{"id":720,"date":"2018-08-30T14:25:16","date_gmt":"2018-08-30T18:25:16","guid":{"rendered":"http:\/\/sites.nd.edu\/pdnano\/?p=720"},"modified":"2024-01-11T11:44:01","modified_gmt":"2024-01-11T15:44:01","slug":"nanoparticles-that-act-as-an-on-and-off-switch-to-improve-the-safety-and-effectiveness-of-car-t-cancer-therapy","status":"publish","type":"post","link":"https:\/\/sites.nd.edu\/pdnano\/?p=720","title":{"rendered":"Nanoparticles that act as an \u201cON and OFF\u201d switch to improve the safety and effectiveness of CAR-T cancer therapy"},"content":{"rendered":"
Always thankful for the internal support from Notre Dame Research #notredameresearch<\/span><\/span><\/a>\u00a0for supporting high risk-high gain projects such as mine. Here’s hoping that my faculty research support program initiation grant (FRSP-IG) #FRSP<\/span><\/span><\/a> will pave the way for safer, more accessible CAR-T therapies and better quality of life for patients.<\/span><\/div>\n
https:\/\/research.nd.edu\/news\/developing-an-on-and-off-switch-for-breast-cancer-treatment\/<\/a><\/div>\n

The biggest bottle neck in Chimeric antigen receptor T-Cell (CAR-T cell) therapy is the 21 days it takes to expand the patient\u2019s T cells before re-infusion into the patient\u2019s blood. For many end-stage cancer patients the 21 day wait-period is a death sentence. We propose to explore a 3-part CAR-T cell therapy with only a 2 day wait time before start of therapy.\u00a0 Secondly, current state-of-the art in CAR-T cell technology is only effective against bloodborne malignancies (e.g. acute lymphoblastic leukemia). CAR-T cell clinical trials against solid malignancies has resulted in poor to fatal results. Reasons for the poor performance has been off-target activation, Tumor lysis syndrome (TLS), Cytokine release syndrome (CRS) and persistent \u201cON\u201d state of cytotoxic CAR-T cells. Recent literature on the switchable CAR-T cell (sCAR-T-cell) system proposed by two research teams uses a small-molecule switch that has bispecific binding domains directed to the tumor and the sCAR-T cells to redirect the sCAR-T cells to the tumor site. However, at the ideal switch concentration no amelioration of the signs related to both CRS and TLS were observed in comparison to the suicide gene auto-destruct CAR T-cell strategy, with a daily or every other day administration. We propose to explore a non-genetic, quick off switch for the gCAR-T cells in order to reduce off target activation, CRS and TLS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Always thankful for the internal support from Notre Dame Research #notredameresearch\u00a0for supporting high risk-high gain projects such as mine. Here’s hoping that my faculty research support program initiation grant (FRSP-IG) #FRSP will pave the way for safer, more accessible CAR-T therapies and better quality of life for patients. https:\/\/research.nd.edu\/news\/developing-an-on-and-off-switch-for-breast-cancer-treatment\/ The biggest bottle neck in Chimeric … <\/p>\n

Continue reading »<\/a><\/p>\n","protected":false},"author":2672,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[311061,405093,311661,39411,271377,311330,277736],"tags":[277736],"class_list":["post-720","post","type-post","status-publish","format-standard","hentry","category-adt-notre-dame","category-berthiaume-institute-for-precision-health","category-combination-chemotherapy","category-harper-cancer-research-institute","category-immunotherapy","category-metastatic-cancer-cells","category-ndnano","tag-ndnano"],"yoast_head":"\nNanoparticles that act as an \u201cON and OFF\u201d switch to improve the safety and effectiveness of CAR-T cancer therapy - Nallathamby Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=720\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nanoparticles that act as an \u201cON and OFF\u201d switch to improve the safety and effectiveness of CAR-T cancer therapy - Nallathamby Laboratory\" \/>\n<meta property=\"og:description\" content=\"Always thankful for the internal support from Notre Dame Research #notredameresearch\u00a0for supporting high risk-high gain projects such as mine. Here’s hoping that my faculty research support program initiation grant (FRSP-IG) #FRSP will pave the way for safer, more accessible CAR-T therapies and better quality of life for patients. https:\/\/research.nd.edu\/news\/developing-an-on-and-off-switch-for-breast-cancer-treatment\/ The biggest bottle neck in Chimeric … Continue reading »\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.nd.edu\/pdnano\/?p=720\" \/>\n<meta property=\"og:site_name\" content=\"Nallathamby Laboratory\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/prakashdn\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-30T18:25:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-11T15:44:01+00:00\" \/>\n<meta name=\"author\" content=\"Prakash\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:site\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prakash\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=720#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=720\"},\"author\":{\"name\":\"Prakash\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"headline\":\"Nanoparticles that act as an \u201cON and OFF\u201d switch to improve the safety and effectiveness of CAR-T cancer therapy\",\"datePublished\":\"2018-08-30T18:25:16+00:00\",\"dateModified\":\"2024-01-11T15:44:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=720\"},\"wordCount\":295,\"keywords\":[\"NDNano\"],\"articleSection\":[\"AD&T Notre Dame\",\"Berthiaume Institute for Precision Health\",\"Combination chemotherapy\",\"Harper Cancer Research Institute\",\"Immunotherapy\",\"metastatic cancer cells\",\"NDNano\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=720\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=720\",\"name\":\"Nanoparticles that act as an \u201cON and OFF\u201d switch to improve the safety and effectiveness of CAR-T cancer therapy - 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