{"id":382,"date":"2021-06-14T22:00:07","date_gmt":"2021-06-15T02:00:07","guid":{"rendered":"https:\/\/sites.nd.edu\/peasleelab\/?page_id=382"},"modified":"2021-07-07T12:04:44","modified_gmt":"2021-07-07T16:04:44","slug":"blood","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/peasleelab\/research-projects\/total-fluorine-screening\/blood\/","title":{"rendered":"Blood"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><strong>Developing a Faster Method to Measure PFAS in Human Blood<\/strong><\/h1>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link\" href=\"https:\/\/sites.nd.edu\/peasleelab\/students\/yukun-j\/\" style=\"border-radius:4px\">Written by Yukun J.<\/a><\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<p>Most PFAS have properties of both hydrophobicity and hydrophily, and thus they have been <em>widely used in industrial and commercial applications, such as stain- and water-repellent products<\/em>. It has been found that PFAS are highly persistent in the environment, and they can also bioaccumulate and biomagnify in organisms. According to previous studies, PFAS have been found in marine food web and land animals, including the human body.&nbsp;<strong>PFAS has been identified in human blood, serum, urine, breast milk, placentae, and fetal organs<\/strong>, which has raised many concerns, because <strong>PFAS can cause various human health hazards such as developmental disorders and delays, liver damage, kidney and testicular cancer, thyroid disease, and immunosuppression.<\/strong><\/p>\n\n\n\n<pre class=\"wp-block-verse\">According to the National Health and Nutrition Examination Survey (NHANES) 2003-2017, all human blood in North America is estimated to have 5 ppb of PFAS.<\/pre>\n\n\n\n<p>There is a significant barrier to study human health effects related to PFAS exposure, due to the difficulties with measuring PFAS concentrations in blood in the current methodologies. There are <em>only four commercial labs in North America offering blood testing services<\/em>, each <strong>sample costs about $800<\/strong> to analyze, results are not available in less than <strong>5 to 6 weeks<\/strong> after the test, and only <strong>10 or fewer individual PFAS types<\/strong> are typically screened for. Thus, the detection of PFAS in human blood is <em>not easily accessible and is rarely done, so the true <\/em><strong>impacts of these chemicals on human health is largely unknown<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Project Goal<\/h2>\n\n\n\n<p>The goal of this project is to design and develop a <strong>cheap, fast, and more efficient method of detecting total PFAS in human blood<\/strong> by using activated carbon felts&#8211;for PFAS capture&#8211;and particle-induced gamma-ray emission (PIGE)&#8211;for rapidly screening and measurement.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Developing a Faster Method to Measure PFAS in Human Blood Most PFAS have properties of both hydrophobicity and hydrophily, and thus they have been widely used in industrial and commercial applications, such as stain- and water-repellent products. It has been found that PFAS are highly persistent in the environment, and they can also bioaccumulate and &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/sites.nd.edu\/peasleelab\/research-projects\/total-fluorine-screening\/blood\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Blood&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3956,"featured_media":0,"parent":85,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-382","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/pages\/382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/users\/3956"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/comments?post=382"}],"version-history":[{"count":8,"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/pages\/382\/revisions"}],"predecessor-version":[{"id":587,"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/pages\/382\/revisions\/587"}],"up":[{"embeddable":true,"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/pages\/85"}],"wp:attachment":[{"href":"https:\/\/sites.nd.edu\/peasleelab\/wp-json\/wp\/v2\/media?parent=382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}