148. Borrel, A., Melander, C., and Fourches, D. Chemoinformatics Analysis of
Fluoroquinolones and Their Inhibition Potency Against Four Pathogens. Molecular Informatics, doi.org/10.1002/minf.202000215


147. Weig, A. W., Barlock, S. L., O’Connor, P. M.,  Marciano, O. M., Melander, R. J., and Melander, C. A Scaffold Hopping Strategy to Generate New Aryl-2-Amino Pyrimidine MRSA Biofilm Inhibitors. RSC Medicinal Chemistry. 2021, 12, 293-296. doi.org/10.1039/D0MD00238K


146. Sandala, J. L, Eichar, B. W., Kuo, L. G., Hahn, M. M., Basak, A. K.,  Huggins, W. M., Woolard, K., Melander, C., and  Gunn, J. S. A Dual-therapy Approach for the Treatment of Biofilm-mediated Salmonella Gallbladder Carriage. PLOS Pathogens, 2020, 16(12): e1009192. doi.org/10.1371/journal.ppat.1009192


145. Barker, W. T., Jania, L. A., Melander, R. J.,  Koller, B. H., and Melander, C. Eukaryotic Phosphatase Inhibitors Enhance Colistin Efficacy in Gram-negative Bacteria. Chemical Biology & Drug Design. 2020, 96 (5) 1180-1186. doi.org/10.1111/cbdd.13735


144. Melander, R. J., Basak, A. K., and Melander, C. Natural Products as Inspiration for the Development of Bacterial Antibiofilm Agents. Natural Product Reports. 2020, 37, 1454 – 1477. doi.org/10.1039/D0NP00022A


143. Mattingly, A. E.,  Cox, K. E., Smith, R., Melander, R. J., Ernst,  R. K., and Melander, C. Screening an Established Natural Product Library Identifies Secondary Metabolites that Potentiate Conventional Antibiotics. ACS Infectious Diseases. 2020, 6 (10) 2629–2640. doi.org/10.1021/acsinfecdis.0c00259


142. Rasapalli, S., Murphy, Z. F., Sammeta, V., Golen, J. A., Weig, A. W., Melander, R. J., Melander, C., Macha, P., Vasudev, M., C. Synthesis and Biofilm Inhibition Studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones. Bioorganic & Medicinal Chemistry Letters. 2020, 30 (23) 127550. doi.org/10.1016/j.bmcl.2020.127550


141. Hubble, V. B, Bartholomew, K., Weig, A. W., Brackett, S. M., Barlock, S. L., Mattingly, A. E., Nemeth, A. M., Melander, R. J., and Melander, C. Augmenting the Activity of Macrolide Adjuvants Against Acinetobacter baumannii. ACS Medicinal Chemistry Letters, 2020, 11 (9) 1723–1731. doi.org/10.1021/acsmedchemlett.0c00276


140. Zeiler, M. J., Melander, R. J.,  and Melander, C. Second Generation Meridianin Analogs Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin-Resistant Gram-Negative Bacteria to Colistin. ChemMedChem. 2020 15, (17) 1672-167 doi.org/10.1002/cmdc.202000438


139. Dettweiler, M., Melander, R. J., Porras, G., Risener, C., Marquez, L., Samarakoon, T., Melander, C., and Quave, C. L. A Clerodane Diterpene from Callicarpa americana Resensitizes Methicillin-Resistant Staphylococcus aureus to ß-Lactam Antibiotics. ACS Infectious Diseases. 2020, 6 (7) 1667–1673 doi.org/10.1021/acsinfecdis.0c00307


138. Brackett, S. M.,  Cox, K. E.,  Barlock, S. L.,  Huggins, W. M.,  Ackart, D. F.,  Bassaraba, R. J.,  Melander, R. J., and Melander, C. Meridianin D Analogues Possess Antibiofilm Activity Against Mycobacterium smegmatis. RSC Medicinal Chemistry. 2020, 11, 92-97 doi.org/10.1039/C9MD00466A


137. Nemeth, A. M., Basak, A. K., Weig, A. W., Marrujo, S. A., Barker, W. T., Jania, L. A., Hendricks, T. A., Sullivan, A. E., O’Connor, P. M., Melander, R. J., Koller, B. H., and Melander. C. Structure Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants. ChemMedChem. 2020, 15 (2) 210-218 doi.org/10.1002/cmdc.201900560


136. Yan, A., Huang, M., Melander, C., Kjellerup, B. Dispersal and Inhibition of Biofilms Associated with Infections.  Journal of Applied Microbiology. 2020, 128 (5) 1279-1288. doi.org/10.1111/jam.14491


135. Melander R.J., Melander C. Strategies for the Eradication of Biofilm-Based Bacterial Infections. Antibacterial Drug Discovery to Combat MDR. (Springer) 2019, 499-526 doi.org/10.1007/978-981-13-9871-1_22


134. Barker, W. T., Nemeth, A. M., Brackett, S. M., Basak, A. K., Chandler, C. E., Jania, L. A., Zuercher, W. J., Melander, R. J., Koller, B. H., Ernst, R. K. and Melander, C. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-negative Bacteria. ACS Infectious Diseases, 2019, 5, (10), 1764-1771 doi.org/10.1021/acsinfecdis.9b00212


133. Cox, K.E., and Melander, C. Antibiofilm Activity of Quinazoline Derivatives against Mycobacterium smegmatis. MedChemComm, 2019, 10, 1177-1179 doi.org/10.1039/C9MD00156E


132. Martin, S.E., Melander, R.J., Brackett, C.M., Scott, A.J., Chandler, C.E., Nguyen, C.M., Minrovic, B.M., Harrill, S.E., Ernst. R.K., Manoil, C., and Melander, C. Small Molecule Potentiation of Gram-positive Selective Antibiotics Against Acinetobacter baumannii. ACS Infectious Diseases, 2019, 5, (7), 1223-1230 doi.org/10.1021/acsinfecdis.9b00067


