{"id":926,"date":"2019-11-08T12:17:23","date_gmt":"2019-11-08T16:17:23","guid":{"rendered":"http:\/\/sites.nd.edu\/pdnano\/?p=926"},"modified":"2024-01-10T17:14:23","modified_gmt":"2024-01-10T21:14:23","slug":"fighting-antibiotic-resistant-bacteria-by-skipping-anitbiotics","status":"publish","type":"post","link":"https:\/\/sites.nd.edu\/pdnano\/?p=926","title":{"rendered":"Fighting antibiotic resistant bacteria by skipping anitbiotics"},"content":{"rendered":"<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2019\/na\/c9na00461k?page=search\"><strong>Phage-mimicking antibacterial core\u2013shell nanoparticles.<\/strong><\/a><\/p>\n<p>Excited to have started publishing and filing for a patent on our antibiotic-free antimicrobial nanoparticles research. More to come in the following months! Thankful for the support from <a id=\"ember5079\" class=\"hashtag-link ember-view\" href=\"https:\/\/www.linkedin.com\/feed\/hashtag\/?highlightedUpdateUrns=urn%3Ali%3Aactivity%3A6598590445389959168&amp;keywords=%23notredame&amp;originTrackingId=KdotpVDTQwuxQsoBdYwCEA%3D%3D\" target=\"_self\" rel=\"noopener noreferrer\" data-control-name=\"hashtag\"><span id=\"ember5080\" class=\"hashtag-a11y ember-view\" dir=\"ltr\"><span aria-hidden=\"true\">#<\/span><span class=\"hashtag-a11y__name\">notredame<\/span><\/span><\/a> <a id=\"ember5083\" class=\"hashtag-link ember-view\" href=\"https:\/\/www.linkedin.com\/feed\/hashtag\/?highlightedUpdateUrns=urn%3Ali%3Aactivity%3A6598590445389959168&amp;keywords=%23ideacenter&amp;originTrackingId=KdotpVDTQwuxQsoBdYwCEA%3D%3D\" target=\"_self\" rel=\"noopener noreferrer\" data-control-name=\"hashtag\"><span id=\"ember5084\" class=\"hashtag-a11y ember-view\" dir=\"ltr\"><span aria-hidden=\"true\">#<\/span><span class=\"hashtag-a11y__name\">ideacenter<\/span><\/span><\/a> <a id=\"ember5087\" class=\"hashtag-link ember-view\" href=\"https:\/\/www.linkedin.com\/feed\/hashtag\/?highlightedUpdateUrns=urn%3Ali%3Aactivity%3A6598590445389959168&amp;keywords=%23antibioticresistance&amp;originTrackingId=KdotpVDTQwuxQsoBdYwCEA%3D%3D\" target=\"_self\" rel=\"noopener noreferrer\" data-control-name=\"hashtag\"><span id=\"ember5088\" class=\"hashtag-a11y ember-view\" dir=\"ltr\"><span aria-hidden=\"true\">#<\/span><span class=\"hashtag-a11y__name\">antibioticresistance<\/span><\/span><\/a> <a id=\"ember5091\" class=\"hashtag-link ember-view\" href=\"https:\/\/www.linkedin.com\/feed\/hashtag\/?highlightedUpdateUrns=urn%3Ali%3Aactivity%3A6598590445389959168&amp;keywords=%23ndnano&amp;originTrackingId=KdotpVDTQwuxQsoBdYwCEA%3D%3D\" target=\"_self\" rel=\"noopener noreferrer\" data-control-name=\"hashtag\"><span id=\"ember5092\" class=\"hashtag-a11y ember-view\" dir=\"ltr\"><span aria-hidden=\"true\">#<\/span><span class=\"hashtag-a11y__name\">ndnano<\/span><\/span><\/a> <a id=\"ember5095\" class=\"hashtag-link ember-view\" href=\"https:\/\/www.linkedin.com\/feed\/hashtag\/?highlightedUpdateUrns=urn%3Ali%3Aactivity%3A6598590445389959168&amp;keywords=%23Advanceddiagnosticsandtherapeutics&amp;originTrackingId=KdotpVDTQwuxQsoBdYwCEA%3D%3D\" target=\"_self\" rel=\"noopener noreferrer\" data-control-name=\"hashtag\"><span id=\"ember5096\" class=\"hashtag-a11y ember-view\" dir=\"ltr\"><span aria-hidden=\"true\">#<\/span><span class=\"hashtag-a11y__name\">Advanceddiagnosticsandtherapeutics<\/span><\/span><\/a> <a id=\"ember5099\" class=\"hashtag-link ember-view\" href=\"https:\/\/www.linkedin.com\/feed\/hashtag\/?highlightedUpdateUrns=urn%3Ali%3Aactivity%3A6598590445389959168&amp;keywords=%23ADandT&amp;originTrackingId=KdotpVDTQwuxQsoBdYwCEA%3D%3D\" target=\"_self\" rel=\"noopener noreferrer\" data-control-name=\"hashtag\"><span id=\"ember5100\" class=\"hashtag-a11y ember-view\" dir=\"ltr\"><span aria-hidden=\"true\">#<\/span><span class=\"hashtag-a11y__name\">ADandT<\/span><\/span><\/a> <a id=\"ember5103\" class=\"hashtag-link