity of Quinazoline Derivatives against Mycobacterium smegmatis. MedChemComm, <\/em>2019, <\/strong>10, 1177-1179 doi.org\/10.1039\/C9MD00156E<\/a><\/p>\n\n\n\n

\n\n\n\n

132. Martin, S.E., Melander, R.J., Brackett, C.M., Scott, A.J., Chandler, C.E., Nguyen, C.M., Minrovic, B.M., Harrill, S.E., Ernst. R.K., Manoil, C., and Melander, C. Small Molecule Potentiation of Gram-positive Selective Antibiotics Against Acinetobacter baumannii<\/em>. ACS Infectious Diseases, <\/em>2019<\/strong>, 5, (7), 1223-1230 doi.org\/10.1021\/acsinfecdis.9b00067<\/a><\/p>\n\n\n\n

\n\n\n\n

131. Minrovic, B.M., Hubble, V.B., Barker, W.T., Jania, L.A., Melander, R.J., Koller, B.H., and Melander, C. Second Generation Tryptamine Derivatives Potently Sensitize Colistin-Resistant Bacteria to Colistin. ACS Medicinal Chemistry Letters, <\/em>2019<\/strong>, <\/em>10 (5), 828-833. doi.org\/10.1021\/acsmedchemlett.9b00135<\/a><\/p>\n\n\n\n

\n\n\n\n

130. Barker, W.T., Chandler, C.E., Melander, R.J., Ernst, R.K., and Melander, C. Tryptamine Derivatives Disarm Colistin Resistance in Polymyxin-Resistant Gram-negative Bacteria. Bioorganic and Medicinal Chemistry, <\/em>2019<\/strong>, 27 (9), 1776-1788. doi.org\/10.1016\/j.bmc.2019.03.019<\/a><\/p>\n\n\n\n

\n\n\n\n

129. Nguyen, T.V., Minrovic, B.M., Melander, R.J., and Melander, C. Identification of Anti\u2010Mycobacterial Biofilm Agents Based on the 2\u2010Aminoimidazole Scaffold, ChemMedChem, <\/em>2019<\/strong>, 14 (9) 927-937. doi.org\/10.1002\/cmdc.201900033<\/a><\/p>\n\n\n\n

\n\n\n\n

128. Nguyen, T.V., Peszko, M.T., Melander, R.J., and Melander, C. Using 2-Aminobenzimidazole Derivatives to Inhibit Mycobacterium smegmatis <\/em>Biofilm Formation, Med. Chem. Commun.<\/i>, 2019<\/strong>,10, 456-459. doi.org\/10.1039\/C9MD00025A<\/a><\/p>\n\n\n\n

\n\n\n\n

127. Hubble, V.B., Hubbard, B., Minrovic, B.M., Melander, R.J., and Melander, C. Using Small Molecule Adjuvants to Repurpose Azithromycin for Use Against Pseudomonas aeruginosa<\/em>. ACS Infectious Diseases, <\/em>2019<\/strong>, <\/em>5 (1), 141-151. doi.org\/10.1021\/acsinfecdis.8b00288<\/a><\/p>\n\n\n\n

\n\n\n\n

126. Jeon, A.B., Ackart, D.F., Li, W., Jackson, M., Melander, R.J., Melander, C., Abramovitch, R.B., Chicco, A.J., Basaraba, R.J., Obregon-Henao, A. 2-Aminoimidazoles Collapse Mycobacterial Proton Motive Force and Block the Electron Transport Chain, Scientific Reports<\/em>, 2019<\/strong>, 9 <\/em>(1), <\/em>1513. <\/em>doi.org\/10.1038\/s41598-018-38064-7<\/a><\/p>\n\n\n\n

\n\n\n\n

125. Huggins, W.M., Nguyen, T.V., Hahn, N.A., Baker, J.T., Kuo, L.G., Kaur, D., Melander, R.J., Gunn, J.S., and Melander, C. 2-Aminobenzimidazoles as Antibiofilm Agents Against Salmonella eterica <\/em>Serovar Typhimurium. MedChemComm, <\/em>2018<\/strong>, 9 <\/em>(9), <\/em>1547-1522. doi.org\/10.1039\/c8md00298c<\/a><\/p>\n\n\n\n

\n\n\n\n

124. Minrovic, B.M., Jung, D., Melander, R.J., and Melander, C. A New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumanii<\/em>. ACS Infectious Diseases, <\/em>2018<\/strong>, 4 <\/em>(9), <\/em>1368-1376. <\/em>doi.org\/10.1021\/acsinfecdis.8b00103<\/a><\/p>\n\n\n\n

\n\n\n\n

123. Huggins, W.M., Barker, W.T., Baker, J.T., Hahn, N., Melander, R.J., and Melander, C. Meridianin D Analogues Display Antibiofilm Activity Against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria. ACS Medicinal Chemistry Letters, <\/em>2018<\/strong>, 9 <\/em>(7), <\/em>702-707 doi.org\/10.1021\/acsmedchemlett.8b00161<\/a><\/p>\n\n\n\n

\n\n\n\n

122. Martin, S.E., Nguyen, C.M., Basaraba, R.J., and Melander, C. Analogue Synthesis Reveals Decoupling of Antibiofilm and \u00df-Lactam Potentiation Activities of a Lead 2-Aminoimidazole Adjuvant Against Mycobacterium smegmatis. Chemical Biology & Drug Design, <\/em>2018<\/strong>, 92 <\/em>(3), <\/em>1403-1408. <\/em>doi.org\/10.1111\/cbdd.13208<\/a><\/p>\n\n\n\n

\n\n\n\n

121. Milton, M.E., Minrovic, B.M., Harris, D., Kang, B., Jung, D., Lewis, C.P., Thompson, R.J., Melander, R. J., Zeng, D., Melander, C., and Cavanagh, J. Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii<\/em> and QseB from Francisella <\/em>spp. Frontiers<\/em>, 2018<\/strong>, 5<\/em>, Article 15. doi.org\/10.3389\/fmolb.2018.00015<\/a><\/p>\n\n\n\n

\n\n\n\n

120. Melander, R.J., Zurawski, D.V., and Melander, C. Narrow-Spectrum Antibacterial Agents. (Invited review). MedChemComm, <\/em>2018<\/strong>, 9, <\/em>12-21. <\/em>doi.org\/10.1039\/C7MD00528H<\/a><\/p>\n\n\n\n

\n\n\n\n

119. Robb, A.J., Vinogradov, S., Anderson, E., Blackledge, M.S. Melander, C., and Hvastkovs, E.G. Electrochemical Detection of Small Molecule Induced Biofilm Dispersion. Electrochemica Acta, <\/em>2018<\/strong>, 268, <\/em>276-282.<\/em> doi.org\/10.1016\/j.electacta.2018.02.113<\/a><\/p>\n\n\n\n

\n\n\n\n

118. Barker, W. T., Martin, S.E., Chandler, C.E., Nguyen, T.V., Harris, T.L., Goodell, C., Melander, R.J., Doi, Y., Ernst, R. K., Melander, C. Small Molecule Adjuvants that Suppress Both Chromosomal and mcr-1 <\/em>Encoded Colistin-Resistance and Amplify Colistin Efficacy in Polymyxin-Susceptible Bacteria. Bioorganic and Medicinal Chemistry, <\/em>2017<\/strong>, 25, <\/em>5749-5753. doi.org\/10.1016\/j.bmc.2017.08.055<\/a><\/p>\n\n\n\n