131. Minrovic, B.M., Hubble, V.B., Barker, W.T., Jania, L.A., Melander, R.J., Koller, B.H., and Melander, C. Second Generation Tryptamine Derivatives Potently Sensitize Colistin-Resistant Bacteria to Colistin. ACS Medicinal Chemistry Letters, 2019, 10 (5), 828-833. doi.org/10.1021/acsmedchemlett.9b00135


130. Barker, W.T., Chandler, C.E., Melander, R.J., Ernst, R.K., and Melander, C. Tryptamine Derivatives Disarm Colistin Resistance in Polymyxin-Resistant Gram-negative Bacteria. Bioorganic and Medicinal Chemistry, 2019, 27 (9), 1776-1788. doi.org/10.1016/j.bmc.2019.03.019


129. Nguyen, T.V., Minrovic, B.M., Melander, R.J., and Melander, C. Identification of Anti‐Mycobacterial Biofilm Agents Based on the 2‐Aminoimidazole Scaffold, ChemMedChem, 2019, 14 (9) 927-937. doi.org/10.1002/cmdc.201900033


128. Nguyen, T.V., Peszko, M.T., Melander, R.J., and Melander, C. Using 2-Aminobenzimidazole Derivatives to Inhibit Mycobacterium smegmatis Biofilm Formation, Med. Chem. Commun., 2019,10, 456-459. doi.org/10.1039/C9MD00025A


127. Hubble, V.B., Hubbard, B., Minrovic, B.M., Melander, R.J., and Melander, C. Using Small Molecule Adjuvants to Repurpose Azithromycin for Use Against Pseudomonas aeruginosa. ACS Infectious Diseases, 2019, 5 (1), 141-151. doi.org/10.1021/acsinfecdis.8b00288


126. Jeon, A.B., Ackart, D.F., Li, W., Jackson, M., Melander, R.J., Melander, C., Abramovitch, R.B., Chicco, A.J., Basaraba, R.J., Obregon-Henao, A. 2-Aminoimidazoles Collapse Mycobacterial Proton Motive Force and Block the Electron Transport Chain, Scientific Reports, 2019, 9 (1), 1513. doi.org/10.1038/s41598-018-38064-7


125. Huggins, W.M., Nguyen, T.V., Hahn, N.A., Baker, J.T., Kuo, L.G., Kaur, D., Melander, R.J., Gunn, J.S., and Melander, C. 2-Aminobenzimidazoles as Antibiofilm Agents Against Salmonella eterica Serovar Typhimurium. MedChemComm, 2018, 9 (9), 1547-1522. doi.org/10.1039/c8md00298c


124. Minrovic, B.M., Jung, D., Melander, R.J., and Melander, C. A New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumanii. ACS Infectious Diseases, 2018, 4 (9), 1368-1376. doi.org/10.1021/acsinfecdis.8b00103


123. Huggins, W.M., Barker, W.T., Baker, J.T., Hahn, N., Melander, R.J., and Melander, C. Meridianin D Analogues Display Antibiofilm Activity Against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria. ACS Medicinal Chemistry Letters, 2018, 9 (7), 702-707 doi.org/10.1021/acsmedchemlett.8b00161


122. Martin, S.E., Nguyen, C.M., Basaraba, R.J., and Melander, C. Analogue Synthesis Reveals Decoupling of Antibiofilm and ß-Lactam Potentiation Activities of a Lead 2-Aminoimidazole Adjuvant Against Mycobacterium smegmatis. Chemical Biology & Drug Design, 2018, 92 (3), 1403-1408. doi.org/10.1111/cbdd.13208


121. Milton, M.E., Minrovic, B.M., Harris, D., Kang, B., Jung, D., Lewis, C.P., Thompson, R.J., Melander, R. J., Zeng, D., Melander, C., and Cavanagh, J. Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp. Frontiers, 2018, 5, Article 15. doi.org/10.3389/fmolb.2018.00015


120. Melander, R.J., Zurawski, D.V., and Melander, C. Narrow-Spectrum Antibacterial Agents. (Invited review). MedChemComm, 2018, 9, 12-21. doi.org/10.1039/C7MD00528H


119. Robb, A.J., Vinogradov, S., Anderson, E., Blackledge, M.S. Melander, C., and Hvastkovs, E.G. Electrochemical Detection of Small Molecule Induced Biofilm Dispersion. Electrochemica Acta, 2018, 268, 276-282. doi.org/10.1016/j.electacta.2018.02.113


118. Barker, W. T., Martin, S.E., Chandler, C.E., Nguyen, T.V., Harris, T.L., Goodell, C., Melander, R.J., Doi, Y., Ernst, R. K., Melander, C. Small Molecule Adjuvants that Suppress Both Chromosomal and mcr-1 Encoded Colistin-Resistance and Amplify Colistin Efficacy in Polymyxin-Susceptible Bacteria. Bioorganic and Medicinal Chemistry, 2017, 25, 5749-5753. doi.org/10.1016/j.bmc.2017.08.055


117. Milton, M.E., Allen, C.L., Feldmann, E.A., Bobay, B.G., Stephens, M.D., Melander, R.J., Theisen, K.E., Zeng, D., Thopmson, R.J., Melander, C., Cavanagh, J. Structure of the Francisella Response Regulator QseB Receiver Domain, and Characterization of QseB Inhibition by Antibiofilm 2-Aminoimidazole-Based Compounds. Molecular Microbiology, 2017, 106, 223-235.  doi.org/10.1111/mmi.13759


116. Jeon, A.B., Obregon-Henao, A., Ackart, D.F., Podell, B.K., Belardinelli, J., Jackson, M., Nguyen, T.V., Blackledge, M.S., Melander, R.J., Melander, C., Johnson, B., Abramovitch, R., and Basaraba, R.J. 2-Aminoimidazoles Potentiate ß-Lactam Antimicrobial Activity against Mycobacterium tuberculosis by Reducing ß-Lactamase Secretion and Increasing Cell Wall Permeability. PLOS One, 2017, 12, e0180925. doi.org/10.1371/journal.pone.0180925


