{"id":857,"date":"2019-04-08T09:00:12","date_gmt":"2019-04-08T13:00:12","guid":{"rendered":"http:\/\/sites.nd.edu\/pdnano\/?p=857"},"modified":"2024-01-11T11:41:52","modified_gmt":"2024-01-11T15:41:52","slug":"label-free-magnetic-nanocarrier-based-precision-combinatorial-chemotherapeutics-treatment-against-metastatic-cancer-for-recurrence-free-survival","status":"publish","type":"post","link":"https:\/\/sites.nd.edu\/pdnano\/?p=857","title":{"rendered":"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival"},"content":{"rendered":"

\u256a1,3Margo Waters, \u256a1,3Juliane Hopf, 1,3Paul Helquist, 2Vincent Jo Davisson, and 1,3Prakash. D. Nallathamby<\/p>\n

1<\/sup>University of Notre Dame, Notre Dame USA; 2<\/sup>Purdue University, Lafayette, USA; 3<\/sup>NDnano, Notre Dame, USA<\/p>\n

\u256a Equal contributors<\/sup><\/p>\n

The leading cause of fatalities in breast cancer is metastasis.1<\/sup> To increase the success rate of metastasis-free survival, there is a need to tackle therapy-resistant metastatic forms of the disease with novel, patient-friendly, combinatorial treatment regimens. At present, doxorubicin (Dox) regimens are standard of care for tumor debulking but do not stop metastatic recurrence and present cardiotoxicity. Vacuolar ATPase (V-ATPase) H+<\/sup> pump inhibitors (e.g., diphyllins) prevent metastasis, but the ubiquitous occurrence of this target raises concerns of off-target toxicity.2<\/sup> A solution is targeted delivery to reduce off-target effects while also minimizing drug dose side-effects.3<\/sup> So, here we present the successful demonstration of targeted combinatorial-delivery of V-ATPase inhibitors (Diph) and standard chemotherapeutics (Dox) to the MDAMB231 triple negative breast cancer metastatic cell model\u00a0 (2D and 3D) with positive cell clearance and affirmative inhibition of cancer cell invasion. Our drug delivery system used a label-free magnetoelectric system.<\/p>\n

Congratulations to Dr.Hopf and undergraduate researcher Margo Waters for their contributions to these excellent results.<\/p>\n

References<\/strong> : [1]<\/strong> Dubey, A.K., et al. Asian Pac J Cancer Prev 16, 4237-45 (2015). [2]<\/strong> McHenry, P. et al. J Cell Biochem 109, 634-42 (2010). [3]<\/strong> Huang, T. et al. Anal Chem 79, 7708-18 (2007).<\/p>\n

\"\" \"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

\u256a1,3Margo Waters, \u256a1,3Juliane Hopf, 1,3Paul Helquist, 2Vincent Jo Davisson, and 1,3Prakash. D. Nallathamby 1University of Notre Dame, Notre Dame USA; 2Purdue University, Lafayette, USA; 3NDnano, Notre Dame, USA \u256a Equal contributors The leading cause of fatalities in breast cancer is metastasis.1 To increase the success rate of metastasis-free survival, there is a need to tackle … <\/p>\n