\n\n\n\n

117. Milton, M.E., Allen, C.L., Feldmann, E.A., Bobay, B.G., Stephens, M.D., Melander, R.J., Theisen, K.E., Zeng, D., Thopmson, R.J., Melander, C.<\/strong>, Cavanagh, J. Structure of the Francisella Response Regulator QseB Receiver Domain, and Characterization of QseB Inhibition by Antibiofilm 2-Aminoimidazole-Based Compounds. Molecular Microbiology, <\/em>2017<\/strong>, 106, <\/em>223-235.  doi.org\/10.1111\/mmi.13759<\/a><\/p>\n\n\n\n

\n\n\n\n

116. Jeon, A.B., Obregon-Henao, A., Ackart, D.F., Podell, B.K., Belardinelli, J., Jackson, M., Nguyen, T.V., Blackledge, M.S., Melander, R.J., Melander, C., Johnson, B., Abramovitch, R., and Basaraba, R.J. 2-Aminoimidazoles Potentiate \u00df-Lactam Antimicrobial Activity against Mycobacterium tuberculosis<\/em> by Reducing \u00df-Lactamase Secretion and Increasing Cell Wall Permeability. PLOS One<\/em>, 2017<\/strong>, 12, <\/em>e0180925. <\/em>doi.org\/10.1371\/journal.pone.0180925<\/a><\/p>\n\n\n\n

\n\n\n\n

115. Byrne-Nash, R., Lucero, D.M., Osbaugh, N.A., Melander, R.J., Melander, C., and Feldheim, D.L. Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered Through Small Molecule Variable Ligand Display. Bioconjugate Chemistry,<\/em> 2017<\/strong>, 28, <\/em>1807-1810. <\/em>doi.org\/10.1021\/acs.bioconjchem.7b00199<\/a><\/p>\n\n\n\n

\n\n\n\n

114. Melander, R.J. and Melander, C.<\/strong> The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach. ACS Infectious Diseases<\/em>, 2017<\/strong>, 3, <\/em>559-563. <\/em>doi.org\/10.1021\/acsinfecdis.7b00071<\/a><\/p>\n\n\n\n

\n\n\n\n

113. Garcia, S.S., Blackledge, M.S., Michalek, S., Su, L., Ptacek, T., Eipers, P., Morrow, C., Lefkowitz, E.J., Melander, C., and Wu, H. Selective Targeting of Streptococcus mutans<\/em> by a Novel Small Molecule Preserves the Oral Microbiome in vivo<\/em>. Journal of Dental Research<\/em>, 2017<\/strong>, 96, <\/em>807-814. <\/em>doi.org\/10.1177\/0022034517698096<\/a><\/p>\n\n\n\n

\n\n\n\n

112. Melander, R.J., and Melander, C. Antibiotic Adjuvants. Topics in Medicinal Chemistry: Antibacterials (Springer)<\/em>. 2017<\/strong>, 25, 89-118. doi.org\/10.1007\/7355_2017_10<\/a><\/p>\n\n\n\n

\n\n\n\n

111. Nguyen, T.V., Blackledge, M.S., Lindsey, E.A., Minrovic, B.M., Ackart, D.F., Jeon, A.B., Obregon-Henao, A., Melander, R.J., Basaraba, R.J., and Melander, C. The Discovery of 2-Aminobenzimidazoles that Sensitize M. smegmatis <\/em>and M. tuberculosis <\/em>to \u00df-Lactam Antibiotics in a Pattern Distinct from \u00df-Lactamase Inhibitors. Angewandte Chemie, <\/em>2017<\/strong>, 56<\/em> (14), 3940-3944. <\/em>doi.org\/10.1002\/anie.201612006<\/a><\/p>\n\n\n\n

\n\n\n\n

110. Draughn, C. L., Allen, C.L., Routh, P.A., Stone, M.R., Kirker, K.R., Schuchman, R.M., Linder, K.E., Baynes, R.E., Garth, J., Melander, C.<\/strong>, Pollard, A., and Cavanagh, J. Evaluation of a 2-Aminoimidazole Variant as Adjuvant Treatment for Dermal Bacterial Infections. Drug Design, Development, and Therapy<\/em>. 2017<\/strong>, 11, <\/em>153-162. <\/em>doi.org\/10.2147\/DDDT.S111865<\/a><\/p>\n\n\n\n

\n\n\n\n

109. Huggins. W.M., Minrovic, B.M., Corey, B.W., Jacobs, A.C., Melander, R.J., Zurawski, D.V., and Melander, C. 1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics Against Multi-Drug Resistant Acinetobacter baumannii<\/em>. ACS Medicinal Chemistry Letters, <\/em>2017<\/strong>, 8 <\/em>(1), 27-31. <\/em>doi.org\/10.1021\/acsmedchemlett.6b00296 <\/a><\/p>\n\n\n\n

\n\n\n\n

108. Corey, W., Thompson, M.G., Hittle, L.E., Jacobs, A.C., Asafo-Adjei, E.A., Dunn, T.M., Huggins, W.M., Melander, R.J., Melander, C.<\/strong>, Ernst, R.K., and Zurawski, D.V. 1,2,4-Triazolidine-3-thiones Have Specific Activity Against Acinetobacter baumannii <\/em>Amongst Common Nosocomial Pathogens. ACS Infectious Diseases<\/em>, 2017<\/strong>, 3 <\/em>(1), 62-71. <\/em>doi.org\/10.1021\/acsinfecdis.6b00133<\/a><\/p>\n\n\n\n

\n\n\n\n

107. Melander, R.J. and Melander, C. Inhibitors of Biofilm Production. Antibiotic Drug Discovery: New Targets and Molecular Entities<\/i> (The Royal Society of Chemistry).<\/em> 2017<\/strong>, 43-75. doi.org\/10.1039\/9781782629870-00043<\/a><\/p>\n\n\n\n

\n\n\n\n

106. Stephens, M.D., Yodsanit, N., and Melander, C. <\/strong>Potentiation of the Fosmidomycin Analogue FR 900098 with Substituted 2-Oxazolines Against Francisella novicida. MedChemComm. <\/em>2016<\/strong>, 7, 1952-1956. <\/em>doi.org\/10.1039\/C6MD00365F<\/a><\/p>\n\n\n\n

\n\n\n\n

105. Melander, R.J., Liu, H.-B., Stephens, M.D., Bewley, C.A., and Melander, C. Marine Sponge Alkaloids as a Source of Anti-Bacterial Adjuvants. Bioorganic and Medicinal Chemistry Letters, <\/em>2016<\/strong>, 26 <\/em>(24), 5863-5866. <\/em>doi.org\/10.1016\/j.bmcl.2016.11.018<\/a><\/p>\n\n\n\n

\n\n\n\n

104. Stephens, M.D., Yodsanit, N., and Melander, C. <\/strong>Analogues of the Natural Product Ethyl N-(2-Phenethyl) Carbamate as Potent Biofilm Inhibitors of Methicillin Resistant Staphylococcus aureus<\/em>. Organic and Biomolecular Chemistry<\/em>. 2016<\/strong>, 14, 6853 – 6856. <\/em>doi.org\/10.1039\/c6ob00706f<\/a><\/p>\n\n\n\n