115. Byrne-Nash, R., Lucero, D.M., Osbaugh, N.A., Melander, R.J., Melander, C., and Feldheim, D.L. Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered Through Small Molecule Variable Ligand Display. Bioconjugate Chemistry, 2017, 28, 1807-1810. doi.org/10.1021/acs.bioconjchem.7b00199


114. Melander, R.J. and Melander, C. The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach. ACS Infectious Diseases, 2017, 3, 559-563. doi.org/10.1021/acsinfecdis.7b00071


113. Garcia, S.S., Blackledge, M.S., Michalek, S., Su, L., Ptacek, T., Eipers, P., Morrow, C., Lefkowitz, E.J., Melander, C., and Wu, H. Selective Targeting of Streptococcus mutans by a Novel Small Molecule Preserves the Oral Microbiome in vivo. Journal of Dental Research, 2017, 96, 807-814. doi.org/10.1177/0022034517698096


112. Melander, R.J., and Melander, C. Antibiotic Adjuvants. Topics in Medicinal Chemistry: Antibacterials (Springer). 2017, 25, 89-118. doi.org/10.1007/7355_2017_10


111. Nguyen, T.V., Blackledge, M.S., Lindsey, E.A., Minrovic, B.M., Ackart, D.F., Jeon, A.B., Obregon-Henao, A., Melander, R.J., Basaraba, R.J., and Melander, C. The Discovery of 2-Aminobenzimidazoles that Sensitize M. smegmatis and M. tuberculosis to ß-Lactam Antibiotics in a Pattern Distinct from ß-Lactamase Inhibitors. Angewandte Chemie, 2017, 56 (14), 3940-3944. doi.org/10.1002/anie.201612006


110. Draughn, C. L., Allen, C.L., Routh, P.A., Stone, M.R., Kirker, K.R., Schuchman, R.M., Linder, K.E., Baynes, R.E., Garth, J., Melander, C., Pollard, A., and Cavanagh, J. Evaluation of a 2-Aminoimidazole Variant as Adjuvant Treatment for Dermal Bacterial Infections. Drug Design, Development, and Therapy. 2017, 11, 153-162. doi.org/10.2147/DDDT.S111865


109. Huggins. W.M., Minrovic, B.M., Corey, B.W., Jacobs, A.C., Melander, R.J., Zurawski, D.V., and Melander, C. 1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics Against Multi-Drug Resistant Acinetobacter baumannii. ACS Medicinal Chemistry Letters, 2017, 8 (1), 27-31. doi.org/10.1021/acsmedchemlett.6b00296 


108. Corey, W., Thompson, M.G., Hittle, L.E., Jacobs, A.C., Asafo-Adjei, E.A., Dunn, T.M., Huggins, W.M., Melander, R.J., Melander, C., Ernst, R.K., and Zurawski, D.V. 1,2,4-Triazolidine-3-thiones Have Specific Activity Against Acinetobacter baumannii Amongst Common Nosocomial Pathogens. ACS Infectious Diseases, 2017, 3 (1), 62-71. doi.org/10.1021/acsinfecdis.6b00133


107. Melander, R.J. and Melander, C. Inhibitors of Biofilm Production. Antibiotic Drug Discovery: New Targets and Molecular Entities (The Royal Society of Chemistry). 2017, 43-75. doi.org/10.1039/9781782629870-00043


106. Stephens, M.D., Yodsanit, N., and Melander, C. Potentiation of the Fosmidomycin Analogue FR 900098 with Substituted 2-Oxazolines Against Francisella novicida. MedChemComm. 2016, 7, 1952-1956. doi.org/10.1039/C6MD00365F


105. Melander, R.J., Liu, H.-B., Stephens, M.D., Bewley, C.A., and Melander, C. Marine Sponge Alkaloids as a Source of Anti-Bacterial Adjuvants. Bioorganic and Medicinal Chemistry Letters, 2016, 26 (24), 5863-5866. doi.org/10.1016/j.bmcl.2016.11.018


104. Stephens, M.D., Yodsanit, N., and Melander, C. Analogues of the Natural Product Ethyl N-(2-Phenethyl) Carbamate as Potent Biofilm Inhibitors of Methicillin Resistant Staphylococcus aureus. Organic and Biomolecular Chemistry. 2016, 14, 6853 – 6856. doi.org/10.1039/c6ob00706f


103. Stephens, M.D., Hubble, V.B., Ernst, R.K., Melander, R.J., Cavanagh, J., and Melander, C. Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants. MedChemComm (Special Issue on Antibiotic Resistance). 2016, 7 (1), 128-131. doi.org/10.1039/C5MD00353A


102. Brackett, C.M., Furlani, R.E., Anderson, R.G., Krishnamurthy, A., Melander, R.J., Moskowitz, S.M., Ernst, R.K. and Melander, C. Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity. Tetrahedron (Special Issue on Antibiotic Resistance), 2016, 72 (25), 128-131. doi.org/10.1016/j.tet.2015.09.019


101. Pan, W., Fan, W., Wu, H., Melander, C., and Liu, C. A New Small Molecule Inhibits Streptococcus mutans Biofilms in vitro and in vivo. Journal of Applied Microbiology. 2015, 119 (5), 3406-3409. doi.org/10.1111/jam.12940


100. Furlani, R.E., Richardson, M.A., Podell, B.K., Ackart, D.F., Haugen, J.D., Melander, J.J., Basaraba, R.J., and Melander, C. Second Generation 2-Aminoimidazole Based Advanced Glycation End Product Inhibitors and Breakers. Bioorganic and Medicinal Chemistry Letters (25th anniversary). 2015, 25 (21), 4820-4823. doi.org/10.1016/j.bmcl.2015.06.080


