Jan 29

Phage-Mimicking Antibacterial Nanoparticles Tackle Group A Streptococcal Infections In Vivo

We are excited to publish on our Phage-mimicking nanoparticles efficiently tackling Group A Streptococcus infections in mouse wound infection models in RSC Nanoscale Advances (https://pubs.rsc.org/en/content/articlepdf/2024/NA/D3NA00620D). Thank you to Prof. Frank Castellino, Prof. Victoria Ploplis, and Deborah Donahue of the W.M. Keck Transgene Center for the in vivo studies. Thanks to Prof. Shaun Lee’s lab (Biology) for sharing their antimicrobial peptide library with us. This was truly a team effort by the technical staff and undergraduate researchers with the graduate student (Johanna Olesk) to get the data necessary to publish this work. The Indiana-CTSI project development team fund initiated this collaboration. The work was sustained by the Berthiaume Institute for Precision Health funding and the American Cancer Society’s Institutional Research Grant. This work highlights the quality research contributions made by Notre Dame Undergraduates. Conor Sheehan, Kevin Armknecht, and Zach Bennett are all undergraduate researchers. Conor Sheehan (NURF’22) and Kevin Armknecht (NURF’23) had summer undergraduate research fellowships from NDNnano. Johanna Olesk (MS-BioE’23) had a Materials Science and Engineering Fellowship in 2023. We are thankful for the support from BIPH UNDresearch and CTSI Indiana for bringing this publication to fruition. Congratulations to all the authors for this fantastic work.