{"id":12,"date":"2018-07-21T18:43:27","date_gmt":"2018-07-21T22:43:27","guid":{"rendered":"http:\/\/sites.nd.edu\/whitelab\/?page_id=12"},"modified":"2025-07-28T17:30:27","modified_gmt":"2025-07-28T21:30:27","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.nd.edu\/whitelab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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Italics indicates ND trainee.
*= Equal Contributions<\/em><\/p>\n\n\n\n

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  1. Czowski BJ, Marchi AN, <\/em>White KA<\/strong>. <\/em>Intracellular pH regulates \u03b2-catenin with low pHi increasing adhesion and signaling functions. BiorXiv, 2025.<\/em> Preprint, in revision: DOI: 10.1101\/2024.03.22.586349<\/a>.<\/em>
    <\/li>\n\n\n\n
  2. Lund LM, Marchi AN, Moremen R, <\/em>Alderfer L, Hall E, Hammer J, Asilebo IC, Trull<\/em> KJ,<\/em> Hanjaya-Putra D and <\/em>White KA<\/strong>. Intracellular pH dynamics respond to extracellular matrix stiffening and mediate vasculogenic mimicry through \u03b2-catenin. Cell Death & Disease<\/em>, in press <\/em>(2025). <\/em>Preprint: 10.1101\/2024.06.04.597454<\/a> <\/em>
    <\/li>\n\n\n\n
  3. Van Dyck PK<\/em>, Piszkin L, Gorski EA<\/em>, Tartarella Nascimento E<\/em>, Abebe JA<\/em>, Hoffmann L<\/em>, Peng J, White, KA<\/strong>. Ionizable networks mediate pH-dependent allostery in SH2 signaling proteins. Science Signaling, in press<\/em> (2025). <\/em>Preprint: 10.1101\/2024.08.21.608875<\/a>
    <\/li>\n\n\n\n
  4. Romero Moreno R<\/em>*, Czowski BJ*, Harris L, Kuehn JF, <\/em>White KA<\/strong>. <\/em>Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells. Journal of Biological Chemistry, 300(10): 107658 <\/em>(2024). PMID: 39128712<\/a>
    <\/li>\n\n\n\n
  5. Albalawy WN, Youm EB, Shipman KE, Trull KJ, <\/em>Baty CJ, Long KR, Rbaibi Y, Wang XP, Fagunloye OG, White KA<\/strong>, Jurczak MJ, Kashlan OB, Weisz OA. SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal <\/em>tubule fluid transport and albumin uptake. American Journal of Physiology-Renal,<\/em> 326(6): F1041-53 <\/em>(2024). PMID: 38660713<\/a>
    <\/li>\n\n\n\n
  6. Spear JS<\/em>, White KA.<\/strong> Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition. J Cell Sci<\/em>\u00a0136 (10): jcs261308. (2023) PMID: 37133398.<\/a>
    <\/li>\n\n\n\n
  7. Donahue CET<\/em>, Siroky MD<\/em>, White KA<\/strong>. An optogenetic tool to raise intracellular pH in single cells and drive localized membrane dynamics. JACS<\/em>, 143(45):18877-18887 (2021). <\/span>PMID: 34726911<\/a>.
    <\/li>\n\n\n\n
  8. Sesanto R*, Kuehn JF<\/em>*, Barber DL, <\/span>White KA<\/strong>. Low pH facilitates heterodimerization of mutant isocitrate dehydrogenase IDH1-R132H and promotes production of 2-hydroxyglutarate. <\/span>Biochemistry, <\/em>60, 25, 1983\u20131994. (2021) PMID: 34143606<\/a>.\u00a0 <\/span>
    <\/li>\n\n\n\n

  9. Luna, LA, Lesecq Z, <\/span>White KA,<\/strong> Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, IsomDG, Sohl CD. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. <\/span>Biochem J <\/em>477(16):2999-3018 (2020) <\/span>PMID: 32729927<\/a>. <\/span><\/p><\/li>\n<\/ol>\n\n\n\n