99. Garrido, C., Simpson, C.A., Dahl, N.P., Bresee, J., Whitehead, D.C., Lindsey, E.A., Harris, T.L., Smith, C.A., Carter, C.J., Feldheim, D.L., Melander, C, and Margolis, D.M. Gold Nanoparticles to Improve HIV Drug Delivery. Future Medicinal Chemistry, 2015, 7 (9), 1097-1107. doi.org/10.4155/fmc.15.57


98. Richardson, M.A., Furlani, R.E., Podell, B.K., Ackart, D.F., Haugen, J.D., Melander, R.J., Melander, C., and Basaraba, R.J. Inhibition and Breaking of Advanced Glycation End-Products with Bis-2-Aminoimidazole Derivatives. Tetrahedron Letters, 2015, 56 (23), 3406-3409. doi.org/10.1016/j.tetlet.2015.01.122


97. Melander, R.J., and Melander, C. From Worms to Targeting Virulence Factors (Invited Commentary). Chemistry and Biology, 2015, 22 (4), 436-437. doi.org/10.1016/j.chembiol.2015.04.005


96. Stowe, S.D., Thompson, R.J., Peng, L., Su, Z., Blackledge, M.S., Draughn G.L., Coe, W.H., Johannes, E., Lapham, V.K., Mackenzie, J., Melander, C., and Cavanagh, J. Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Gram-Negative Pathogen, Acinetobacter baumannii. Current Drug Delivery, 2015, 12 (2), 223-30. doi.org/10.2174/1567201811666140924125740


95. Wahome, P.G., Beauchesne, K.R., Cato-Pedone, A., Cavanagh, C., Melander, C., Zimba, P., and Moeller, P.D.R. Augmenting Anti-Cancer Natural Products with a Small Molecule Adjuvant. Marine Drugs, 2015, 13 (1), 65-75. doi.org/10.3390/md13010065


94. Melander, R.J. and Melander, C. Innovative Strategies for Combating Biofilm-based Infections Biofilm-based Healthcare-associated Infections (Springer). 2015, 831, 69-91. doi.org/10.1007/978-3-319-09782-4_6


93. Gifford, J.C., Bresee, J., Carter, C.J., Wang, G., Melander, R., Melander, C., and Feldheim, D.L. Thiol-Modified Gold Nanoparticles for the Inhibition of M. smegmatis. Chemical Communications, 2014, 50 (100), 15860-15863. doi.org/10.1039/c4cc06236a


92. Brackett, C.M., Melander, R.J., An, I.H., Krisnamurthy, A., Thompson, R.J., Cavanagh, J., and Melander, C. Small Molecule Suppression of ß-Lactam Resistance in Multi-drug Resistant Gram-negative Pathogens. Journal of Medicinal Chemistry, 2014, 57 (17), 7450-7458. doi.org/10.1021/jm501050e


91. Wright, C.J., Wu, H., Melander, R.J., Melander, C, and Lamont, R.J. Disruption of Heterotypic Community Development by Porphyromonas gingivalis with Small Molecule Inhibitors. Molecular Oral Microbiology, 2014, 29 (5), 185-193. doi.org/10.1111/omi.12060


90. Melander, R.J., Minvielle, M.J., and Melander, C. Controlling Bacterial Behavior with Indole-containing Natural Products and Derivatives (invited review). Tetrahedron, 2014, 70 (37), 6363-6372. doi.org/10.1016/j.tet.2014.05.089


89. Bresee, J., Bond, C.M., Worthington, R.J., Smith, C.A., Carter, C.J., Simpson, C.A., Wang, G., Hartman, J., Osbaugh, N.A., Melander, C., and Feldheim, D.L. Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics. Journal of the American Chemical Society, 2014, 136 (14), 5295-5300. doi.org/10.1021/ja408505n


88. Ackart, D.F., Lindsey, E.A., Podell, B.K., Melander, R.J., Basaraba, R.J., and Melander, C. Reversal of Mycobacterium tuberculosis Phenotypic Drug Resistance by 2-Aminoimidazole Based Small Molecules. FEMS Pathogens and Disease, 2014, 70 (3), 370-378. doi.org/10.1111/2049-632X.12143


87. Ackart, D.F., Parks, Q.M., Kirk, N.M., Podell, B.K., Melander, C., Orme, I.M., Leid, J.G., Nick, J.A., and Basaraba, R.J. Expression of Antimicrobial Drug Tolerance by Attached Communities of Mycobacterium tuberculosis. FEMS Pathogens and Disease, 2014, 70 (3), 359-369. doi.org/10.1111/2049-632X.12144


86. Worthington, R.J, Richards, J.J., and Melander, C. Non-Microbicidal Control of Bacterial Biofilms with Small Molecules. Anti-Infective Agents, 2014, 12 (1), 120-38. doi.org/10.2174/22113525113119990107


85. Harris, T.L., Worthington, R.J., Hittle, L.E., Zurawski, D.V., Ernst, R.K., and Melander, C. Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance. ACS Chemical Biology, 2014, 9 (1), 127-7. doi.org/10.1021/cb400490k


84. Minvielle, M.J., Eguren, K., and Melander, C. Highly Active Modulators of Indole Signaling to Alter Pathogenic Behavior in Gram-Negative and Gram-Positive Bacteria. Chemistry: A European Journal, 2013, 19 (51), 17595-602. doi.org/10.1002/chem.201303510


83. Blackledge, M.S., Worthington, R.J., and Melander, C. Biologically-Inspired Strategies for Combating Bacterial Biofilms. Current Opinion in Pharmacology, 2013, 13 (5), 699-706. doi.org/10.1016/j.coph.2013.07.004


82. Minvielle, M.J., Bunders, C.A., and Melander, C. Indole/triazole Conjugates are Selective Inhibitors and Inducers of Bacterial Biofilms. MedChemComm, 2013, 4 (6), 916-919. doi.org/10.1039/C3MD00064H


81. Worthington, R.J. and Melander, C. Overcoming Resistance to β-Lactam Antibiotics (JOCSynopsis). Journal of Organic Chemistry, 2013, 78 (9), 4207-4213. doi.org/10.1021/jo400236f


