Research Focus Areas

We have two positions available for undergraduate researchers. If you want to do meaningful research in disruptive therapeutics, please get in touch at pnallath@nd.edu

Custom Synthesis of Metal/Porous Nanoparticles
Plasmonic nanoparticles include silver and gold. Metal oxides include iron and the lanthanide-series elements of gadolinium, cerium, and hafnium. Porous nanoparticles are silica-based or polymeric micelles.

Nanotoxicology
Assessing in vitro toxicity of nanoparticles on murine and human cell lines. In vivo toxicity was assessed in zebrafish models, and in vivo biodistribution was assessed in mouse models.

Biomedical Image Contrast Agents
Plasmonic, fluorescence, MRI, and X-ray modalities of detection in a mouse animal model. Single-mode and multi-mode detections.

Precision Nanoprobes
Antibody, affibody, biologics mediated targeting. Volume loaded therapeutics, photosensitizers and radiosensitizers. This is applicable to cancer biology and neurodegenerative disease studies.

Molecular Nanotechnology
Utilizing anisotropic and hybrid nanoparticle architectures to introduce directionality in motion, precisely orienting targeting molecules and directed exertion of force by nanosystems. Anisotropic nanoparticles can be ‘Janus’ hybrids or non-spherical nanoparticles and includes rods, plates, prisms, and core-shells.

Custom Synthesis of Metal/Porous Nanoparticles

Standardized synthesis of Gold nanoparticles (nanoclusters, 5 nm, 10 nm, 16 nm) Silver nanoparticles (nanoclusters, 10 nm, 40 nm, 95 nm) Iron oxide nanoparticles (10 nm) Gadolinium oxide (5 nm, 10 nm) Hafnium oxide (5 nm, 10 nm) Microporous silica particles (15 nm, 50 nm, 100 nm, 400 nm) Other nanoparticles currently being optimized include …

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Nanotoxicology

Nanotoxicity assessment is an integral part of designing biomedical probes. In vitro toxicity of nanoparticles is assessed using murine (L929) and human cell lines (HUVEC, RAW246.7). In vivo toxicity was assessed in zebrafish models, and in vivo biodistribution/blood pool kinetics was assessed in athymic and euthymic mouse models. Representative Publications           …

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Biomedical Image Contrast Agents

Scaled up the synthesis of nanoparticle contrast agents. I specialize in the synthesis of long emission lifetime, fluorescent and photoluminescent nanoparticles. This is achieved by modifying Au cores with fluorophore embedded shells or Au nanoclusters with tunable photoluminescence. Fluorescent silica particles with sizes ranging from 15 nm to 400 nm are also available. Such probes …

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Precision Nanoprobes

Antibody-drug conjugates are emerging as a frontrunner in precision targeted therapeutics. However, this capability is still beyond the ability of most academic laboratories. The primary reason for this is the need to identify a precise binding site on the constant region of the antibody (Fc) for the drug molecule to be conjugated, while not affecting …

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Molecular Nanotechnology

This is the current focus of my research. Utilizing anisotropic and hybrid nanoparticle architectures to introduce directionality in motion, precisely orienting targeting molecules and directed exertion of force by nanosystems. Anisotropic nanoparticles can be Janus hybrids or non-spherical nanoparticles and include rods, plates, prisms, and core-shells. This will lay the basis for nanomotors and nanomachines …

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RIDING TO FIGHT KIDS’ CANCER

This September, I am taking part in the Great Cycle Challenge to fight kids’ cancer! Only 4% of the billions of dollars the government spends annually on cancer research is directed towards treating childhood cancer. Right now, cancer is the biggest killer of children from disease in the United States. Over 15,700 children are diagnosed …

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Science Outlets are More Actively Promoting Novel Technologies to Address Antibiotic-Resistant Bacteria and Antibiotic-Stewardship

Excited that our novel approach to tackling antibiotic resistance is gaining well-deserved publicity! We need outside the box thinking to tackle this problem. Juliane Hopf #advanceddoagnosticsandtherapeutics #notredame #antibioticresistance #nanotechnology #nanoscaleadvances  #pdnano #biomimetics #health #nanoparticles #nd https://phys.org/news/2020-01-tackling-antibiotic-resistance-phage-mimicking-antibacterial.html Tackling antibiotic resistance: Phage-mimicking antibacterial core-shell nanoparticles could help by Brandi Wampler, University of Notre Dame Nanoparticle. Credit: P Nallathamby …

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