{"id":1343,"date":"2022-07-07T16:05:21","date_gmt":"2022-07-07T20:05:21","guid":{"rendered":"https:\/\/sites.nd.edu\/pdnano\/?p=1343"},"modified":"2024-01-11T11:40:27","modified_gmt":"2024-01-11T15:40:27","slug":"ctsi-think-tank-seed-funding-to-explore-de-personalized-car-t-therapy-to-treat-solid-tumors","status":"publish","type":"post","link":"https:\/\/sites.nd.edu\/pdnano\/?p=1343","title":{"rendered":"CTSI-Think Tank Seed Funds our Efforts to facilitate CAR-T Therapy to Treat Solid Tumors."},"content":{"rendered":"
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Breast Cancer is the most widespread cancer and the second leading cause of cancer-related deaths among women in the U.S.A. As a treatment option, gene-modified T cells are under active therapeutic consideration for both hematological and solid malignancies. \u00a0As of 2016, there are 17 active TCR and 103 ongoing CAR-modified T cell studies registered through clinicaltrials.gov. Chimeric antigen receptors (CAR) T-cells are attractive as the affinity of (CAR) T-cell to the tumor surface antigen can be made high through protein engineering thus, promoting\u00a0 a strong anti-tumoral response. One of the biggest concern for efficient translation of CAR-T cells based therapies to solid tumors is the non-specific targeting of healthy tissue and organ systems, which have led to patient deaths.<\/p>\n\n\n\n

The CTSI think-tank has seeded our nanoparticle technology that will increase specificity of CAR-T cells to their target and not to healthy off-target tissue.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Breast Cancer is the most widespread cancer and the second leading cause of cancer-related deaths among women in the U.S.A. As a treatment option, gene-modified T cells are under active therapeutic consideration for both hematological and solid malignancies. \u00a0As of 2016, there are 17 active TCR and 103 ongoing CAR-modified T cell studies registered through … <\/p>\n

Continue reading »<\/a><\/p>\n","protected":false},"author":2672,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[313012,405093,405091,313541],"tags":[],"class_list":["post-1343","post","type-post","status-publish","format-standard","hentry","category-american-cancer-society","category-berthiaume-institute-for-precision-health","category-car-t","category-grants-funding"],"yoast_head":"\nCTSI-Think Tank Seed Funds our Efforts to facilitate CAR-T Therapy to Treat Solid Tumors. - Nallathamby Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=1343\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CTSI-Think Tank Seed Funds our Efforts to facilitate CAR-T Therapy to Treat Solid Tumors. - Nallathamby Laboratory\" \/>\n<meta property=\"og:description\" content=\"Breast Cancer is the most widespread cancer and the second leading cause of cancer-related deaths among women in the U.S.A. As a treatment option, gene-modified T cells are under active therapeutic consideration for both hematological and solid malignancies. \u00a0As of 2016, there are 17 active TCR and 103 ongoing CAR-modified T cell studies registered through … Continue reading »\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.nd.edu\/pdnano\/?p=1343\" \/>\n<meta property=\"og:site_name\" content=\"Nallathamby Laboratory\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/prakashdn\" \/>\n<meta property=\"article:published_time\" content=\"2022-07-07T20:05:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-11T15:40:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.nd.edu\/pdnano\/files\/2022\/11\/download.png\" \/>\n<meta name=\"author\" content=\"Prakash\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:site\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prakash\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1343#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1343\"},\"author\":{\"name\":\"Prakash\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"headline\":\"CTSI-Think Tank Seed Funds our Efforts to facilitate CAR-T Therapy to Treat Solid Tumors.\",\"datePublished\":\"2022-07-07T20:05:21+00:00\",\"dateModified\":\"2024-01-11T15:40:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1343\"},\"wordCount\":157,\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1343#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2022\\\/11\\\/download.png\",\"articleSection\":[\"American Cancer Society\",\"Berthiaume Institute for Precision Health\",\"CAR-T\",\"Grants funding\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1343\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1343\",\"name\":\"CTSI-Think Tank Seed Funds our Efforts to facilitate CAR-T Therapy to Treat Solid Tumors. - 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