80. Blackledge, M.S. and Melander, C. Programmable DNA-binding Small Molecules. Bioorganic and Medicinal Chemistry, 2013, 21 (20), 6101-14. doi.org/10.1016/j.bmc.2013.04.023


79. Worthington, R.J., Blackledge, M.S., and Melander, C. Small Molecule Inhibition of Bacterial Two-Component Systems to Combat Antibiotic Resistance and Virulence. Future Medicinal Chemistry, 2013, 5 (11), 1265-1284. doi.org/10.4155/fmc.13.58


78. Worthington, R.J. and Melander, C. Combination Approaches to Combat Multi-Drug Resistant Bacteria. Trends in Biotechnology, 2013, 31 (3), 177-184. doi.org/10.1016/j.tibtech.2012.12.006


77. Furlani, R., Yeagley, A.A., and Melander, C. A Flexible Approach to 1,4-Disubstituted 2-Aminoimidazoles that Inhibit and Disperse Biofilms and Potetiate the Effects of β-Lactams against Multi-Drug Resistant Bacteria. European Journal of Medicinal Chemistry, 2013, 62, 59-70. doi.org/10.1016/j.ejmech.2012.12.005


76. Yeagley, A.A., Su, Z., McCullough, K., Worthington, R. J., and Melander, C. N-Substituted 2-Aminoimidazole Inhibitors of MRSA Biofilm Formation Accessed Through Direct 1,3-Bis(tert-butoxycarbonyl)guanidine Cyclization. Organic and Biomolecular Chemistry, 2013, 11 (1), 130-137. doi.org/10.1039/C2OB26469B


75. Thompson, R.J., Bobay, B.G., Stowe, S.D., Peng, L. Su, Z., Actis, L.A., Melander, C., and Cavanagh, J. Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Anti-Biofilm Agent. Biochemistry, 2012, 51 (49), 9776-9778. doi.org/10.1021/bi3015289


74. Harris, T.L., Worthington, R.J., and Melander, C. Potent Small Molecule Suppression of Oxacillin Resistance in methicillin-resistant Staphylococcus aureus. Angewandte Chemie, 2012, 51 (45), 11254-11257. doi.org/10.1002/anie.201206911


73. Lindsey, E.A., Brackett, C.M., Mullikin, T., Alcaraz, C., and Melander, C. The Discovery of N-1 Substituted 2-Aminobenzimidazoles as Zinc-Dependent S. aureus Biofilm Inhibitors. MedChemComm, 2012, 3 (11), 1462-1465. doi.org/10.1039/C2MD20244A


72. Su, Z., Yeagley, A.A., Su, R., Peng, L., and Melander, C. Structural Studies on 4,5-Disubstituted-2-Aminoimidazole-Based Biofilm Modulators that Suppress Bacterial Resistance to β-Lactams. ChemMedChem, 2012, 7 (11), 2030-2039. doi.org/10.1002/cmdc.201200350


71. Melander, C and Margolis, D.M. Forcing an Enemy into the Open. Nature Chemistry, 2012, 4 (9), 692-693. doi.org/10.1038/nchem.1444


70. Olson, A.L., Thompson, R.J., Melander, C., and Cavanagh, J. Chemical Shift Assignments and Secondary Structure Prediction of the C-Terminal Domain of the Response Regulator BfmR from Acinetobacter baumannii. Journal of Biomolecular NMR, 2012, 6 (1), 95-8. doi.org/10.1007/s12104-012-9454-2


69. Worthington, R.J. and Melander, C. Deconvoluting Interspecies Bacterial Communication. Angewandte Chemie, 2012, 51 (26), 6314-6315. doi.org/10.1002/anie.201202440


68. Worthington, R.J., Richards, J.J., and Melander, C. Small Molecule Control of Bacterial Biofilms, Organic and Biomolecular Chemistry, 2012, 10 (37), 7457 – 7474. doi.org/10.1039/c2ob25835h


67. Worthington, R.J., Rogers, S.A., Huigens, R.W., Melander, C., and Ritchie, D.F. Foliar Applied Small Molecule That Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Peppers. Plant Disease, 2012 96 (11), 1638-1644. doi.org/10.1094/PDIS-02-12-0190-RE


66. Worthington, R.J., Bunders, C.A., Reed, C.S., and Melander, C. Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella penumoniae. ACS Medicinal Chemistry Letters, 2012 3 (5), 357-361. doi.org/10.1021/ml200290p


65. Lindsey, E.A., Worthington, R.J., Alcaraz, C., and Melander, C. 2-Aminopyrimidine as a Novel Scaffold for Biofilm Modulation. Organic and Biomolecular Chemistry, 2012, 10 (13), 2552-2561. doi.org/10.1039/c2ob06871k


64. Su, Z., Peng, L., and Melander, C. A Modular Approach to the Synthesis of 1,4,5-Substituted-2-Aminoimidazoles. Tetrahedron Letters, 2012, 53 (10), 1204-1206. doi.org/10.1016/j.tetlet.2011.12.090


63. Budhathoki-Uprety, J., Peng, L., Melander, C., and Novak, B.M. Synthesis of Guanidinium Functionalized Polycarbodiimides and their Antibacterial Activities. ACS Macro Letters, 2012 1 (3), 370-374. doi.org/10.1021/mz200116k


62. Olson, A.L., Bobay, B.G., Melander, C, and Cavanagh, J. 1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. Biomolecular NMR Assignments, 20126(1), 95-98. doi.org/10.1007/s12104-011-9333-2


61. Stowe, S.D., Tucker, A.T, Rogers, S.A., Richards, J.J., Melander, C., and Cavanagh, J. Evaluation of the Toxicity of  2-Aminoimidazole Antibiofilm Agents using both Cellular and Model Organism Systems. Drug and Chemical Toxicology, 201235 (3), 310-315. doi.org/10.3109/01480545.2011.614620


