{"id":633,"date":"2018-05-01T22:51:10","date_gmt":"2018-05-02T02:51:10","guid":{"rendered":"http:\/\/sites.nd.edu\/pdnano\/?p=633"},"modified":"2024-01-11T11:44:37","modified_gmt":"2024-01-11T15:44:37","slug":"cd133-cancer-stem-cells-role-in-metastatis","status":"publish","type":"post","link":"https:\/\/sites.nd.edu\/pdnano\/?p=633","title":{"rendered":"CD133+ Cancer Stem Cells Role in Metastasis"},"content":{"rendered":"<p>Excited for the <a href=\"http:\/\/journals.sagepub.com\/doi\/10.1177\/1179064418767882\" target=\"_blank\" rel=\"noopener\">2nd publication<\/a> this year through collaborative efforts with Harper Cancer Research Institute&#8217;s Karen Dahl (Title:<a href=\"http:\/\/journals.sagepub.com\/doi\/10.1177\/1179064418767882\" target=\"_blank\" rel=\"noopener\">\u00a0CD133 Promotes Adhesion to the Ovarian Cancer Metastatic Niche<\/a>). I did the 3D confocal imaging that showed CD133+ ovarian cancer cells clearly penetrate the basal epithelial cells, pointing to metastatic potential of stem cell like cancer cells. Looking forward to publishing more data this year\u00a0on using novel bi-modal nanoprobes for targeted imaging of CD133+ ovarian cancer stem cells in vitro and in an in vivo model system.<\/p>\n<div id=\"attachment_634\" style=\"width: 310px\" class=\"wp-caption alignnone\"><a href=\"http:\/\/journals.sagepub.com\/action\/downloadFigures?id=fig3-1179064418767882&amp;doi=10.1177\/1179064418767882\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-634\" class=\"wp-image-634 size-medium\" src=\"http:\/\/sites.nd.edu\/pdnano\/files\/2018\/05\/10.1177_1179064418767882-fig3-300x283.gif\" alt=\"\" width=\"300\" height=\"283\" \/><\/a><p id=\"caption-attachment-634\" class=\"wp-caption-text\">(C) Representative Skov3IP-RFP and Skov3IP-PROM1 spheroids shown by fluorescence microscopy (original magnification \u00d710). (D) Representative Skov3IP-RFP and Skov3IP-PROM1 are shown as a Z-stack using confocal fluorescence microscopy (original magnification \u00d740). GFP indicates green fluorescent protein<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Excited for the 2nd publication this year through collaborative efforts with Harper Cancer Research Institute&#8217;s Karen Dahl (Title:\u00a0CD133 Promotes Adhesion to the Ovarian Cancer Metastatic Niche). I did the 3D confocal imaging that showed CD133+ ovarian cancer cells clearly penetrate the basal epithelial cells, pointing to metastatic potential of stem cell like cancer cells. Looking &hellip; <\/p>\n<p><a class=\"more-link block-button\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=633\">Continue reading &raquo;<\/a><\/p>\n","protected":false},"author":2672,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[405093,259656,271078,270417,39411,259341],"tags":[],"class_list":["post-633","post","type-post","status-publish","format-standard","hentry","category-berthiaume-institute-for-precision-health","category-biomedical-imaging","category-cancer-stem-cells","category-fluorescence","category-harper-cancer-research-institute","category-upcoming-manuscripts"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CD133+ Cancer Stem Cells Role in Metastasis - Nallathamby Laboratory<\/title>\n<meta name=\"description\" content=\"CD133 promotes adhesion to the ovarian cancer metastatic niche as determined using 3D confocal imaging\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=633\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CD133+ Cancer Stem Cells Role in Metastasis - Nallathamby Laboratory\" \/>\n<meta property=\"og:description\" content=\"CD133 promotes adhesion to the ovarian cancer metastatic niche as determined using 3D confocal imaging\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.nd.edu\/pdnano\/?p=633\" \/>\n<meta property=\"og:site_name\" content=\"Nallathamby Laboratory\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/prakashdn\" \/>\n<meta property=\"article:published_time\" content=\"2018-05-02T02:51:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-11T15:44:37+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.nd.edu\/pdnano\/files\/2018\/05\/10.1177_1179064418767882-fig3-300x283.gif\" \/>\n<meta name=\"author\" content=\"Prakash\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:site\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prakash\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=633#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=633\"},\"author\":{\"name\":\"Prakash\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"headline\":\"CD133+ Cancer Stem Cells Role in Metastasis\",\"datePublished\":\"2018-05-02T02:51:10+00:00\",\"dateModified\":\"2024-01-11T15:44:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=633\"},\"wordCount\":138,\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=633#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2018\\\/05\\\/10.1177_1179064418767882-fig3-300x283.gif\",\"articleSection\":[\"Berthiaume Institute for Precision Health\",\"Biomedical Imaging\",\"Cancer stem cells\",\"Fluorescence\",\"Harper Cancer Research Institute\",\"Upcoming manuscripts\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=633\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=633\",\"name\":\"CD133+ Cancer Stem Cells Role in Metastasis - 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