Category Archive: Biomedical Imaging

May 14

TechConnect 2018 an SBIR/STTR Haven

TechConnect #techconnect keeps getting better every year! Anaheim was a great location, with a good mix of entrepreneurs and investors! Looking forward to the next one in Boston in May 2019. I chaired a very engaging panel of experts who elaborated on the biggest problem facing the industrial production of uniform nanoparticles. I showcased Notre …

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May 01

CD133+ Cancer Stem Cells Role in Metastasis

Excited for the 2nd publication this year through collaborative efforts with Harper Cancer Research Institute’s Karen Dahl (Title: CD133 Promotes Adhesion to the Ovarian Cancer Metastatic Niche). I did the 3D confocal imaging that showed CD133+ ovarian cancer cells clearly penetrate the basal epithelial cells, pointing to metastatic potential of stem cell like cancer cells. Looking …

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Apr 01

MRS 2018 Spring Symposium,

I will be at MRS 2018 from April 1 to April 5 presenting my work on novel cancer therapeutics Title: Biocompatible, Radiotherapeutic Hafnium Oxide Nanoparticle Imaging Probes Prepared Using a Novel Templated Synthesis Abstract Control ID: # 2884959 Paper # NM05.01.05 Presentation Date: April 2, 2018 Presentation Time: 9:30 AM to 9:45 AM Location: PCC …

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Mar 06

6th Annual Advanced Diagnostics and Therapeutics (AD&T) Symposium – March 6, 2018

Undergraduate Research Assistant Margo Waters (Sophomore), at her first poster presentation. Margo synthesizes the anisotropic nanoparticles being used in the ongoing study looking into the applications of antimicrobial peptides@nanoparticles as surfactants on implant materials and medical devices. The project lead is Dr. Juliane Hopf and her undergraduate mentee is Veronica Kalwatjys. The work is in collaboration …

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Mar 05

Advancing Nanotechnology in Labs Across Notre Dame

2018 has been off to a good start. Please check out, “Super-resolution fluorescence microscopy by stepwise optical saturation” by Yide Zhang, P.D. Nallathamby, et al. I am proud to have supplied Yide with the fluorescent nanoparticle probes that he used in this proof of concept paper for a new super-resolution technique that he co-invented with …

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Nov 05

Dual Mode CT/Fluorescence Detectable Immunotargeted Nanoparticle Probes to Identify Self-Renewing Cancer Cells In Vivo

Statement of Purpose: The high mortality and poor prognosis for women diagnosed with ovarian cancer is mainly due to late diagnosis. Improved detection of primary tumors and recurring tumors after chemotherapy is, therefore, crucial to reduce ovarian cancer mortality and improve progression-free survival. However, current clinical screening and diagnostic imaging methods are limited by low …

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Oct 31

Cytocompatibility of Hafnium Oxide Nanoparticle Imaging Probes Prepared Using a Novel Templated Synthesis

This work will be presented at MRS 2018 and at SFB 2018 Statement of Purpose: Hafnium oxide (HfO2) with a k-edge of 50 keV is being explored as a clinical X-ray contrast agent. HfO2 NPs are also in clinical trials as radiosensitizers that induce immune action against tumor sites.   However, the unpredictable stability of commercially …

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Sep 03

Non-Sintered Metal Oxide Nanocrystals

Nanoparticles (NPs) due to their size scale being 1-100 nm, are characterized by a greater surface area per unit mass than the bulk phase of the same material, which makes NPs display chemical reactivity and physical properties that approach the atomic phase. NPs derived from lanthanides (e.g. gadolinium, europium, etc.)  in particular attract a lot …

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