ember-view\" href=\"https:\/\/www.linkedin.com\/feed\/hashtag\/?highlightedUpdateUrns=urn%3Ali%3Aactivity%3A6598590445389959168&amp;keywords=%23openaccess&amp;originTrackingId=KdotpVDTQwuxQsoBdYwCEA%3D%3D\" target=\"_self\" rel=\"noopener noreferrer\" data-control-name=\"hashtag\"><span id=\"ember5104\" class=\"hashtag-a11y ember-view\" dir=\"ltr\"><span aria-hidden=\"true\">#<\/span><span class=\"hashtag-a11y__name\">openaccess<\/span><\/span><\/a><\/p>\n<p>The increasing frequency of nosocomial infections caused by antibiotic-resistant microorganisms concurrent with the stagnant discovery of new classes of antibiotics has made the development of new antibacterial agents a critical priority. Our approach is an antibiotic-free strategy drawing inspiration from bacteriophages to combat antibiotic-resistant bacteria. We developed a nanoparticle-based antimicrobial system that structurally mimics the protein-turret distribution on the head structure of certain bacteriophages and explores a combination of different materials arranged hierarchically to inhibit bacterial growth and ultimately kill pathogenic bacteria. Here, we describe the synthesis of phage-mimicking antibacterial nanoparticles (ANPs) consisting of gold silver-coated gold nanospheres distributed randomly on a silica core. The silver-coating was deposited in an anisotropic fashion on the gold nanospheres. Structurally, our nanoparticles mimicked the bacteriophages of the family <em>Microviridae<\/em> by up to 88%. These phage-mimicking ANPs were tested for bactericidal efficacy against four clinically relevant nosocomial pathogens (<em>Staphylococcus aureus <\/em>USA300<em>, Pseudomonas aeruginosa <\/em>FRD1<em>, Enterococcus faecalis, Corynebacterium striatum<\/em>) and their biocompatibility with skin cells. Bacterial growth of all four bacteria was inhibited (21% to 90%) as well as delayed (by up to 5h). The Gram-positive organisms were shown to be more sensitive to the nanoparticle treatment. Importantly, the phage-mimicking ANPs did not show any significant cytotoxic effects against human skin keratinocytes. Our results indicate the potential for phage-mimicking antimicrobial nanoparticles as a highly effective, alternative antibacterial agent, which may be suitable for co-administration with existing available formulations.<\/p>\n<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2019\/na\/c9na00461k?page=search\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-927\" src=\"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png\" alt=\"\" width=\"300\" height=\"150\" srcset=\"https:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png 300w, https:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-768x384.png 768w, https:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-1024x512.png 1024w, https:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-340x170.png 340w, https:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract.png 1890w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Phage-mimicking antibacterial core\u2013shell nanoparticles. Excited to have started publishing and filing for a patent on our antibiotic-free antimicrobial nanoparticles research. More to come in the following months! Thankful for the support from #notredame #ideacenter #antibioticresistance #ndnano #Advanceddiagnosticsandtherapeutics #ADandT #openaccess The increasing frequency of nosocomial infections caused by antibiotic-resistant microorganisms concurrent with the stagnant discovery of &hellip; <\/p>\n<p><a class=\"more-link block-button\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=926\">Continue reading &raquo;<\/a><\/p>\n","protected":false},"author":2672,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[313540,277371,405093,313539],"tags":[],"class_list":["post-926","post","type-post","status-publish","format-standard","hentry","category-antibiotics","category-antimicrobial","category-berthiaume-institute-for-precision-health","category-multidrug-resistance"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fighting