{"id":1418,"date":"2022-09-16T19:50:52","date_gmt":"2022-09-16T23:50:52","guid":{"rendered":"https:\/\/sites.nd.edu\/pdnano\/?p=1418"},"modified":"2024-01-11T11:40:16","modified_gmt":"2024-01-11T15:40:16","slug":"mhsrs2022-combating-antibiotic-resistant-infections","status":"publish","type":"post","link":"https:\/\/sites.nd.edu\/pdnano\/?p=1418","title":{"rendered":"Nallathamby Lab Presents Phage-Mimicking Antibacterial Nanoparticle Results at Military Health Sciences Research Symposium 2022 in Orlando, Florida (Sept 12-15, 2022)"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"801\" height=\"474\" src=\"https:\/\/sites.nd.edu\/pdnano\/files\/2022\/11\/MHSRS_2022_800x473.png\" alt=\"\" class=\"wp-image-1419\" srcset=\"https:\/\/sites.nd.edu\/pdnano\/files\/2022\/11\/MHSRS_2022_800x473.png 801w, https:\/\/sites.nd.edu\/pdnano\/files\/2022\/11\/MHSRS_2022_800x473-300x178.png 300w, https:\/\/sites.nd.edu\/pdnano\/files\/2022\/11\/MHSRS_2022_800x473-768x454.png 768w\" sizes=\"auto, (max-width: 801px) 100vw, 801px\" \/><\/figure>\n\n\n\n<p>We are losing in an antibiotic arms race with bacteria due to the emergence and global spread of new antibiotic resistance mechanisms.<sup>1,2<\/sup> At current rates of antibiotics discovery and development we will eventually lose to antibiotic-resistant strains, and by 2050, antibiotics resistant strains of bacteria will kill more patients per year than all cancers combined. Therefore, there is a desperate need to look for methods beyond antibiotics to kill harmful bacteria and slow the rise of resistant bacterial pathogens. Our work described an antibiotic independent, structure-based antimicrobial system that is effective for topological applications (e.g., wound infections) while also effectively disrupting the bacterial populations at the surface of implant materials that are responsible for recurrent infections.<\/p>\n\n\n\n<p>We successfully mimicked the nanoarchitecture of antimicrobial viruses (Phages),<sup>3<\/sup> and clearly demonstrated a nanostructure dependent antimicrobial effect that will be a viable alternative to traditional antibiotics. &nbsp;The 100% bacterial killing rate achieved <em>in vitro<\/em> has allowed us to carry forward further research to validate these results in <em>in vivo<\/em> wound infection models.<\/p>\n\n\n\n<p><strong>Reference:<\/strong> <strong>[1]<\/strong> Ventola, C.L. P T 40, 277-83 (2015). <strong>[2]<\/strong>Zaman,S.B. et al. Cureus 9, e1403 (2017). <strong>[3]<\/strong> Abedon, S.T., Front Microbiol 8, 981 (2017).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are losing in an antibiotic arms race with bacteria due to the emergence and global spread of new antibiotic resistance mechanisms.1,2 At current rates of antibiotics discovery and development we will eventually lose to antibiotic-resistant strains, and by 2050, antibiotics resistant strains of bacteria will kill more patients per year than all cancers combined. &hellip; <\/p>\n<p><a class=\"more-link block-button\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=1418\">Continue reading &raquo;<\/a><\/p>\n","protected":false},"author":2672,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[313540,277371,405093],"tags":[],"class_list":["post-1418","post","type-post","status-publish","format-standard","hentry","category-antibiotics","category-antimicrobial","category-berthiaume-institute-for-precision-health"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nallathamby Lab Presents Phage-Mimicking Antibacterial Nanoparticle Results at Military Health Sciences Research Symposium 2022 in Orlando, Florida (Sept 12-15, 2022) - Nallathamby Laboratory<\/title>\n<meta name=\"description\" content=\"We are losing in an antibiotic arms race with bacteria due to the emergence and global spread of new antibiotic resistance mechanisms. Our work described an antibiotic independent, structure-based antimicrobial system that is effective.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=1418\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nallathamby Lab Presents Phage-Mimicking Antibacterial Nanoparticle Results at Military Health Sciences Research Symposium 2022 in Orlando, Florida (Sept 12-15, 2022) - Nallathamby Laboratory\" \/>\n<meta property=\"og:description\" content=\"We are losing in an antibiotic arms race with bacteria due to the emergence and global spread of new antibiotic resistance mechanisms. Our work described an antibiotic independent, structure-based antimicrobial system that is effective.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.nd.edu\/pdnano\/?p=1418\" \/>\n<meta property=\"og:site_name\" content=\"Nallathamby Laboratory\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/prakashdn\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T23:50:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-11T15:40:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.nd.edu\/pdnano\/files\/2022\/11\/MHSRS_2022_800x473.png\" \/>\n<meta name=\"author\" content=\"Prakash\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:site\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prakash\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418\"},\"author\":{\"name\":\"Prakash\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"headline\":\"Nallathamby Lab Presents Phage-Mimicking Antibacterial Nanoparticle Results at Military Health Sciences Research Symposium 2022 in Orlando, Florida (Sept 12-15, 2022)\",\"datePublished\":\"2022-09-16T23:50:52+00:00\",\"dateModified\":\"2024-01-11T15:40:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418\"},\"wordCount\":205,\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2022\\\/11\\\/MHSRS_2022_800x473.png\",\"articleSection\":[\"antibiotics\",\"Antimicrobial\",\"Berthiaume Institute for Precision Health\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418\",\"name\":\"Nallathamby Lab Presents Phage-Mimicking Antibacterial Nanoparticle Results at Military Health Sciences Research Symposium 2022 in Orlando, Florida (Sept 12-15, 2022) - Nallathamby Laboratory\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=1418#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2022\\\/11\\\/MHSRS_2022_800x473.png\",\"datePublished\":\"2022-09-16T23:50:52+00:00\",\"dateModified\":\"2024-01-11T15:40:16+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"description\":\"We are losing in an antibiotic arms race with bacteria due to the emergence and global spread of new antibiotic resistance mechanisms. 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