\n\n\n\n

103. Stephens, M.D., Hubble, V.B., Ernst, R.K., Melander, R.J., Cavanagh, J., and Melander, C.<\/strong> Potentiation of Francisella<\/em> Resistance to Conventional Antibiotics through Small Molecule Adjuvants. MedChemComm <\/em>(Special Issue on Antibiotic Resistance). 2016<\/strong>, 7 <\/em>(1), 128-131. <\/em>doi.org\/10.1039\/C5MD00353A<\/a><\/p>\n\n\n\n

\n\n\n\n

102. Brackett, C.M., Furlani, R.E., Anderson, R.G., Krishnamurthy, A., Melander, R.J., Moskowitz, S.M., Ernst, R.K. and Melander, C.<\/strong> Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity. Tetrahedron <\/em>(Special Issue on Antibiotic Resistance), 2016<\/strong>, 72 <\/em>(25), 128-131. <\/em>doi.org\/10.1016\/j.tet.2015.09.019<\/a><\/p>\n\n\n\n

\n\n\n\n

101. Pan, W., Fan, W., Wu, H., Melander, C., and Liu, C. A New Small Molecule Inhibits Streptococcus mutans<\/em> Biofilms in vitro<\/em> and in vivo<\/em>. Journal of Applied Microbiology. <\/em>2015<\/strong>, 119 <\/em>(5), 3406-3409. <\/em>doi.org\/10.1111\/jam.12940<\/a><\/p>\n\n\n\n

\n\n\n\n

100. Furlani, R.E., Richardson, M.A., Podell, B.K., Ackart, D.F., Haugen, J.D., Melander, J.J., Basaraba, R.J., and Melander, C. Second Generation 2-Aminoimidazole Based Advanced Glycation End Product Inhibitors and Breakers. Bioorganic and Medicinal Chemistry Letters (25th anniversary). <\/em>2015<\/strong>, 25 <\/em>(21), 4820-4823. doi.org\/10.1016\/j.bmcl.2015.06.080<\/a><\/p>\n\n\n\n

\n\n\n\n

99. Garrido, C., Simpson, C.A., Dahl, N.P., Bresee, J., Whitehead, D.C., Lindsey, E.A., Harris, T.L., Smith, C.A., Carter, C.J., Feldheim, D.L., Melander, C, and Margolis, D.M. Gold Nanoparticles to Improve HIV Drug Delivery. Future Medicinal Chemistry, <\/em>2015<\/strong>, 7 <\/em>(9), 1097-1107. doi.org\/10.4155\/fmc.15.57<\/a><\/p>\n\n\n\n

\n\n\n\n

98. Richardson, M.A., Furlani, R.E., Podell, B.K., Ackart, D.F., Haugen, J.D., Melander, R.J., Melander, C., <\/strong>and Basaraba, R.J. Inhibition and Breaking of Advanced Glycation End-Products with Bis-2-Aminoimidazole Derivatives. Tetrahedron Letters, <\/em>2015<\/strong>, 56 <\/em>(23), 3406-3409. doi.org\/10.1016\/j.tetlet.2015.01.122<\/a><\/p>\n\n\n\n

\n\n\n\n

97. Melander, R.J., and Melander, C. From Worms to Targeting Virulence Factors (Invited Commentary). Chemistry and Biology, <\/em>2015<\/strong>, 22<\/em> (4), 436-437. doi.org\/10.1016\/j.chembiol.2015.04.005<\/a><\/p>\n\n\n\n

\n\n\n\n

96. Stowe, S.D., Thompson, R.J., Peng, L., Su, Z., Blackledge, M.S., Draughn G.L., Coe, W.H., Johannes, E., Lapham, V.K., Mackenzie, J., Melander, C., and Cavanagh, J. Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Gram-Negative Pathogen, Acinetobacter baumannii<\/em>. Current Drug Delivery, <\/em>2015<\/strong>, 12<\/em> (2), 223-30. <\/em>doi.org\/10.2174\/1567201811666140924125740<\/a><\/p>\n\n\n\n

\n\n\n\n

95. Wahome, P.G., Beauchesne, K.R., Cato-Pedone, A., Cavanagh, C., Melander, C., Zimba, P., and Moeller, P.D.R. Augmenting Anti-Cancer Natural Products with a Small Molecule Adjuvant. Marine Drugs, <\/em>2015<\/strong>, 13<\/em> (1), 65-75. <\/em>doi.org\/10.3390\/md13010065<\/a><\/p>\n\n\n\n

\n\n\n\n

94. Melander, R.J. and Melander, C. Innovative Strategies for Combating Biofilm-based Infections Biofilm-based Healthcare-associated Infections (Springer)<\/em>. 2015<\/strong>, 831, 69-91. doi.org\/10.1007\/978-3-319-09782-4_6<\/a><\/p>\n\n\n\n

\n\n\n\n

93. Gifford, J.C., Bresee, J., Carter, C.J., Wang, G., Melander, R., Melander, C., and Feldheim, D.L. Thiol-Modified Gold Nanoparticles for the Inhibition of M. smegmatis<\/em>. Chemical Communications, <\/em>2014<\/strong>, 50<\/em> (100), 15860-15863. doi.org\/10.1039\/c4cc06236a<\/a><\/p>\n\n\n\n

\n\n\n\n

92. Brackett, C.M., Melander, R.J., An, I.H., Krisnamurthy, A., Thompson, R.J., Cavanagh, J., and Melander, C. Small Molecule Suppression of \u00df-Lactam Resistance in Multi-drug Resistant Gram-negative Pathogens. Journal of Medicinal Chemistry, <\/em>2014<\/strong>, 57<\/em> (17), 7450-7458. <\/em>doi.org\/10.1021\/jm501050e<\/a><\/p>\n\n\n\n

\n\n\n\n

91. Wright, C.J., Wu, H., Melander, R.J., Melander, C, and Lamont, R.J. Disruption of Heterotypic Community Development by Porphyromonas gingivalis<\/em> with Small Molecule Inhibitors. Molecular Oral Microbiology, <\/em>2014<\/strong>, 29<\/em> (5), 185-193. <\/em>doi.org\/10.1111\/omi.12060<\/a><\/p>\n\n\n\n

\n\n\n\n

90. Melander, R.J., Minvielle, M.J., and Melander, C. Controlling Bacterial Behavior with Indole-containing Natural Products and Derivatives (invited review). Tetrahedron<\/em>, 2014<\/strong>, 70 <\/em>(37), 6363-6372. <\/em>doi.org\/10.1016\/j.tet.2014.05.089<\/a><\/p>\n\n\n\n

\n\n\n\n

89. Bresee, J., Bond, C.M., Worthington, R.J., Smith, C.A., Carter, C.J., Simpson, C.A., Wang, G., Hartman, J., Osbaugh, N.A., Melander, C., and Feldheim, D.L. Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics. Journal of the American Chemical Society, <\/em>2014<\/strong>, 136<\/em> (14), 5295-5300. <\/em>doi.org\/10.1021\/ja408505n<\/a><\/p>\n\n\n\n

\n\n\n\n

88. Ackart, D.F., Lindsey, E.A., Podell, B.K., Melander, R.J., Basaraba, R.J., and Melander, C. <\/em>Reversal of Mycobacterium tuberculosis<\/em> Phenotypic Drug Resistance by 2-Aminoimidazole Based Small Molecules. FEMS Pathogens and Disease, <\/em>2014<\/strong>, 70<\/em> (3), 370-378. <\/em>doi.org\/10.1111\/2049-632X.12143<\/a><\/p>\n\n\n\n