antibiotic resistant bacteria by skipping anitbiotics - Nallathamby Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.nd.edu\/pdnano\/?p=926\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fighting antibiotic resistant bacteria by skipping anitbiotics - Nallathamby Laboratory\" \/>\n<meta property=\"og:description\" content=\"Phage-mimicking antibacterial core\u2013shell nanoparticles. Excited to have started publishing and filing for a patent on our antibiotic-free antimicrobial nanoparticles research. More to come in the following months! Thankful for the support from #notredame #ideacenter #antibioticresistance #ndnano #Advanceddiagnosticsandtherapeutics #ADandT #openaccess The increasing frequency of nosocomial infections caused by antibiotic-resistant microorganisms concurrent with the stagnant discovery of &hellip; Continue reading &raquo;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.nd.edu\/pdnano\/?p=926\" \/>\n<meta property=\"og:site_name\" content=\"Nallathamby Laboratory\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/prakashdn\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-08T16:17:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-10T21:14:23+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png\" \/>\n<meta name=\"author\" content=\"Prakash\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:site\" content=\"@prakashdn\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Prakash\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926\"},\"author\":{\"name\":\"Prakash\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"headline\":\"Fighting antibiotic resistant bacteria by skipping anitbiotics\",\"datePublished\":\"2019-11-08T16:17:23+00:00\",\"dateModified\":\"2024-01-10T21:14:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926\"},\"wordCount\":277,\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/11\\\/graphical-abstract-300x150.png\",\"articleSection\":[\"antibiotics\",\"Antimicrobial\",\"Berthiaume Institute for Precision Health\",\"multidrug resistance\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926\",\"name\":\"Fighting antibiotic resistant bacteria by skipping anitbiotics - Nallathamby Laboratory\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/11\\\/graphical-abstract-300x150.png\",\"datePublished\":\"2019-11-08T16:17:23+00:00\",\"dateModified\":\"2024-01-10T21:14:23+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926#primaryimage\",\"url\":\"http:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/11\\\/graphical-abstract-300x150.png\",\"contentUrl\":\"http:\\\/\\\/sites.nd.edu\\\/pdnano\\\/files\\\/2019\\\/11\\\/graphical-abstract-300x150.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?p=926#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Fighting antibiotic resistant bacteria by skipping anitbiotics\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#website\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/\",\"name\":\"Modular Nanotechnologies and Nanomaterials\",\"description\":\"Modular and scalable nanotechnology for imaging, sensing and therapeutics\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/#\\\/schema\\\/person\\\/3bec2d9fbd957b23abd53a0a5445b4f0\",\"name\":\"Prakash\",\"url\":\"https:\\\/\\\/sites.nd.edu\\\/pdnano\\\/?author=2672\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fighting antibiotic resistant bacteria by skipping anitbiotics - Nallathamby Laboratory","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.nd.edu\/pdnano\/?p=926","og_locale":"en_US","og_type":"article","og_title":"Fighting antibiotic resistant bacteria by skipping anitbiotics - Nallathamby Laboratory","og_description":"Phage-mimicking antibacterial core\u2013shell nanoparticles. Excited to have started publishing and filing for a patent on our antibiotic-free antimicrobial nanoparticles research. More