    Reviews\/Perspectives <\/span><\/h5>\n\n\n\n
      \n
    1. Czowski BJ*, Romero-Moreno R*, Trull KJ*,<\/em> <\/span>White KA<\/strong>. “Cancer and pH dynamics: Transcriptional regulation, proteostasis, and the need for new molecular tools.” <\/span>Cancers,<\/em> 12(10) 2760 (2020) <\/span>PMID: 32992762<\/a> [<\/span>PDF<\/a>]<\/span>
      <\/li>\n\n\n\n
    2. White KA<\/strong>, Kisor K, Barber DL. “Intracellular pH dynamics and charge-changing somatic mutations in cancer” <\/span>Cancer Metastasis Rev<\/em>, E-pub DOI: 10.1007\/s10555-019-09791-8 (2019) <\/span>PMID: 30982102 <\/a>[<\/span>PDF<\/a>]<\/span> <\/li>\n<\/ol>\n\n\n\n
      Pre-Notre Dame Publications:<\/span><\/h5>\n\n\n\n
        \n
      1. White KA*<\/strong>, Grillo-Hill BK*, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL. “\u00df-catenin is a pH sensor with decreased stability at higher intracellular pH.” <\/span>JCB<\/em>, 217(11) 3965-78 (2018) <\/span>PMID: 30315137 <\/a> <\/span><\/li>\n\n\n\n
      2. White KA<\/strong>, Garrido Ruiz D, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber DL. “Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.” <\/span>Sci. Signaling,<\/em> 10:eaam9931 (2017) <\/span>PMID: 28874603<\/a> <\/li>\n\n\n\n
      3. Vercoulen Y*, Kondo Y*, Iwig JS*, Janssen A, White KA<\/strong>, Amini M, Barber DL, Kuriyan J, Roose JP. “A histidine pH sensor regulates the activation of the Ras-specific guanidine nucleotide exchange factor RasGRP1.” <\/span>eLife, <\/em>6:e29002 (2017) <\/span>PMID: 28952923<\/a> <\/span> <\/li>\n\n\n\n
      4. Szpiech ZA, Strauli NB, White KA<\/strong>, Garrido Ruiz D, Jacobson MP, Barber DL, Hernandez RD. “Prominent features of the amino acid mutation landscape cancer.” <\/span>PLoS One<\/em>, 12(8):e0183273 (2017) <\/span>PMID: 28837668<\/a> <\/li>\n\n\n\n
      5. White KA<\/strong>, Grillo-Hill BK, Barber DL. “Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.” <\/span>J. Cell Sci., <\/em>130:663-669 (2017) <\/span>PMID: 28202602<\/a> <\/li>\n\n\n\n
      6. Webb BA, White KA<\/strong>, Grillo-Hill BK, Schonichen A, Choi CC, Barber DL. “A histidine cluster in the cytoplasmic domain of the Na-H exchanger NHE1 confers pH-sensitive PIP2 binding and regulates transporter activity.” <\/span>JBC <\/em>291:24096-104 (2016) <\/span>PMID: 27650500<\/a> <\/li>\n\n\n\n
      7. White KA#<\/sup><\/strong>, Zegelbone PM. “Directed evolution of a probe ligase with activity in the secretory pathway and application to imaging intercellular protein-protein interactions.” <\/span>Biochemistry<\/em>, 21:3728-3739 (2013) <\/span>PMID: 23614685<\/a>  <\/span>
        #<\/sup><\/strong>Senior and corresponding author<\/span><\/span><\/li>\n\n\n\n
      8. Uttamapinant C, Sanchez MI, Liu DS, Yao JZ, White KA<\/strong>, Grecian S, Clark S, Gee KR, Ting AY. “Site specific protein labeling using PRIME and chelation-assisted click chemistry.” <\/span>Nature Protocols<\/em> 8 (8):1620-1634 (2013) <\/span>PMID: 23887180<\/a> <\/li>\n\n\n\n
      9. Liu DS, Loh KH, Lam SS, White KA<\/strong>, Ting AY. “Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation.” <\/span>PLoS One<\/em> 8(2):e52823 (2013) <\/span>PMID: 23457452<\/a> <\/strong> <\/li>\n\n\n\n
      10. Uttamapinant C*, White KA*<\/strong>, Baruah H*, Thompson S, Fern\u00e1ndez-Su\u00e1rez M, Puthenveetil S, Ting AY. “A fluorophore ligase for site-specific protein labeling inside living cells.” <\/span>PNAS<\/em>, 107:10914-10919 (2010) <\/span>PMID: 20534555<\/a>  <\/span><\/li>\n\n\n\n
      11. Puthenveetil S, Liu DS, White KA<\/strong>, Thompson S, Ting AY. “Yeast display evolution of a kinetically-efficient 13-amino acid substrate for lipoic acid ligase.” <\/span>JACS, <\/em>131:16430-8 (2009) <\/span>PMID: 19863063<\/a> <\/span><\/li>\n<\/ol>\n\n\n\n

         <\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

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