Research Focus Areas
Custom Synthesis of Metal/Porous Nanoparticles
Nanotoxicology
Biomedical Image Contrast Agents
Precision Nanoprobes
Molecular Nanotechnology
Custom Synthesis of Metal/Porous Nanoparticles
Standardized synthesis of Gold nanoparticles (nanoclusters, 5 nm, 10 nm, 16 nm) Silver nanoparticles (nanoclusters, 10 nm, 40 nm, 95 nm) Iron oxide nanoparticles (10 nm) Gadolinium oxide (5 nm, 10 nm) Hafnium oxide (5 nm, 10 nm) Microporous silica particles (15 nm, 50 nm, 100 nm, 400 nm) Other nanoparticles currently being optimized include …
Nanotoxicology
Nanotoxicity assessment is an integral part of designing biomedical probes. In vitro toxicity of nanoparticles is assessed using murine (L929) and human cell lines (HUVEC, RAW246.7). In vivo toxicity was assessed in zebrafish models, and in vivo biodistribution/blood pool kinetics was assessed in athymic and euthymic mouse models. Representative Publications …
Biomedical Image Contrast Agents
Scaled up the synthesis of nanoparticle contrast agents. I specialize in the synthesis of long emission lifetime, fluorescent and photoluminescent nanoparticles. This is achieved by modifying Au cores with fluorophore embedded shells or Au nanoclusters with tunable photoluminescence. Fluorescent silica particles with sizes ranging from 15 nm to 400 nm are also available. Such probes …
Precision Nanoprobes
Antibody-drug conjugates are emerging as a frontrunner in precision targeted therapeutics. However, this capability is still beyond the ability of most academic laboratories. The primary reason for this is the need to identify a precise binding site on the constant region of the antibody (Fc) for the drug molecule to be conjugated, while not affecting …
Molecular Nanotechnology
This is the current focus of my research. Utilizing anisotropic and hybrid nanoparticle architectures to introduce directionality in motion, precisely orienting targeting molecules and directed exertion of force by nanosystems. Anisotropic nanoparticles can be Janus hybrids or non-spherical nanoparticles and include rods, plates, prisms, and core-shells. This will lay the basis for nanomotors and nanomachines …
Nallathamby Lab at the Society for Biomaterials/ Japanese Society for Biomaterials (Jan 8-10, 2022) Hawaii
Virtually presented our lab’s research on tackling two pressing problems in biomedical research at the Society for Biomaterials/ Japanese Society for Biomaterials joint Symposium in Honolulu, Hawaii. (January 8-10, 2022). I am presenting our research on broad-spectrum antibiotic-free antibacterials to combat multi-drug resistant bacterial infections. Oral Presentation Session: Session 1: Bioglasses/Ceramics/Other Hard Materials2:37 – 2:52 …
Excited to be Funded by the Institute for Precision Health’s Harvest Grant
The University of Notre Dame’s Institute for Precision Health (IPH) has awarded funding to researchers spanning multiple departments at the University, as well as to colleagues at partner schools. IPH awarded proposals with two types of funding: seed grants, which provide funding for high-risk, high-reward research ideas, and harvest grants, which help researchers expand on established projects or pursue …
NIH Funding Opportunities
- Notice of Special Interest (NOSI): Dissemination and Implementation Science for Cancer Prevention and Control in Low Resource Environments May 20, 2022Notice NOT-CA-22-038 from the NIH Guide for Grants and Contracts
- Notice of Special Interest: Tools to Enhance the Study of Prenatal and Pediatric Hydrocephalus May 20, 2022Notice NOT-NS-23-003 from the NIH Guide for Grants and Contracts
- Notice of Special Interest: Disease Mechanisms of Prenatal and Pediatric Hydrocephalus May 20, 2022Notice NOT-NS-23-004 from the NIH Guide for Grants and Contracts
- The NIH Office of Disease Prevention (ODP) Announces the Pathways to Prevention Workshop: Nutrition as Prevention for Improved Cancer Health Outcomes May 20, 2022Notice NOT-OD-22-138 from the NIH Guide for Grants and Contracts
- Notice of Change to Key Dates for RFA-OD-21-007 "INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Exploratory/Developmental Research Grant Award (R21 Clinical Trial Not Allowed)" May 20, 2022Notice NOT-OD-22-120 from the NIH Guide for Grants and Contracts
- Promoting Equity in Global Health Research May 20, 2022Notice NOT-TW-22-001 from the NIH Guide for Grants and Contracts
- Transgender People: Immunity, Prevention, and Treatment of HIV and STIs (R21 Clinical Trial Not Allowed) May 19, 2022Funding Opportunity PAR-22-186 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support hypothesis-generating research in transgender people with the objective of characterizing the biological and immunological impact of the interventions (hormones, drugs and surgical) used for gender reassignment and their impact on susceptibility to HIV […]
- Notice of Change to Number of Applications per Institution Allowed for PAR-20-153 "NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)" May 19, 2022Notice NOT-GM-22-037 from the NIH Guide for Grants and Contracts
- NINDS Interdisciplinary Team Science Grant (RM1 Clinical Trial Optional) May 18, 2022Funding Opportunity RFA-NS-22-036 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) is designed to support integrated efforts of three or more (up to six) PDs/PIs to pursue bold, impactful, and challenging research in any area within the scope of the NINDS mission. The research approach should be interdisciplinary in nature, […]
- Notice of Special Interest (NOSI): Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship Awards to Support Training in Research Related to Down Syndrome as Part of the INCLUDE Project May 18, 2022Notice NOT-OD-22-126 from the NIH Guide for Grants and Contracts
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