\n\n\n\n

87. Ackart, D.F., Parks, Q.M., Kirk, N.M., Podell, B.K., Melander, C., Orme, I.M., Leid, J.G., Nick, J.A., and Basaraba, R.J. Expression of Antimicrobial Drug Tolerance by Attached Communities of Mycobacterium tuberculosis. FEMS Pathogens and Disease, <\/em>2014<\/strong>, 70<\/em> (3), 359-369. <\/em>doi.org\/10.1111\/2049-632X.12144<\/a><\/p>\n\n\n\n

\n\n\n\n

86. Worthington, R.J, Richards, J.J., and Melander, C. Non-Microbicidal Control of Bacterial Biofilms with Small Molecules. Anti-Infective Agents<\/em>, 2014<\/strong>, 12 <\/em>(1), 120-38. doi.org\/10.2174\/22113525113119990107<\/a><\/p>\n\n\n\n

\n\n\n\n

85. Harris, T.L., Worthington, R.J., Hittle, L.E., Zurawski, D.V., Ernst, R.K., and Melander, C. <\/strong>Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance. ACS Chemical Biology, <\/em>2014<\/strong>, 9 <\/em>(1), 127-7. <\/em>doi.org\/10.1021\/cb400490k<\/a><\/p>\n\n\n\n

\n\n\n\n

84. Minvielle, M.J., Eguren, K., and Melander, C. Highly Active Modulators of Indole Signaling to Alter Pathogenic Behavior in Gram-Negative and Gram-Positive Bacteria. Chemistry: A European Journal, <\/em>2013<\/strong>, 19 <\/em>(51), 17595-602. <\/em>doi.org\/10.1002\/chem.201303510<\/a><\/p>\n\n\n\n

\n\n\n\n

83. Blackledge, M.S., Worthington, R.J., and Melander, C. Biologically-Inspired Strategies for Combating Bacterial Biofilms. Current Opinion in Pharmacology<\/em>, 2013<\/strong>, 13 <\/em>(5), 699-706. doi.org\/10.1016\/j.coph.2013.07.004<\/a><\/p>\n\n\n\n

\n\n\n\n

82. Minvielle, M.J., Bunders, C.A., and Melander, C. Indole\/triazole Conjugates are Selective Inhibitors and Inducers of Bacterial Biofilms. MedChemComm, <\/em>2013<\/strong>, 4 <\/em>(6), 916-919. <\/em>doi.org\/10.1039\/C3MD00064H<\/a><\/p>\n\n\n\n

\n\n\n\n

81. Worthington, R.J. and Melander, C. Overcoming Resistance to \u03b2-Lactam Antibiotics (JOCSynopsis). Journal of Organic Chemistry, <\/em>2013<\/strong>, 78 <\/em>(9), 4207-4213. <\/em>doi.org\/10.1021\/jo400236f<\/a><\/p>\n\n\n\n

\n\n\n\n

80. Blackledge, M.S. and Melander, C. Programmable DNA-binding Small Molecules. Bioorganic and Medicinal Chemistry, <\/em>2013<\/strong>, 21 <\/em>(20), 6101-14. <\/em>doi.org\/10.1016\/j.bmc.2013.04.023<\/a><\/p>\n\n\n\n

\n\n\n\n

79. Worthington, R.J., Blackledge, M.S., and Melander, C. Small Molecule Inhibition of Bacterial Two-Component Systems to Combat Antibiotic Resistance and Virulence. Future Medicinal Chemistry, <\/em>2013<\/strong>, 5 <\/em>(11), 1265-1284. <\/em>doi.org\/10.4155\/fmc.13.58<\/a><\/p>\n\n\n\n

\n\n\n\n

78. Worthington, R.J. and Melander, C. Combination Approaches to Combat Multi-Drug Resistant Bacteria. Trends in Biotechnology<\/em>, 2013<\/strong>, 31 <\/em>(3), 177-184. doi.org\/10.1016\/j.tibtech.2012.12.006<\/a><\/p>\n\n\n\n

\n\n\n\n

77. Furlani, R., Yeagley, A.A., and Melander, C. A Flexible Approach to 1,4-Disubstituted 2-Aminoimidazoles that Inhibit and Disperse Biofilms and Potetiate the Effects of \u03b2-Lactams against Multi-Drug Resistant Bacteria. European Journal of Medicinal Chemistry<\/em>, 2013<\/strong>, 62<\/em>, 59-70. <\/em>doi.org\/10.1016\/j.ejmech.2012.12.005<\/a><\/p>\n\n\n\n

\n\n\n\n

76. Yeagley, A.A., Su, Z., McCullough, K., Worthington, R. J., and Melander, C. N-Substituted 2-Aminoimidazole Inhibitors of MRSA Biofilm Formation Accessed Through Direct 1,3-Bis(tert-<\/em>butoxycarbonyl)guanidine Cyclization. Organic and Biomolecular Chemistry,<\/em> 2013<\/strong>, 11<\/em> (1), 130-137. <\/em>doi.org\/10.1039\/C2OB26469B<\/a><\/p>\n\n\n\n

\n\n\n\n

75. Thompson, R.J., Bobay, B.G., Stowe, S.D., Peng, L. Su, Z., Actis, L.A., Melander, C., and Cavanagh, J. Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Anti-Biofilm Agent. Biochemistry<\/em>, 2012<\/strong>, 51 <\/em>(49), 9776-9778. <\/em>doi.org\/10.1021\/bi3015289<\/a><\/p>\n\n\n\n

\n\n\n\n

74. Harris, T.L., Worthington, R.J., and Melander, C. Potent Small Molecule Suppression of Oxacillin Resistance in methicillin-resistant Staphylococcus aureus<\/em>. Angewandte Chemie, <\/em>2012<\/strong>, 51<\/em> (45), 11254-11257. <\/em>doi.org\/10.1002\/anie.201206911<\/a><\/p>\n\n\n\n

\n\n\n\n

73. Lindsey, E.A., Brackett, C.M., Mullikin, T., Alcaraz, C., and Melander, C. The Discovery of N-1 Substituted 2-Aminobenzimidazoles as Zinc-Dependent S. aureus<\/em> Biofilm Inhibitors. MedChemComm<\/em>, 2012<\/strong>, 3<\/em> (11), 1462-1465. doi.org\/10.1039\/C2MD20244A<\/a><\/p>\n\n\n\n

\n\n\n\n

72. Su, Z., Yeagley, A.A., Su, R., Peng, L., and Melander, C. Structural Studies on 4,5-Disubstituted-2-Aminoimidazole-Based Biofilm Modulators that Suppress Bacterial Resistance to \u03b2-Lactams. ChemMedChem<\/em>, 2012<\/strong>, 7<\/em> (11), 2030-2039. <\/em>doi.org\/10.1002\/cmdc.201200350<\/a><\/p>\n\n\n\n

\n\n\n\n

71. Melander, C and Margolis, D.M. Forcing an Enemy into the Open. Nature Chemistry, <\/em>2012<\/strong>, 4 (9), 692-693. doi.org\/10.1038\/nchem.1444<\/a><\/p>\n\n\n\n