60. Bunders, C.A., Minvielle, M.J., Worthington, R.J., Ortiz, M., Cavanagh, J., and Melander, C. Intercepting Bacterial Indole Signaling with Flustramine Derivatives. Journal of the American Chemical Society, 2011, 133 (50), 20160-20163. doi.org/10.1021/ja209836z


59. Stowe, S.D., Richards, J.J., Tucker, A.T., Thompson, R., Melander, C, and Cavanagh, J. Anti-Biofilm Compounds Derived from Marine Sponges. Marine Drugs, 2011, 9 (11), 2010-2035. doi.org/10.3390/md9102010


58. Su, Z., Peng, L., Worthington, R.J., and Melander, C. Evaluation of 4,5-Disubstituted-2-Aminoimidazoles for Dual Antibiofilm/Antibiotic Resensitization Activity. ChemMedChem, 2011, 6, 2243-2251. doi.org/10.1002/cmdc.201100316


57. Harris, T., Worthington, R.J., and Melander, C. A Facile Synthesis of 1,5-Disubstituted-2-Aminoimidazoles: Antibiotic and Antibiofilm Activity of a First Generation Library. Bioorganic and Medicinal Chemistry Letters, 2011, 21 (15), 4516-4519. doi.org/10.1016/j.bmcl.2011.05.123


56. Bunders, C.A., Cavanagh, J., and Melander, C. Flustramine Inspired Synthesis and Biological Evaluation of Pyrroloindoline Triazole Amides as Novel Inhibitors of Bacterial Biofilms. Organic and Biomolecular Chemistry, 2011, 9, 5476-5481. doi.org/10.1039/c1ob05605k


55. Bresee, J., Maier, K.E., Boncella, A.E., Melander, C., and Feldheim, D.L. Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles. Small, 2011, 7 (14), 2027-2031. doi.org/10.1002/smll.201100420


54. Peng, L., DeSousa, J., Su, Z., Novak, B.M., Nevzorov, A.A., Garland, E.R., and Melander, C. Inhibition of Acinetobacter baumannii Biofilm Formation on a Methacrylate Polymer Containing a 2-Aminoimidazole Subunit. Chemical Communications, 2011, 47 (17), 4896-4898. doi.org/10.1039/C1CC10691K


53. Liu, C., Worthington, R.J., Melander, C., and Wu, H. A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms. Antimicrobial Agents and Chemotherapy, 2011, 55(6), 2679-2687. doi.org/10.1128/AAC.01496-10


52. Rogers, S.A., Lindsey, E.A, Whitehead, D.C., Mullikin, T. and Melander, C. Synthesis and Biological Evaluation of 2-Aminoimidazole/Carbamate Hybrid Anti-biofilm and Antimicrobial Agents. Bioorganic and Medicinal Chemistry Letters, 2011, 21 (4), 1257-1260. doi.org/10.1016/j.bmcl.2010.12.057


51. Reyes, S., Huigens, R.W., Su, Z., Simon, M.L., and Melander, C. Synthesis and Biological Activity of 2-Aminoimidazole Triazoles Accessed by Suzuki-Miyaura Cross-Coupling, Organic and Biomolecular Chemistry, 2011, 9(8), 3041-3049. doi.org/10.1039/C0OB00925C


50. Bresee, J., Maier, K.E., Melander, C., and Feldheim, D.L. Identification of Antibiotics Using Small Molecule Variable Ligand Display on Gold Nanoparticles, Chemical Communications, 2010, 46 (40), 7516-7518. doi.org/10.1039/C0CC02663H


49. Reed, C.S., Huigens, R.W., Rogers, S.A., and Melander, C. Modulating the Development of E. coli Biofilms with 2-Aminoimidazoles, Bioorganic and Medicinal Chemistry Letters, 2010, 20 (21), 6310-6312. doi.org/10.1016/j.bmcl.2010.08.075


48. Rogers, S.A., Whitehead, D.C., Mullikin, T., and Melander, C. Synthesis and Bacterial Biofilm Inhibition Studies of Ethyl N-(2-Phenethyl) Carbamate Derivatives. Organic and Biomolecular Chemistry, 2010, 8, 3857-3859. doi.org/10.1039/C0OB00063A


47. Bunders, C., Richards, J.J., and Melander, C. Identification of Aryl 2-Aminoimidazoles as Biofilm Inhibitors of Gram-Negative Bacteria. Bioorganic and Medicinal Chemistry Letters, 2010, 20 (12), 3797-3800. doi.org/10.1016/j.bmcl.2010.04.042


46. Su, Z., Rogers, S.A., McCall, W.S., Smith, A.C., Ravishankar, S., Mullikin, T., and Melander, C. A Nitroenolate Approach to the Synthesis of 4,5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity. Organic and Biomolecular Chemistry, 2010, 8(12), 2814-2822. doi.org/10.1039/C001479F


45. Rogers, S.A., Huigens, R.W., Cavanagh, J., and Melander, C. Synergistic Effects Between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents. Antimicrobial Agents and Chemotherapy, 2010, 54(5), 2112-2118. doi.org/10.1128/AAC.01418-09


44. Heinecke, C.L. and Melander, C. Analysis of Kinamycin D Mediated DNA Cleavage. Tetrahedron Letters, 2010, 51 (11), 1455-1458. doi.org/10.1016/j.tetlet.2009.12.142


43. Huigens, R.W., Reyes, S., Reed, C.S., Bunders, C., Rogers, S.A., Steinhauer, A.T., and Melander, C. The Chemical Synthesis and Antibiotic Activity of a Diverse Library of 2-Aminobenzimidazole Small Molecules Against MRSA and Multidrug-Resistant A. baumannii. Bioorganic and Medicinal Chemistry, 2010, 18 (2), 663-674. doi.org/10.1016/j.bmc.2009.12.003


42. Rogers, S.A., Bero, J.D., and Melander, C. Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents. ChemBioChem, 2010, 11 (3), 396-410. doi.org/10.1002/cbic.200900617


