Our manuscript titled, “PLGA nanoparticles formulations loaded with antibiotics induce sustained and controlled antibiotics release for prolonged antibacterial action against MRSA, and Pseudomonas aeruginosa FRD1” (MILMED-D-23-00750R1), has been accepted for publication. This is the first time we are publishing in the supplement to the Military Health Sciences Research Symposium. The manuscript was based on our poster presentation in MHSRS 2023. The manuscript is expected to be published online in August 2024. The lead author is Argerie Guevara (NURF 2021), and 2nd author is Kevin Armknecht (NURF 2022). This is Kevin’s 2nd publication from our group.
Our manuscript titled, “PLGA nanoparticles formulations loaded with antibiotics induce sustained and controlled antibiotics release for prolonged antibacterial action against MRSA, and Pseudomonas aeruginosa FRD1” (MILMED-D-23-00750R1), has been accepted for publication. This is the first time we are publishing in the supplement to the Military Health Sciences Research Symposium. The manuscript was based on our poster presentation in MHSRS 2023. The manuscript is expected to be published online in August 2024.
The purpose of the present study was to create resorbable nanoparticles (NPs) using poly(lactic-coglycolic
acid) (PLGA) to develop novel antibacterial therapeutics for treating chronic wound infections that are susceptible to recurrent infections. By first performing a release study, it was possible to predict the behavior of the different PLGA NP formulations and assess the efficacy of the nanocomposite drug delivery system. Overall, these PLGA NP formulations showed the potential of a burst release, followed by a sustained release of antibiotics from antibiotics-loaded PLGA NPs in a controlled manner. In the future, this can help prevent the emergence of recurrent infections in the treatment of chronic wounds and reduce the number of medical dressing changes.
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