\n\n\n\n

70. Olson, A.L., Thompson, R.J., Melander, C., and Cavanagh, J. Chemical Shift Assignments and Secondary Structure Prediction of the C-Terminal Domain of the Response Regulator BfmR from Acinetobacter baumannii. Journal of Biomolecular NMR, <\/em>2012<\/strong>, 6 <\/em>(1), 95-8. <\/em>doi.org\/10.1007\/s12104-012-9454-2<\/a><\/p>\n\n\n\n

\n\n\n\n

69. Worthington, R.J. and Melander, C. Deconvoluting Interspecies Bacterial Communication. Angewandte Chemie<\/em>, 2012<\/strong>, 51<\/em> (26), 6314-6315. doi.org\/10.1002\/anie.201202440<\/a><\/p>\n\n\n\n

\n\n\n\n

68. Worthington, R.J., Richards, J.J., and Melander, C. Small Molecule Control of Bacterial Biofilms, Organic and Biomolecular Chemistry<\/em>, 2012<\/strong>, 10<\/em> (37), 7457 – 7474. <\/em>doi.org\/10.1039\/c2ob25835h<\/a><\/p>\n\n\n\n

\n\n\n\n

67. Worthington, R.J., Rogers, S.A., Huigens, R.W., Melander, C., and Ritchie, D.F. Foliar Applied Small Molecule That Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria<\/em> on Peppers. Plant Disease<\/em>, 2012 <\/strong>96<\/em> (11), 1638-1644.<\/em> doi.org\/10.1094\/PDIS-02-12-0190-RE<\/a><\/p>\n\n\n\n

\n\n\n\n

66. Worthington, R.J., Bunders, C.A., Reed, C.S., and Melander, C. Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella penumoniae<\/em>. ACS Medicinal Chemistry Letters<\/em>, 2012 <\/strong>3 <\/em>(5), 357-361. <\/em>doi.org\/10.1021\/ml200290p<\/a><\/p>\n\n\n\n

\n\n\n\n

65. Lindsey, E.A., Worthington, R.J., Alcaraz, C., and Melander, C. 2-Aminopyrimidine as a Novel Scaffold for Biofilm Modulation. Organic and Biomolecular Chemistry, <\/em>2012<\/strong>, 10 <\/em>(13), 2552-2561. <\/em>doi.org\/10.1039\/c2ob06871k<\/a><\/p>\n\n\n\n

\n\n\n\n

64. Su, Z., Peng, L., and Melander, C. A Modular Approach to the Synthesis of 1,4,5-Substituted-2-Aminoimidazoles. Tetrahedron Letters,<\/em> 2012<\/strong>, 53 <\/em>(10), 1204-1206.<\/em> doi.org\/10.1016\/j.tetlet.2011.12.090<\/a><\/p>\n\n\n\n

\n\n\n\n

63. Budhathoki-Uprety, J., Peng, L., Melander, C., and Novak, B.M. Synthesis of Guanidinium Functionalized Polycarbodiimides and their Antibacterial Activities. ACS Macro Letters<\/em>, 2012 <\/strong>1 <\/em>(3), 370-374. <\/em>doi.org\/10.1021\/mz200116k<\/a><\/p>\n\n\n\n

\n\n\n\n

62. Olson, A.L., Bobay, B.G., Melander, C, and Cavanagh, J. 1<\/sup>H, 13<\/sup>C, and 15<\/sup>N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis<\/em>. Biomolecular NMR Assignments, <\/em>2012<\/strong>, 6<\/em>(1), 95-98. doi.org\/10.1007\/s12104-011-9333-2<\/a><\/p>\n\n\n\n

\n\n\n\n

61. Stowe, S.D., Tucker, A.T, Rogers, S.A., Richards, J.J., Melander, C., and Cavanagh, J. Evaluation of the Toxicity of  2-Aminoimidazole Antibiofilm Agents using both Cellular and Model Organism Systems. Drug and Chemical Toxicology<\/em>, 2012<\/strong>, 35 <\/em>(3), 310-315. doi.org\/10.3109\/01480545.2011.614620<\/a><\/p>\n\n\n\n

\n\n\n\n

60. Bunders, C.A., Minvielle, M.J., Worthington, R.J., Ortiz, M., Cavanagh, J., and Melander, C. Intercepting Bacterial Indole Signaling with Flustramine Derivatives. Journal of the American Chemical Society,<\/em> 2011<\/strong>, 133<\/em> (50), 20160-20163. doi.org\/10.1021\/ja209836z<\/a><\/p>\n\n\n\n

\n\n\n\n

59. Stowe, S.D., Richards, J.J., Tucker, A.T., Thompson, R., Melander, C, and Cavanagh, J. Anti-Biofilm Compounds Derived from Marine Sponges. Marine Drugs<\/em>, 2011<\/strong>, 9<\/em> (11), 2010-2035. doi.org\/10.3390\/md9102010<\/a><\/p>\n\n\n\n

\n\n\n\n

58. Su, Z., Peng, L., Worthington, R.J., and Melander, C. Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual Antibiofilm\/Antibiotic Resensitization Activity. ChemMedChem, <\/em>2011<\/strong>, 6<\/em>, 2243-2251. <\/em>doi.org\/10.1002\/cmdc.201100316<\/a><\/p>\n\n\n\n

\n\n\n\n

57. Harris, T., Worthington, R.J., and Melander, C. A Facile Synthesis of 1,5-Disubstituted-2-Aminoimidazoles: Antibiotic and Antibiofilm Activity of a First Generation Library. Bioorganic and Medicinal Chemistry Letters, <\/em>2011<\/strong>, 21 <\/em>(15), 4516-4519. <\/em>doi.org\/10.1016\/j.bmcl.2011.05.123<\/a><\/p>\n\n\n\n

\n\n\n\n

56. Bunders, C.A., Cavanagh, J., and Melander, C. Flustramine Inspired Synthesis and Biological Evaluation of Pyrroloindoline Triazole Amides as Novel Inhibitors of Bacterial Biofilms. Organic and Biomolecular Chemistry,<\/em> 2011<\/strong>, 9<\/em>, 5476-5481. <\/em>doi.org\/10.1039\/c1ob05605k<\/a><\/p>\n\n\n\n

\n\n\n\n

55. Bresee, J., Maier, K.E., Boncella, A.E., Melander, C.<\/strong>, and Feldheim, D.L. Growth Inhibition of Staphylococcus aureus<\/em> by Mixed Monolayer Gold Nanoparticles. Small<\/em>, 2011<\/strong>, 7<\/em> (14), 2027-2031. <\/em>doi.org\/10.1002\/smll.201100420<\/a><\/p>\n\n\n\n

\n\n\n\n

54. Peng, L., DeSousa, J., Su, Z., Novak, B.M., Nevzorov, A.A., Garland, E.R., and Melander, C. Inhibition of Acinetobacter baumannii <\/em>Biofilm Formation on a Methacrylate Polymer Containing a 2-Aminoimidazole Subunit. Chemical Communications<\/em>, 2011, <\/em><\/strong>47<\/em> (17), 4896-4898. doi.org\/10.1039\/C1CC10691K<\/a><\/p>\n\n\n\n

\n\n\n\n

53. Liu, C., Worthington, R.J., Melander, C., and Wu, H. A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans<\/em> in Multispecies Biofilms. Antimicrobial Agents and Chemotherapy, <\/em>2011<\/strong>, 55<\/em>(6), 2679-2687. <\/em>doi.org\/10.1128\/AAC.01496-10<\/a><\/p>\n\n\n\n