41. Richards, J.J. and Melander, C. Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance. Anti-Infective Agents in Medicinal Chemistry, 2009, 8, 295-314. doi.org/10.2174/187152109789760135


40. Richards, J.J. and Melander, C. Controlling Bacterial Biofilms. ChemBioChem, 2009, 10 (14), 2287-2294. doi.org/10.1002/cbic.200900317


39. Richards, J.J.; Reyes, S.; Stowe, S.D.; Tucker, A.T.; Ballard, T.E.; Cavanagh, J.; and Melander, C. Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity. Journal of Medicinal Chemistry, 2009, 52 (15), 4582-4585. doi.org/10.1021/jm900378s


38. Rogers, S.A., Huigens, R.W., and Melander, C. A 2-Aminobenzimidazole that Inhibits and Disperses Gram-Positive Biofilms Through a Zinc-Dependent Mechanism. Journal of the American Chemical Society, 2009, 131 (29), 9868–9869. doi.org/10.1021/ja9024676


37. Melander, C., Moeller, P.D.R., Ballard, T.E., Richards, J.J., Huigens, R.W., and Cavanagh, J. Evaluation of Dihydrooroidin as an Antifouling Additive in Marine Paint. International Biodeterioration & Biodegradation. 2009, 63, 529-532. doi.org/10.1016/j.ibiod.2008.08.009


36. Ballard, T.E., Richards, J.J., Aquino, A., Reed, C.S. and Melander, C. Anti-biofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation. Journal of Organic Chemistry, 2009, 74 (4), 1755-1758. doi.org/10.1021/jo802260t


35. Huigens, R.W., Rogers, S.A., Steinhauer, A.T., and Melander, C. Inhibition of Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa Biofilms with a Class of TAGE-Triazole Conjugates. Organic and Biomolecular Chemistry, 2009, 7 (4), 794-802. doi.org/10.1039/b817926c


34. Rogers, S.A., Krayer, M., Lindsey, J.S., and Melander, C. Tandem Dispersion and Killing of Bacteria from a Biofilm. Organic and Biomolecular Chemistry, 2009, 7 (3), 603-606. doi.org/10.1039/b817923a


33. Ballard, T. E., Richards, J.J., Wolfe, A.L., and Melander, C. Synthesis and Anti-biofilm Activity of a Second Generation Reverse Amide Oroidin Library: An SAR Study. Chemistry a European Journal, 2008, 14 (34), 10745-10761. doi.org/10.1002/chem.200801419


32. Richards, J.J., Reed, C.S., and Melander, C. Effects of N-Pyrrole Substitution on the Anti-Biofilm Activities of Oroidin Derivatives Against Acinetobacter baumannii. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (15), 4325-4327. doi.org/10.1016/j.bmcl.2008.06.089


31. Richards, J.J. and Melander, C. Synthesis of a 2-Aminoimidazole Library for Anti-Biofilm Screening Utilizing the Sonogashira Reaction. Journal of Organic Chemistry, 2008, 73 (13), 5191-5193. doi.org/10.1021/jo800618q


30. Rogers, S.A. and Melander, C. Construction and Screening of a 2-Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms Across Order, Class, and Phylum. Angewandte Chemie, 2008, 47 (28), 5229-5231. doi.org/10.1002/anie.200800862


29. Bowman, M.C., Ballard, T.E., Ackerson, C.J., Feldheim, D.J., Margolis, D.M., and Melander, C. Inhibition of HIV Fusion with Multivalent Gold Nanoparticles. Journal of the American Chemical Society, 2008, 130 (22), 6896-6897. doi.org/10.1021/ja710321g


28. Ballard, T.E. and Melander, C. Kinamycin-Mediated Cleavage of DNA under Biomimetic Conditions. Tetrahedron Letters. 2008, 49, 3157-3161. doi.org/10.1016/j.tetlet.2008.03.019


27. Richards, J.J., Ballard, T. E., Huigens, R.W., and Melander, C. Synthesis and Screening of an Oroidin Library Against Pseudomonas aeruginosa Biofilms. ChemBioChem 2008, 9 (8), 1267-1279.  doi.org/10.1002/cbic.200700774


26. Huigens, R.W., Ma, L., Gambino, C., Basso, A., Moeller, P.D.R., Cavanagh, J., Wozniak, D. J., and Melander, C. Control of Bacterial Biofilms with Marine Alkaloid Derivatives. Molecular BioSystems, 2008, 4 (6), 614-621. doi.org/10.1039/B719989A


25. Richards, J.J., Ballard, T.E., and Melander, C. Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms with Reverse Amide 2-Aminoimidazole Oroidin Analogues. Organic and Biomolecular Chemistry, 2008, 6 (8), 1356-1363. doi.org/10.1039/b719082d


24. Richards, J.J., Huigens, R.W., Ballard, T. E., Basso, A., Cavanagh, J., and Melander, C. Inhibition and Dispersion of Proteobacterial Biofilms. Chemical Communications, 2008, 14, 1698-1700. doi.org/10.1039/b719802g


23. Burns. V.A., Bobay, B.G., Basso, A., Cavanagh, J., and Melander, C. Targeting RNA with Cysteine-Constrained Peptides. Bioorganic & Medicinal Chemistry Letters, 2008, 18 (2), 565-567. doi.org/10.1016/j.bmcl.2007.11.096


22. Huigens, R.W., Richards, J. J., Parise, G.; Ballard, T.E., Zeng, W., Deora, R., Melander, C. Inhibition of Pseudomonas aeruginosa Biofilm Formation with Bromoageliferin Analogues. Journal of the American Chemical Society 2007, 129, (22), 6966-6967. doi.org/10.1021/ja069017t


21. Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., Melander, C. Mimicking the Biological Activity of Diazobenzo[b]fluorene Natural Products with Electronically Tuned Diazofluorene Analogs. Bioorganic and Medicinal Chemistry Letters, 2006, 16, (19), 5148-5151. doi.org/10.1016/j.bmcl.2006.07.024