Continue reading »<\/a><\/p>\n","protected":false},"author":2672,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[311061,313012,405093,311661,39411,277736],"tags":[277736],"class_list":["post-857","post","type-post","status-publish","format-standard","hentry","category-adt-notre-dame","category-american-cancer-society","category-berthiaume-institute-for-precision-health","category-combination-chemotherapy","category-harper-cancer-research-institute","category-ndnano","tag-ndnano"],"yoast_head":"\nLabel-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival - Nallathamby Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=857\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival - Nallathamby Laboratory\" \/>\n<meta property=\"og:description\" content=\"\u256a1,3Margo Waters, \u256a1,3Juliane Hopf, 1,3Paul Helquist, 2Vincent Jo Davisson, and 1,3Prakash. D. Nallathamby 1University of Notre Dame, Notre Dame USA; 2Purdue University, Lafayette, USA; 3NDnano, Notre Dame, USA \u256a Equal contributors The leading cause of fatalities in breast cancer is metastasis.1 To increase the success rate of metastasis-free survival, there is a need to tackle … Continue reading »\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.nd.edu\/pdnano\/?p=857\" \/>\n<meta property=\"og:site_name\" content=\"Nallathamby Laboratory\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/prakashdn\" \/>\n<meta property=\"article:published_time\" content=\"2019-04-08T13:00:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-11T15:41:52+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/04\/IMG_20190-300x225.jpg\" \/>\n<meta name=\"author\" content=\"Prakash\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:site\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prakash\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857\"},\"author\":{\"name\":\"Prakash\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"headline\":\"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival\",\"datePublished\":\"2019-04-08T13:00:12+00:00\",\"dateModified\":\"2024-01-11T15:41:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857\"},\"wordCount\":233,\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/04\\\/IMG_20190-300x225.jpg\",\"keywords\":[\"NDNano\"],\"articleSection\":[\"AD&T Notre Dame\",\"American Cancer Society\",\"Berthiaume Institute for Precision Health\",\"Combination chemotherapy\",\"Harper Cancer Research Institute\",\"NDNano\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857\",\"name\":\"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival - Nallathamby Laboratory\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/04\\\/IMG_20190-300x225.jpg\",\"datePublished\":\"2019-04-08T13:00:12+00:00\",\"dateModified\":\"2024-01-11T15:41:52+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857#primaryimage\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/04\\\/IMG_20190.jpg\",\"contentUrl\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/04\\\/IMG_20190.jpg\",\"width\":3000,\"height\":2250},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=857#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#website\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/\",\"name\":\"Modular Nanotechnologies and Nanomaterials\",\"description\":\"Modular and scalable nanotechnology for imaging, sensing and therapeutics\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\",\"name\":\"Prakash\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?author=2672\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival - Nallathamby Laboratory","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.nd.edu\/pdnano\/?p=857","og_locale":"en_US","og_type":"article","og_title":"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival - Nallathamby Laboratory","og_description":"\u256a1,3Margo Waters, \u256a1,3Juliane Hopf, 1,3Paul Helquist, 2Vincent Jo Davisson, and 1,3Prakash. D. Nallathamby 1University of Notre Dame, Notre Dame USA; 2Purdue University, Lafayette, USA; 3NDnano, Notre Dame, USA \u256a Equal contributors The leading cause of fatalities in breast cancer is metastasis.1 To increase the success rate of metastasis-free survival, there is a need to tackle … Continue reading »","og_url":"https:\/\/sites.nd.edu\/pdnano\/?p=857","og_site_name":"Nallathamby Laboratory","article_publisher":"https:\/\/www.facebook.com\/prakashdn","article_published_time":"2019-04-08T13:00:12+00:00","article_modified_time":"2024-01-11T15:41:52+00:00","og_image":[{"url":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/04\/IMG_20190-300x225.jpg","type":"","width":"","height":""}],"author":"Prakash","twitter_card":"summary_large_image","twitter_creator":"@prakashdn","twitter_site":"@prakashdn","twitter_misc":{"Written by":"Prakash","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857#article","isPartOf":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857"},"author":{"name":"Prakash","@id":"https:\/\/sites.nd.edu\/pdnano\/#\/schema\/person\/3bec2d9fbd957b23abd53a0a5445b4f0"},"headline":"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival","datePublished":"2019-04-08T13:00:12+00:00","dateModified":"2024-01-11T15:41:52+00:00","mainEntityOfPage":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857"},"wordCount":233,"image":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857#primaryimage"},"thumbnailUrl":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/04\/IMG_20190-300x225.jpg","keywords":["NDNano"],"articleSection":["AD&T Notre Dame","American Cancer Society","Berthiaume Institute for Precision Health","Combination chemotherapy","Harper Cancer Research Institute","NDNano"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857","url":"https:\/\/sites.nd.edu\/pdnano\/?p=857","name":"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival - Nallathamby Laboratory","isPartOf":{"@id":"https:\/\/sites.nd.edu\/pdnano\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857#primaryimage"},"image":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857#primaryimage"},"thumbnailUrl":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/04\/IMG_20190-300x225.jpg","datePublished":"2019-04-08T13:00:12+00:00","dateModified":"2024-01-11T15:41:52+00:00","author":{"@id":"https:\/\/sites.nd.edu\/pdnano\/#\/schema\/person\/3bec2d9fbd957b23abd53a0a5445b4f0"},"breadcrumb":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.nd.edu\/pdnano\/?p=857"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857#primaryimage","url":"https:\/\/sites.nd.edu\/pdnano\/files\/2019\/04\/IMG_20190.jpg","contentUrl":"https:\/\/sites.nd.edu\/pdnano\/files\/2019\/04\/IMG_20190.jpg","width":3000,"height":2250},{"@type":"BreadcrumbList","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=857#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.nd.edu\/pdnano\/"},{"@type":"ListItem","position":2,"name":"Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival"}]},{"@type":"WebSite","@id":"https:\/\/sites.nd.edu\/pdnano\/#website","url":"https:\/\/sites.nd.edu\/pdnano\/","name":"Modular Nanotechnologies and Nanomaterials","description":"Modular and scalable nanotechnology for imaging, sensing and therapeutics","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.nd.edu\/pdnano\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/sites.nd.edu\/pdnano\/#\/schema\/person\/3bec2d9fbd957b23abd53a0a5445b4f0","name":"Prakash","url":"https:\/\/sites.nd.edu\/pdnano\/?author=2672"}]}},"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts\/857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/users\/2672"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=857"}],"version-history":[{"count":5,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts\/857\/revisions"}],"predecessor-version":[{"id":869,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts\/857\/revisions\/869"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}