\n\n\n\n

52. Rogers, S.A., Lindsey, E.A, Whitehead, D.C., Mullikin, T. and Melander, C. Synthesis and Biological Evaluation of 2-Aminoimidazole\/Carbamate Hybrid Anti-biofilm and Antimicrobial Agents. Bioorganic and Medicinal Chemistry Letters, <\/em>2011<\/strong>, 21 <\/em>(4), 1257-1260. doi.org\/10.1016\/j.bmcl.2010.12.057<\/a><\/p>\n\n\n\n

\n\n\n\n

51. Reyes, S., Huigens, R.W., Su, Z., Simon, M.L., and Melander, C. Synthesis and Biological Activity of 2-Aminoimidazole Triazoles Accessed by Suzuki-Miyaura Cross-Coupling, Organic and Biomolecular Chemistry, <\/em>2011<\/strong>, 9<\/em>(8), 3041-3049. doi.org\/10.1039\/C0OB00925C<\/a><\/p>\n\n\n\n

\n\n\n\n

50. Bresee, J., Maier, K.E., Melander, C., and Feldheim, D.L. Identification of Antibiotics Using Small Molecule Variable Ligand Display on Gold Nanoparticles, Chemical Communications<\/em>, 2010<\/strong>, 46<\/em> (40), 7516-7518. <\/em>doi.org\/10.1039\/C0CC02663H<\/a><\/p>\n\n\n\n

\n\n\n\n

49. Reed, C.S., Huigens, R.W., Rogers, S.A., and Melander, C. Modulating the Development of E. coli<\/em> Biofilms with 2-Aminoimidazoles, Bioorganic and Medicinal Chemistry Letters,<\/em> 2010<\/strong>, 20<\/em> (21), 6310-6312. doi.org\/10.1016\/j.bmcl.2010.08.075<\/a><\/p>\n\n\n\n

\n\n\n\n

48. Rogers, S.A., Whitehead, D.C., Mullikin, T., and Melander, C. Synthesis and Bacterial Biofilm Inhibition Studies of Ethyl N-(2-Phenethyl) Carbamate Derivatives. Organic and Biomolecular Chemistry<\/em>, 2010<\/strong>, 8<\/em>, 3857-3859. doi.org\/10.1039\/C0OB00063A<\/a><\/p>\n\n\n\n

\n\n\n\n

47. Bunders, C., Richards, J.J., and Melander, C. Identification of Aryl 2-Aminoimidazoles as Biofilm Inhibitors of Gram-Negative Bacteria. Bioorganic and Medicinal Chemistry Letters,<\/em> 2010<\/strong>, 20 <\/em>(12), 3797-3800. <\/em>doi.org\/10.1016\/j.bmcl.2010.04.042<\/a><\/p>\n\n\n\n

\n\n\n\n

46. Su, Z., Rogers, S.A., McCall, W.S., Smith, A.C., Ravishankar, S., Mullikin, T., and Melander, C. A Nitroenolate Approach to the Synthesis of 4,5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity. Organic and Biomolecular Chemistry<\/em>, 2010<\/strong>, 8<\/em>(12), 2814-2822. doi.org\/10.1039\/C001479F<\/a><\/p>\n\n\n\n

\n\n\n\n

45. Rogers, S.A., Huigens, R.W., Cavanagh, J., and Melander, C. Synergistic Effects Between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents. Antimicrobial Agents and Chemotherapy<\/em>, 2010<\/strong>, 54<\/em>(5), 2112-2118. doi.org\/10.1128\/AAC.01418-09<\/a><\/p>\n\n\n\n

\n\n\n\n

44. Heinecke, C.L. and Melander, C. Analysis of Kinamycin D Mediated DNA Cleavage. Tetrahedron Letters<\/em>, 2010<\/strong>, 51<\/em> (11), 1455-1458. doi.org\/10.1016\/j.tetlet.2009.12.142<\/a><\/p>\n\n\n\n

\n\n\n\n

43. Huigens, R.W., Reyes, S., Reed, C.S., Bunders, C., Rogers, S.A., Steinhauer, A.T., and Melander, C. The Chemical Synthesis and Antibiotic Activity of a Diverse Library of 2-Aminobenzimidazole Small Molecules Against MRSA and Multidrug-Resistant A. baumannii<\/em>. Bioorganic and Medicinal Chemistry<\/em>, 2010<\/strong>, 18<\/em> (2), 663-674. doi.org\/10.1016\/j.bmc.2009.12.003<\/a><\/p>\n\n\n\n

\n\n\n\n

42. Rogers, S.A., Bero, J.D., and Melander, C. Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents. ChemBioChem<\/em>, 2010<\/strong>, 11<\/em> (3), 396-410. doi.org\/10.1002\/cbic.200900617<\/a><\/p>\n\n\n\n

\n\n\n\n

41. Richards, J.J. and Melander, C. Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance. Anti-Infective Agents in Medicinal Chemistry<\/em>, 2009<\/strong>, 8<\/em>, 295-314. doi.org\/10.2174\/187152109789760135<\/a><\/p>\n\n\n\n

\n\n\n\n

40. Richards, J.J. and Melander, C. Controlling Bacterial Biofilms. ChemBioChem<\/em>, 2009<\/strong>, 10<\/em> (14), 2287-2294. doi.org\/10.1002\/cbic.200900317<\/a><\/p>\n\n\n\n

\n\n\n\n

39. Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.; Ballard, T.E.; Cavanagh, J.; and Melander, C. Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans<\/em> Toxicity. Journal of Medicinal Chemistry<\/em>, 2009<\/strong>, 52 (15), 4582-4585. doi.org\/10.1021\/jm900378s<\/a><\/p>\n\n\n\n

\n\n\n\n

38. Rogers, S.A., Huigens, R.W., and Melander, C. A 2-Aminobenzimidazole that Inhibits and Disperses Gram-Positive Biofilms Through a Zinc-Dependent Mechanism. Journal of the American Chemical Society<\/em>, 2009<\/strong>, 131 (29), 9868\u20139869. doi.org\/10.1021\/ja9024676<\/a><\/p>\n\n\n\n

\n\n\n\n

37. Melander, C., Moeller, P.D.R., Ballard, T.E., Richards, J.J., Huigens, R.W., and Cavanagh, J. Evaluation of Dihydrooroidin as an Antifouling Additive in Marine Paint. International Biodeterioration & Biodegradation<\/em>. 2009<\/strong>, 63, 529-532. doi.org\/10.1016\/j.ibiod.2008.08.009<\/a><\/p>\n\n\n\n

\n\n\n\n

36. Ballard, T.E., Richards, J.J., Aquino, A., Reed, C.S. and Melander, C. Anti-biofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation. Journal of Organic Chemistry<\/em>, 2009<\/strong>, 74<\/em> (4), 1755-1758. doi.org\/10.1021\/jo802260t<\/a><\/p>\n\n\n\n

\n\n\n\n

35. Huigens, R.W., Rogers, S.A., Steinhauer, A.T., and Melander, C. Inhibition of Acinetobacter baumannii<\/em>, Staphylococcus aureus, <\/em>and Pseudomonas aeruginosa<\/em> Biofilms with a Class of TAGE-Triazole Conjugates. Organic and Biomolecular Chemistry,<\/em> 2009<\/strong>, 7<\/em> (4), 794-802. doi.org\/10.1039\/b817926c<\/a><\/p>\n\n\n\n

