Research Focus Areas
Custom Synthesis of Metal/Porous Nanoparticles
Nanotoxicology
Biomedical Image Contrast Agents
Precision Nanoprobes
Molecular Nanotechnology
Custom Synthesis of Metal/Porous Nanoparticles
Standardized synthesis of Gold nanoparticles (nanoclusters, 5 nm, 10 nm, 16 nm) Silver nanoparticles (nanoclusters, 10 nm, 40 nm, 95 nm) Iron oxide nanoparticles (10 nm) Gadolinium oxide (5 nm, 10 nm) Hafnium oxide (5 nm, 10 nm) Microporous silica particles (15 nm, 50 nm, 100 nm, 400 nm) Other nanoparticles currently being optimized include …
Nanotoxicology
Nanotoxicity assessment is an integral part of designing biomedical probes. In vitro toxicity of nanoparticles is assessed using murine (L929) and human cell lines (HUVEC, RAW246.7). In vivo toxicity was assessed in zebrafish models, and in vivo biodistribution/blood pool kinetics was assessed in athymic and euthymic mouse models. Representative Publications …
Biomedical Image Contrast Agents
Scaled up the synthesis of nanoparticle contrast agents. I specialize in the synthesis of long emission lifetime, fluorescent and photoluminescent nanoparticles. This is achieved by modifying Au cores with fluorophore embedded shells or Au nanoclusters with tunable photoluminescence. Fluorescent silica particles with sizes ranging from 15 nm to 400 nm are also available. Such probes …
Precision Nanoprobes
Antibody-drug conjugates are emerging as a frontrunner in precision targeted therapeutics. However, this capability is still beyond the ability of most academic laboratories. The primary reason for this is the need to identify a precise binding site on the constant region of the antibody (Fc) for the drug molecule to be conjugated, while not affecting …
Molecular Nanotechnology
This is the current focus of my research. Utilizing anisotropic and hybrid nanoparticle architectures to introduce directionality in motion, precisely orienting targeting molecules and directed exertion of force by nanosystems. Anisotropic nanoparticles can be Janus hybrids or non-spherical nanoparticles and include rods, plates, prisms, and core-shells. This will lay the basis for nanomotors and nanomachines …
Invited Talk at the Innovation Sciences Seminar Series hosted at Rosalind Franklin University of Medicine and Science
I had a fantastic time visiting Rosalind Franklin University of Medicine and Science to speak at the Innovation Sciences Seminar Series hosted by the Center for Proteomics and Molecular Therapeutics (PMT) on February 12, 2026. It was a privilege to share my team’s work on “Label-Free Targeting of Therapeutics to Cancer Cells or Multi-Drug Resistant …
Our Lab at Notre Dame Receives Notice of Allowance for Novel Nanoparticle Immunotherapy Technology
The patent office has officially issued a Notice of Allowance for Application US 18/547,664, marking a significant step forward in the fight against cancer. The technology, developed by Prakash Nallathamby and the research team, introduces a novel approach utilizing “Bispecific bridge nanoparticles.” Bridging the Gap in Cancer Treatment Current challenges in cancer therapy often revolve …
NIH Funding Opportunities
- Notice of Change to Key Dates for RFA-NS-25-017 and RFA-NS-25-018: BRAIN Initiative Technologies for Recording and Modulation in the Nervous System. February 13, 2026Notice NOT-NS-26-005 from the NIH Guide for Grants and Contracts
- Notice of Extension of the Expiration Date for PAR-23-059 "National Cancer Institute Program Project Applications for the Years 2023, 2024, and 2025 (P01 Clinical Trial Optional)" February 12, 2026Notice NOT-CA-26-010 from the NIH Guide for Grants and Contracts
- Notice of Change to Key Dates for PAR-23-209, PAR-23-204, PAR-23-201 NEI Collaborative Clinical Vision Research Grants (UG1 Clinical Trial Required) February 10, 2026Notice NOT-EY-26-001 from the NIH Guide for Grants and Contracts
- Notice of NCI's Participation in PA-25-302, NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) February 10, 2026Notice NOT-CA-26-003 from the NIH Guide for Grants and Contracts
- NIH No Longer Requires Advanced Permission for Conference Grant Applications February 10, 2026Notice NOT-OD-26-040 from the NIH Guide for Grants and Contracts
- Correction to Guidance on Salary Limitation for Grants and Cooperative Agreements FY 2026 February 9, 2026Notice NOT-OD-26-038 from the NIH Guide for Grants and Contracts
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