Research Experience for Undergraduates
Announcements
Custom Synthesis of Metal/Porous Nanoparticles
Nanotoxicology
Biomedical Image Contrast Agents
Precision Nanoprobes
Molecular Nanotechnology
Custom Synthesis of Metal/Porous Nanoparticles
Standardized synthesis of Gold nanoparticles (nanoclusters, 5 nm, 10 nm, 16 nm) Silver nanoparticles (nanoclusters, 10 nm, 40 nm, 95 nm) Iron oxide nanoparticles (10 nm) Gadolinium oxide (5 nm, 10 nm) Hafnium oxide (5 nm, 10 nm) Microporous silica particles (15 nm, 50 nm, 100 nm, 400 nm) Other nanoparticles currently being optimized include …
Nanotoxicology
Nanotoxicity assessment is an integral part of designing biomedical probes. In vitro toxicity of nanoparticles is assessed using murine (L929) and human cell lines (HUVEC, RAW246.7). In vivo toxicity was assessed in zebrafish models, and in vivo biodistribution/blood pool kinetics was assessed in athymic and euthymic mouse models. Representative Publications …
Biomedical Image Contrast Agents
Scaled up the synthesis of nanoparticle contrast agents. I specialize in the synthesis of long emission lifetime, fluorescent and photoluminescent nanoparticles. This is achieved by modifying Au cores with fluorophore embedded shells or Au nanoclusters with tunable photoluminescence. Fluorescent silica particles with sizes ranging from 15 nm to 400 nm are also available. Such probes …
Precision Nanoprobes
Antibody-drug conjugates are emerging as a frontrunner in precision targeted therapeutics. However, this capability is still beyond the ability of most academic laboratories. The primary reason for this is the need to identify a precise binding site on the constant region of the antibody (Fc) for the drug molecule to be conjugated, while not affecting …
Molecular Nanotechnology
This is the current focus of my research. Utilizing anisotropic and hybrid nanoparticle architectures to introduce directionality in motion, precisely orienting targeting molecules and directed exertion of force by nanosystems. Anisotropic nanoparticles can be Janus hybrids or non-spherical nanoparticles and include rods, plates, prisms, and core-shells. This will lay the basis for nanomotors and nanomachines …
RIDING TO FIGHT KIDS’ CANCER
This September, I am taking part in the Great Cycle Challenge to fight kids’ cancer! Only 4% of the billions of dollars the government spends annually on cancer research is directed towards treating childhood cancer. Right now, cancer is the biggest killer of children from disease in the United States. Over 15,700 children are diagnosed …
Science Outlets are More Actively Promoting Novel Technologies to Address Antibiotic-Resistant Bacteria and Antibiotic-Stewardship
Excited that our novel approach to tackling antibiotic resistance is gaining well-deserved publicity! We need outside the box thinking to tackle this problem. Juliane Hopf #advanceddoagnosticsandtherapeutics #notredame #antibioticresistance #nanotechnology #nanoscaleadvances #pdnano #biomimetics #health #nanoparticles #nd https://phys.org/news/2020-01-tackling-antibiotic-resistance-phage-mimicking-antibacterial.html Tackling antibiotic resistance: Phage-mimicking antibacterial core-shell nanoparticles could help by Brandi Wampler, University of Notre Dame Nanoparticle. Credit: P Nallathamby …
NIH Funding Opportunities
- Notice of Special Interest: NIDCD Health Disparities and Inequities Research June 11, 2021Notice NOT-DC-21-003 from the NIH Guide for Grants and Contracts
- Notice of Special Interest: Temporal Bone Histological Tissue Scanning Equipment Supplement June 11, 2021Notice NOT-DC-21-004 from the NIH Guide for Grants and Contracts
- Notice of Updated AHRQ Policy for Late Application Submission for Active Peer Review or National Advisory Council Service June 11, 2021Notice NOT-HS-21-016 from the NIH Guide for Grants and Contracts
- Notice of Biospecimen Sharing Policy for the National Institute of Mental Health, Including Requirements for Induced Pluripotent Stem Cell Resource Development and Sharing June 11, 2021Notice NOT-MH-21-265 from the NIH Guide for Grants and Contracts
- NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R41/R42 Clinical Trial Optional) June 10, 2021Funding Opportunity RFA-AG-22-014 from the NIH Guide for Grants and Contracts. The goal of this Research and Entrepreneurial Development Immersion (REDI) Small Business Technology Transfer Research (STTR) Grant is to foster the career development of early career scientists with an interest in entrepreneurship by simultaneously supporting their entrepreneurial development and facilitating their transition to industry.
- NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R43/R44 Clinical Trial Optional) June 10, 2021Funding Opportunity RFA-AG-22-007 from the NIH Guide for Grants and Contracts. The goal of this Research and Entrepreneurial Development Immersion (REDI) Small Business Innovation Research (SBIR) Grant is to foster thecareer development of early-career scientists with an interest in entrepreneurship by simultaneously supporting their entrepreneurial development and facilitating their transition to industry.
- NIA Research and Entrepreneurial Development Immersion (REDI): Mentored Entrepreneurial Career Development Award (K01 Clinical Trial Not Allowed) June 10, 2021Funding Opportunity RFA-AG-22-004 from the NIH Guide for Grants and Contracts. The purpose of the NIA Research and Entrepreneurial Development Immersion (REDI): Mentored Entrepreneurial Career Development Award is to provide support and protected time (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research […]
- NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurship Enhancement Award (R25 Clinical Trial Not Allowed) June 10, 2021Funding Opportunity RFA-AG-22-003 from the NIH Guide for Grants and Contracts. The purpose of the Research and Entrepreneurial Development Immersion (REDI): NIA Entrepreneurship Enhancement Award (R25) is to promote the development of entrepreneurial training programs that are designed to broaden the skillset of graduate students and postdocs, as well as early career master's, Ph.D., and […]
- NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed) June 10, 2021Funding Opportunity PAR-21-244 from the NIH Guide for Grants and Contracts. The purpose of the NIDA Animal Genetics Program is to identify genetic, genomic, and molecular (epi)genetic variants that underlie: 1. Phenotypes associated with addictive behaviors and/or vulnerability to distinct stages along the substance use disorder (SUD) trajectory (e.g. initial/acute use, escalation of use, acquisition […]
- Promoting Bunyavirales Basic Science Research (R01 Clinical Trial Not Allowed) June 10, 2021Funding Opportunity RFA-AI-21-046 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate fundamental research of human disease-causing pathogens in the Bunyavirales order by supporting projects studying vector competence, virology, pathogenesis, and immunity.
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