\n\n\n\n

34. Rogers, S.A., Krayer, M., Lindsey, J.S., and Melander, C. Tandem Dispersion and Killing of Bacteria from a Biofilm. Organic and Biomolecular Chemistry,<\/em> 2009<\/strong>, 7<\/em> (3), 603-606. doi.org\/10.1039\/b817923a<\/a><\/p>\n\n\n\n

\n\n\n\n

33. Ballard, T. E., Richards, J.J., Wolfe, A.L., and Melander, C. Synthesis and Anti-biofilm Activity of a Second Generation Reverse Amide Oroidin Library: An SAR Study. Chemistry a European Journal<\/em>, 2008<\/strong>, 14<\/em> (34), 10745-10761. doi.org\/10.1002\/chem.200801419<\/a><\/p>\n\n\n\n

\n\n\n\n

32. Richards, J.J., Reed, C.S., and Melander, C. Effects of N<\/em>-Pyrrole Substitution on the Anti-Biofilm Activities of Oroidin Derivatives Against Acinetobacter baumannii<\/em>. Bioorganic and Medicinal Chemistry Letters<\/em>, 2008<\/strong>, 18<\/em> (15), 4325-4327. doi.org\/10.1016\/j.bmcl.2008.06.089<\/a><\/p>\n\n\n\n

\n\n\n\n

31. Richards, J.J. and Melander, C. Synthesis of a 2-Aminoimidazole Library for Anti-Biofilm Screening Utilizing the Sonogashira Reaction. Journal of Organic Chemistry<\/em>, 2008, <\/strong>73 <\/em>(13), 5191-5193. doi.org\/10.1021\/jo800618q<\/a><\/p>\n\n\n\n

\n\n\n\n

30. Rogers, S.A. and Melander, C. Construction and Screening of a 2-Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms Across Order, Class, and Phylum. Angewandte Chemie,<\/em> 2008<\/strong>, 47<\/em> (28), 5229-5231. doi.org\/10.1002\/anie.200800862<\/a><\/p>\n\n\n\n

\n\n\n\n

29. Bowman, M.C., Ballard, T.E., Ackerson, C.J., Feldheim, D.J., Margolis, D.M., and Melander, C. Inhibition of HIV Fusion with Multivalent Gold Nanoparticles. Journal of the American Chemical Society,<\/em> 2008<\/strong>, 130<\/em> (22), 6896-6897. doi.org\/10.1021\/ja710321g<\/a><\/p>\n\n\n\n

\n\n\n\n

28. Ballard, T.E. and Melander, C. Kinamycin-Mediated Cleavage of DNA under Biomimetic Conditions. Tetrahedron Letters<\/em>. 2008<\/strong>, 49, 3157-3161. doi.org\/10.1016\/j.tetlet.2008.03.019<\/a><\/p>\n\n\n\n

\n\n\n\n

27. Richards, J.J., Ballard, T. E., Huigens, R.W., and Melander, C. Synthesis and Screening of an Oroidin Library Against Pseudomonas aeruginosa<\/em> Biofilms. ChemBioChem<\/em> 2008<\/strong>, 9<\/em> (8), 1267-1279.  doi.org\/10.1002\/cbic.200700774<\/a><\/p>\n\n\n\n

\n\n\n\n

26. Huigens, R.W., Ma, L., Gambino, C., Basso, A., Moeller, P.D.R., Cavanagh, J., Wozniak, D. J., and Melander, C. Control of Bacterial Biofilms with Marine Alkaloid Derivatives. Molecular BioSystems<\/em>, 2008<\/strong>, 4 <\/em>(6), 614-621. doi.org\/10.1039\/B719989A<\/a><\/p>\n\n\n\n

\n\n\n\n

25. Richards, J.J., Ballard, T.E., and Melander, C. Inhibition and Dispersion of Pseudomonas aeruginosa <\/em>Biofilms with Reverse Amide 2-Aminoimidazole Oroidin Analogues. Organic and Biomolecular Chemistry<\/em>, 2008<\/strong>, 6 (8), 1356-1363. doi.org\/10.1039\/b719082d<\/a><\/p>\n\n\n\n

\n\n\n\n

24. Richards, J.J., Huigens, R.W., Ballard, T. E., Basso, A., Cavanagh, J., and Melander, C. Inhibition and Dispersion of Proteobacterial Biofilms. Chemical Communications<\/em>, 2008<\/strong>, 14, 1698-1700. doi.org\/10.1039\/b719802g<\/a><\/p>\n\n\n\n

\n\n\n\n

23. Burns. V.A., Bobay, B.G., Basso, A., Cavanagh, J., and Melander, C. Targeting RNA with Cysteine-Constrained Peptides. Bioorganic & Medicinal Chemistry Letters<\/em>, 2008<\/strong>, 18<\/em> (2), 565-567. doi.org\/10.1016\/j.bmcl.2007.11.096<\/a><\/p>\n\n\n\n

\n\n\n\n

22. Huigens, R.W., Richards, J. J., Parise, G.; Ballard, T.E., Zeng, W., Deora, R., Melander, C. Inhibition of Pseudomonas aeruginosa<\/em> Biofilm Formation with Bromoageliferin Analogues. Journal of the American Chemical Society<\/em> 2007,<\/strong> 129<\/em>, (22), 6966-6967. doi.org\/10.1021\/ja069017t<\/a><\/p>\n\n\n\n

\n\n\n\n

21. Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., Melander, C. Mimicking the Biological Activity of Diazobenzo[b<\/em>]fluorene Natural Products with Electronically Tuned Diazofluorene Analogs. Bioorganic and Medicinal Chemistry Letters<\/em>, 2006<\/strong>, 16, (19), 5148-5151. doi.org\/10.1016\/j.bmcl.2006.07.024<\/a><\/p>\n\n\n\n

\n\n\n\n

20. Zeng, W., Ballard, T. E., Melander, C. Tuning the Oxidation Properties of Vanadium (V) Through Ligand Stoichiometry. Tetrahedron Letters<\/em> 2006<\/strong>, 47, (33), 5923-5926. doi.org\/10.1016\/j.tetlet.2006.06.051<\/a><\/p>\n\n\n\n

\n\n\n\n

19. Burnet, R., Melander, C., Puckett, J. W., Son, L. S., Wells, R. D., Dervan, P. B., and Gottesfeld, J. G. DNA sequence-specific polyamides alleviate transcriptional inhibition associated with long GAA.<\/sup>TTC repeats in Friedreich\u2019s ataxia. Proceedings of the National Academy of Science<\/em> 2006<\/strong>, 103<\/em> (91), 11497-11502.  doi.org\/10.1073\/pnas.0604939103<\/a><\/p>\n\n\n\n

\n\n\n\n

18. Gearha, M. D., Dickinson, L., Ehley, J., Melander, C., Dervan, P. B., Wright, P. E., Gottesfeld, J. M. Inhibition of DNA Binding by Human Estrogen-Related Receptor 2 and Estrogen Receptor a with Minor Groove Binding Polyamides. Biochemistry<\/em> 2005<\/strong>, 44<\/em> (11): 4196-4203.  doi.org\/10.1021\/bi047872o<\/a><\/p>\n\n\n\n