20. Zeng, W., Ballard, T. E., Melander, C. Tuning the Oxidation Properties of Vanadium (V) Through Ligand Stoichiometry. Tetrahedron Letters 2006, 47, (33), 5923-5926. doi.org/10.1016/j.tetlet.2006.06.051


19. Burnet, R., Melander, C., Puckett, J. W., Son, L. S., Wells, R. D., Dervan, P. B., and Gottesfeld, J. G. DNA sequence-specific polyamides alleviate transcriptional inhibition associated with long GAA.TTC repeats in Friedreich’s ataxia. Proceedings of the National Academy of Science 2006, 103 (91), 11497-11502.  doi.org/10.1073/pnas.0604939103


18. Gearha, M. D., Dickinson, L., Ehley, J., Melander, C., Dervan, P. B., Wright, P. E., Gottesfeld, J. M. Inhibition of DNA Binding by Human Estrogen-Related Receptor 2 and Estrogen Receptor a with Minor Groove Binding Polyamides. Biochemistry 2005, 44 (11): 4196-4203.  doi.org/10.1021/bi047872o


17. Ylisastigui, L., Coull, J. J., Rucker, V. C., Melander, C., Bosch, R. J., Brodie, S. J., Corey, L., Sodora, D. L., Dervan, P. B., Margolis, D. M. Polyamides Reveal a Role for Repression in Latency within Resting T Cells of HIV-Infected Donors. Journal of Infectious Diseases 2004, 190, (8), 1429-1437. doi.org/10.1086/423822


16. Melander, C., Burnett, R., Gottesfeld, J. M. Regulation of Gene Expression with Pyrrole-Imidazole Polyamides. Journal of Biotechnology 2004, 112, (1-2), 195-220. doi.org/10.1016/j.jbiotec.2004.03.018


15. Dickinson, L. A., Burnett, R., Melander, C., Edelson, B. S., Arora, P. S., Dervan, P. B., Gottesfeld, J. M. Arresting Cancer Proliferation by Small-Molecule Gene Regulation. Chemistry & Biology 2004, 11, (11), 1583-1594. doi.org/10.1016/j.chembiol.2004.09.004


14. Suto, R. K., Edayathumangalam, R. S., White, C., Melander, C., Gottesfeld, J. M., Dervan, P. B., Luger, K. Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-Binding Ligands. Journal of Molecular Biology 2003, 326, (2), 371-380. doi.org/10.1016/S0022-2836(02)01407-9


13. Rucker, V. C., Melander, C., Dervan, P. B. Influence of beta-Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove. Helvetica Chimica Acta 2003, 86, (6), 1839-1851. doi.org/10.1002/hlca.200390148


12. Rucker, V. C., Foister, S., Melander, C., Dervan, P. B. Sequence Specific Fluorescence Detection of Double Strand DNA. Journal of The American Chemical Society 2003, 125, (5), 1195-1202. doi.org/10.1021/ja021011q


11. Dudouet, B., Burnett, R., Dickinson, L. A., Wood, M. R., Melander, C., Belitsky, J. M., Edelson, B., Wurtz, N., Briehn, C., Dervan, P. B., Gottesfeld, J. M. Accessibility of Nuclear Chromatin by DNA Binding Polyamides. Chemistry & Biology 2003, 10, (9), 859-867. doi.org/10.1016/j.chembiol.2003.09.001


10. Gottesfeld, J. M., Belitsky, J. M., Melander, C., Dervan, P. B., Luger, K. Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands. Journal of Molecular Biology 2002, 321, (2), 249-263. doi.org/10.1016/S0022-2836(02)00598-3


9. Ehley, J. A., Melander, C., Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides. Molecular and Cellular Biology 2002, 22, (6), 1723-1733. doi.org/10.1128/MCB.22.6.1723-1733.2002


8. Coull, J. J., He, G. C., Melander, C., Rucker, V. C., Dervan, P. B., Margolis, D. M. Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides. Journal of Virology 2002, 76, (23), 12349-12354.  doi.org/10.1128/JVI.76.23.12349-12354.2002


7. Gottesfeld, J. M., Melander, C., Suto, R., Raviol, H., Luger, K., Dervan, P. B. Sequence-Specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides. Journal of Molecular Biology 2001, 309, (3), 615-629. doi.org/10.1006/jmbi.2001.4694


6. Baliga, R., Baird, E. E., Herman, D. M., Melander, C., Dervan, P. B., Crothers, D. M. Kinetic Consequences of Covalent Linkage of DNA Binding Polyamides. Biochemistry 2001, 40, (1), 3-8. doi.org/10.1021/bi0022339


5. Melander, C., Herman, D. M., Dervan, P. B. Discrimination of A/T Sequences in the Minor Groove of DNA within a Cyclic Polyamide Motif. Chemistry-A European Journal 2000, 6, (24), 4487-4497. doi.org/10.1002/1521-3765(20001215)6:24<4487::AID-CHEM4487>3.0.CO;2-C


4. Melander, C., Horne, D. A. Mutarotation of Tetramethylglucose Catalyzed by Ribonucleosides. Tetrahedron Letters 1997, 38, (5), 713-716. doi.org/10.1016/S0040-4039(96)02422-7


3. Melander, C., Horne, D. A. Kinetic Analysis of Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Evidence of Bifunctional Catalysis. Journal of Organic Chemistry 1997, 62, (26), 9295-9297. doi.org/10.1021/jo971614y


2. Melander, C., Horne, D. A. Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Journal of Organic Chemistry 1996, 61, (23), 8344-8346. doi/pdfplus/10.1021/jo961331q


1. Kurth, M. J., Randall, L. A. A., Chen, C. X., Melander, C., Miller, R. B., Mcalister, K., Reitz, G., Kang, R., Nakatsu, T., Green, C. Library-Based Lead Compound Discovery-Antioxidants by an Analogous Synthesis Deconvolutive Assay Strategy. Journal of Organic Chemistry 1994, 59, (20), 5862-5864. doi.org/10.1021/jo00099a008