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Biomedical Image Contrast Agents

Scaled up the synthesis of nanoparticle contrast agents. I specialize in the synthesis of long emission lifetime, fluorescent and photoluminescent nanoparticles. This is achieved by modifying Au cores with fluorophore embedded shells or Au nanoclusters with tunable photoluminescence. Fluorescent silica particles with sizes ranging from 15 nm to 400 nm are also available. Such probes have been applied in tracking single molecules on live cells over the course of 12h and in super-resolution optical imaging.

  • Dual mode detectable probes include: Fluorescent/X-ray and Fluorescent/MRI

  • Triple Mode detectable probes include: Fluorescent/X-ray/MRI probes

  • Plasmonic, fluorescence, MRI, X-ray modalities of detection in a mouse animal model. Single mode and multi-mode detections

Representative Publications

Targeted X-ray contrast and fluorescent core-shell nanoparticles


Spectral CT Probes