\n\n\n\n

17. Ylisastigui, L., Coull, J. J., Rucker, V. C., Melander, C., Bosch, R. J., Brodie, S. J., Corey, L., Sodora, D. L., Dervan, P. B., Margolis, D. M. Polyamides Reveal a Role for Repression in Latency within Resting T Cells of HIV-Infected Donors. Journal of Infectious Diseases <\/em>2004,<\/strong> 190<\/em>, (8), 1429-1437. doi.org\/10.1086\/423822<\/a><\/p>\n\n\n\n

\n\n\n\n

16. Melander, C., Burnett, R., Gottesfeld, J. M. Regulation of Gene Expression with Pyrrole-Imidazole Polyamides. Journal of Biotechnology <\/em>2004,<\/strong> 112<\/em>, (1-2), 195-220. doi.org\/10.1016\/j.jbiotec.2004.03.018<\/a><\/p>\n\n\n\n

\n\n\n\n

15. Dickinson, L. A., Burnett, R., Melander, C., Edelson, B. S., Arora, P. S., Dervan, P. B., Gottesfeld, J. M. Arresting Cancer Proliferation by Small-Molecule Gene Regulation. Chemistry & Biology <\/em>2004,<\/strong> 11<\/em>, (11), 1583-1594. doi.org\/10.1016\/j.chembiol.2004.09.004<\/a><\/p>\n\n\n\n

\n\n\n\n

14. Suto, R. K., Edayathumangalam, R. S., White, C., Melander, C., Gottesfeld, J. M., Dervan, P. B., Luger, K. Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-Binding Ligands. Journal of Molecular Biology <\/em>2003,<\/strong> 326<\/em>, (2), 371-380. doi.org\/10.1016\/S0022-2836(02)01407-9<\/a><\/p>\n\n\n\n

\n\n\n\n

13. Rucker, V. C., Melander, C., Dervan, P. B. Influence of beta-Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove. Helvetica Chimica Acta <\/em>2003,<\/strong> 86<\/em>, (6), 1839-1851. doi.org\/10.1002\/hlca.200390148<\/a><\/p>\n\n\n\n

\n\n\n\n

12. Rucker, V. C., Foister, S., Melander, C., Dervan, P. B. Sequence Specific Fluorescence Detection of Double Strand DNA. Journal of The American Chemical Society <\/em>2003,<\/strong> 125<\/em>, (5), 1195-1202. doi.org\/10.1021\/ja021011q<\/a><\/p>\n\n\n\n

\n\n\n\n

11. Dudouet, B., Burnett, R., Dickinson, L. A., Wood, M. R., Melander, C., Belitsky, J. M., Edelson, B., Wurtz, N., Briehn, C., Dervan, P. B., Gottesfeld, J. M. Accessibility of Nuclear Chromatin by DNA Binding Polyamides. Chemistry & Biology <\/em>2003,<\/strong> 10<\/em>, (9), 859-867. doi.org\/10.1016\/j.chembiol.2003.09.001<\/a><\/p>\n\n\n\n

\n\n\n\n

10. Gottesfeld, J. M., Belitsky, J. M., Melander, C., Dervan, P. B., Luger, K. Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands. Journal of Molecular Biology <\/em>2002,<\/strong> 321<\/em>, (2), 249-263. doi.org\/10.1016\/S0022-2836(02)00598-3<\/a><\/p>\n\n\n\n

\n\n\n\n

9. Ehley, J. A., Melander, C.<\/strong>, Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides. Molecular and Cellular Biology <\/em>2002,<\/strong> 22<\/em>, (6), 1723-1733. doi.org\/10.1128\/MCB.22.6.1723-1733.2002<\/a><\/p>\n\n\n\n

\n\n\n\n

8. Coull, J. J., He, G. C., Melander, C., Rucker, V. C., Dervan, P. B., Margolis, D. M. Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides. Journal of Virology <\/em>2002,<\/strong> 76<\/em>, (23), 12349-12354.  doi.org\/10.1128\/JVI.76.23.12349-12354.2002<\/a><\/p>\n\n\n\n

\n\n\n\n

7. Gottesfeld, J. M., Melander, C.<\/strong>, Suto, R., Raviol, H., Luger, K., Dervan, P. B. Sequence-Specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides. Journal of Molecular Biology <\/em>2001,<\/strong> 309<\/em>, (3), 615-629. doi.org\/10.1006\/jmbi.2001.4694<\/a><\/p>\n\n\n\n

\n\n\n\n

6. Baliga, R., Baird, E. E., Herman, D. M., Melander, C., Dervan, P. B., Crothers, D. M. Kinetic Consequences of Covalent Linkage of DNA Binding Polyamides. Biochemistry <\/em>2001,<\/strong> 40<\/em>, (1), 3-8. doi.org\/10.1021\/bi0022339<\/a><\/p>\n\n\n\n

\n\n\n\n

5. Melander, C., Herman, D. M., Dervan, P. B. Discrimination of A\/T Sequences in the Minor Groove of DNA within a Cyclic Polyamide Motif. Chemistry-A European Journal <\/em>2000,<\/strong> 6<\/em>, (24), 4487-4497. <a href="http:\/\/doi.org\/10.1002\/1521-3765(20001215)6:243.0.CO;2-C” target=”_blank” rel=”noopener noreferrer”>doi.org\/10.1002\/1521-3765(20001215)6:24<4487::AID-CHEM4487>3.0.CO;2-C<\/a><\/p>\n\n\n\n

\n\n\n\n

4. Melander, C.<\/strong>, Horne, D. A. Mutarotation of Tetramethylglucose Catalyzed by Ribonucleosides. Tetrahedron Letters <\/em>1997,<\/strong> 38<\/em>, (5), 713-716. doi.org\/10.1016\/S0040-4039(96)02422-7<\/a><\/p>\n\n\n\n

\n\n\n\n

3. Melander, C., Horne, D. A. Kinetic Analysis of Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Evidence of Bifunctional Catalysis. Journal of Organic Chemistry <\/em>1997,<\/strong> 62<\/em>, (26), 9295-9297. doi.org\/10.1021\/jo971614y<\/a><\/p>\n\n\n\n

\n\n\n\n

2. Melander, C., Horne, D. A. Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Journal of Organic Chemistry <\/em>1996,<\/strong> 61<\/em>, (23), 8344-8346. doi\/pdfplus\/10.1021\/jo961331q<\/a><\/p>\n\n\n\n

\n\n\n\n

1. Kurth, M. J., Randall, L. A. A., Chen, C. X., Melander, C.<\/strong>, Miller, R. B., Mcalister, K., Reitz, G., Kang, R., Nakatsu, T., Green, C. Library-Based Lead Compound Discovery-Antioxidants by an Analogous Synthesis Deconvolutive Assay Strategy. Journal of Organic Chemistry <\/em>1994,<\/strong> 59<\/em>, (20), 5862-5864. doi.org\/10.1021\/jo00099a008<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

185. Cowart, L. J., Nemeth, A. M., Jania, L. A., Overly,3 M., Ellis, C. F., Koller, B. H., Melander, R. J., Doi, Y., Ernst, R. K. and Melander, C. IMD-0354 Optimization Generates Potent Colistin Adjuvants with In vivo Activity and Reduced Eukaryotic Toxicity. European Journal of Medicinal Chemistry. Accepted 184. Kittleson, B., Woo, S., Marquez, … Continue reading “Publications”<\/span><\/a><\/p>\n","protected":false},"author":3360,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/users\/3360"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":283,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":1035,"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/pages\/18\/revisions\/1035"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/melanderlab\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}