Publications

Italics indicates ND trainee.
*= Equal Contributions

  1. Czowski BJ, Marchi AN, White KA. Intracellular pH regulates β-catenin with low pHi increasing adhesion and signaling functions. BiorXiv, 2025. Preprint, in revision: DOI: 10.1101/2024.03.22.586349.
  2. Lund LM, Marchi AN, Moremen R, Alderfer L, Hall E, Hammer J, Asilebo IC, Trull KJ, Hanjaya-Putra D and White KA. Intracellular pH dynamics respond to extracellular matrix stiffening and mediate vasculogenic mimicry through β-catenin. Cell Death & Disease, in press (2025). Preprint: 10.1101/2024.06.04.597454
  3. Van Dyck PK, Piszkin L, Gorski EA, Tartarella Nascimento E, Abebe JA, Hoffmann L, Peng J, White, KA. Ionizable networks mediate pH-dependent allostery in SH2 signaling proteins. Science Signaling, in press (2025). Preprint: 10.1101/2024.08.21.608875
  4. Romero Moreno R*, Czowski BJ*, Harris L, Kuehn JF, White KA. Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells. Journal of Biological Chemistry, 300(10): 107658 (2024). PMID: 39128712
  5. Albalawy WN, Youm EB, Shipman KE, Trull KJ, Baty CJ, Long KR, Rbaibi Y, Wang XP, Fagunloye OG, White KA, Jurczak MJ, Kashlan OB, Weisz OA. SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake. American Journal of Physiology-Renal, 326(6): F1041-53 (2024). PMID: 38660713
  6. Spear JS, White KA. Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition. J Cell Sci 136 (10): jcs261308. (2023) PMID: 37133398.
  7. Donahue CET, Siroky MD, White KA. An optogenetic tool to raise intracellular pH in single cells and drive localized membrane dynamics. JACS, 143(45):18877-18887 (2021). PMID: 34726911.
  8. Sesanto R*, Kuehn JF*, Barber DL, White KA. Low pH facilitates heterodimerization of mutant isocitrate dehydrogenase IDH1-R132H and promotes production of 2-hydroxyglutarate. Biochemistry, 60, 25, 1983–1994. (2021) PMID: 34143606. 

  9. Luna, LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, IsomDG, Sohl CD. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. Biochem J 477(16):2999-3018 (2020) PMID: 32729927.

Reviews/Perspectives 
  1. Czowski BJ*, Romero-Moreno R*, Trull KJ*, White KA. “Cancer and pH dynamics: Transcriptional regulation, proteostasis, and the need for new molecular tools.” Cancers, 12(10) 2760 (2020) PMID: 32992762 [PDF]
  2. White KA, Kisor K, Barber DL. “Intracellular pH dynamics and charge-changing somatic mutations in cancer” Cancer Metastasis Rev, E-pub DOI: 10.1007/s10555-019-09791-8 (2019) PMID: 30982102 [PDF]
Pre-Notre Dame Publications:
  1. White KA*, Grillo-Hill BK*, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL. “ß-catenin is a pH sensor with decreased stability at higher intracellular pH.” JCB, 217(11) 3965-78 (2018) PMID: 30315137
  2. White KA, Garrido Ruiz D, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber DL. “Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.” Sci. Signaling, 10:eaam9931 (2017) PMID: 28874603
  3. Vercoulen Y*, Kondo Y*, Iwig JS*, Janssen A, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. “A histidine pH sensor regulates the activation of the Ras-specific guanidine nucleotide exchange factor RasGRP1.” eLife, 6:e29002 (2017) PMID: 28952923
  4. Szpiech ZA, Strauli NB, White KA, Garrido Ruiz D, Jacobson MP, Barber DL, Hernandez RD. “Prominent features of the amino acid mutation landscape cancer.” PLoS One, 12(8):e0183273 (2017) PMID: 28837668
  5. White KA, Grillo-Hill BK, Barber DL. “Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.” J. Cell Sci., 130:663-669 (2017) PMID: 28202602
  6. Webb BA, White KA, Grillo-Hill BK, Schonichen A, Choi CC, Barber DL. “A histidine cluster in the cytoplasmic domain of the Na-H exchanger NHE1 confers pH-sensitive PIP2 binding and regulates transporter activity.” JBC 291:24096-104 (2016) PMID: 27650500
  7. White KA#, Zegelbone PM. “Directed evolution of a probe ligase with activity in the secretory pathway and application to imaging intercellular protein-protein interactions.” Biochemistry, 21:3728-3739 (2013) PMID: 23614685 
    #Senior and corresponding author
  8. Uttamapinant C, Sanchez MI, Liu DS, Yao JZ, White KA, Grecian S, Clark S, Gee KR, Ting AY. “Site specific protein labeling using PRIME and chelation-assisted click chemistry.” Nature Protocols 8 (8):1620-1634 (2013) PMID: 23887180
  9. Liu DS, Loh KH, Lam SS, White KA, Ting AY. “Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation.” PLoS One 8(2):e52823 (2013) PMID: 23457452 
  10. Uttamapinant C*, White KA*, Baruah H*, Thompson S, Fernández-Suárez M, Puthenveetil S, Ting AY. “A fluorophore ligase for site-specific protein labeling inside living cells.” PNAS, 107:10914-10919 (2010) PMID: 20534555 
  11. Puthenveetil S, Liu DS, White KA, Thompson S, Ting AY. “Yeast display evolution of a kinetically-efficient 13-amino acid substrate for lipoic acid ligase.” JACS, 131:16430-8 (2009) PMID: 19863063