to come in the following months! Thankful for the support from #notredame #ideacenter #antibioticresistance #ndnano #Advanceddiagnosticsandtherapeutics #ADandT #openaccess The increasing frequency of nosocomial infections caused by antibiotic-resistant microorganisms concurrent with the stagnant discovery of &hellip; Continue reading &raquo;","og_url":"https:\/\/sites.nd.edu\/pdnano\/?p=926","og_site_name":"Nallathamby Laboratory","article_publisher":"https:\/\/www.facebook.com\/prakashdn","article_published_time":"2019-11-08T16:17:23+00:00","article_modified_time":"2024-01-10T21:14:23+00:00","og_image":[{"url":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png","type":"","width":"","height":""}],"author":"Prakash","twitter_card":"summary_large_image","twitter_creator":"@prakashdn","twitter_site":"@prakashdn","twitter_misc":{"Written by":"Prakash","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926#article","isPartOf":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926"},"author":{"name":"Prakash","@id":"https:\/\/sites.nd.edu\/pdnano\/#\/schema\/person\/3bec2d9fbd957b23abd53a0a5445b4f0"},"headline":"Fighting antibiotic resistant bacteria by skipping anitbiotics","datePublished":"2019-11-08T16:17:23+00:00","dateModified":"2024-01-10T21:14:23+00:00","mainEntityOfPage":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926"},"wordCount":277,"image":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926#primaryimage"},"thumbnailUrl":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png","articleSection":["antibiotics","Antimicrobial","Berthiaume Institute for Precision Health","multidrug resistance"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926","url":"https:\/\/sites.nd.edu\/pdnano\/?p=926","name":"Fighting antibiotic resistant bacteria by skipping anitbiotics - Nallathamby Laboratory","isPartOf":{"@id":"https:\/\/sites.nd.edu\/pdnano\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926#primaryimage"},"image":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926#primaryimage"},"thumbnailUrl":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png","datePublished":"2019-11-08T16:17:23+00:00","dateModified":"2024-01-10T21:14:23+00:00","author":{"@id":"https:\/\/sites.nd.edu\/pdnano\/#\/schema\/person\/3bec2d9fbd957b23abd53a0a5445b4f0"},"breadcrumb":{"@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.nd.edu\/pdnano\/?p=926"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926#primaryimage","url":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png","contentUrl":"http:\/\/sites.nd.edu\/pdnano\/files\/2019\/11\/graphical-abstract-300x150.png"},{"@type":"BreadcrumbList","@id":"https:\/\/sites.nd.edu\/pdnano\/?p=926#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.nd.edu\/pdnano\/"},{"@type":"ListItem","position":2,"name":"Fighting antibiotic resistant bacteria by skipping anitbiotics"}]},{"@type":"WebSite","@id":"https:\/\/sites.nd.edu\/pdnano\/#website","url":"https:\/\/sites.nd.edu\/pdnano\/","name":"Modular Nanotechnologies and Nanomaterials","description":"Modular and scalable nanotechnology for imaging, sensing and therapeutics","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.nd.edu\/pdnano\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/sites.nd.edu\/pdnano\/#\/schema\/person\/3bec2d9fbd957b23abd53a0a5445b4f0","name":"Prakash","url":"https:\/\/sites.nd.edu\/pdnano\/?author=2672"}]}},"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts\/926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/users\/2672"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=926"}],"version-history":[{"count":5,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts\/926\/revisions"}],"predecessor-version":[{"id":970,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=\/wp\/v2\/posts\/926\/revisions\/970"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.nd.edu\/pdnano\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}