The biggest bottle neck in Chimeric antigen receptor T-Cell (CAR-T cell) therapy is the 21 days it takes to expand the patient’s T cells before re-infusion into the patient’s blood. For many end-stage cancer patients the 21 day wait-period is a death sentence. We propose to explore a 3-part CAR-T cell therapy with only a 2 day wait time before start of therapy. Secondly, current state-of-the art in CAR-T cell technology is only effective against bloodborne malignancies (e.g. acute lymphoblastic leukemia). CAR-T cell clinical trials against solid malignancies has resulted in poor to fatal results. Reasons for the poor performance has been off-target activation, Tumor lysis syndrome (TLS), Cytokine release syndrome (CRS) and persistent “ON” state of cytotoxic CAR-T cells. Recent literature on the switchable CAR-T cell (sCAR-T-cell) system proposed by two research teams uses a small-molecule switch that has bispecific binding domains directed to the tumor and the sCAR-T cells to redirect the sCAR-T cells to the tumor site. However, at the ideal switch concentration no amelioration of the signs related to both CRS and TLS were observed in comparison to the suicide gene auto-destruct CAR T-cell strategy, with a daily or every other day administration. We propose to explore a non-genetic, quick off switch for the gCAR-T cells in order to reduce off target activation, CRS and TLS.
Aug 30
Nanoparticles that act as an “ON and OFF” switch to improve the safety and effectiveness of CAR-T cancer therapy
Categories:
AD&T Notre Dame, Berthiaume Institute for Precision Health, Combination chemotherapy, Harper Cancer Research Institute, Immunotherapy, metastatic cancer cells
by Prakash
Always thankful for the internal support from Notre Dame Research #notredameresearch for supporting high risk-high gain projects such as mine. Here’s hoping that my faculty research support program initiation grant (FRSP-IG) #FRSP will pave the way for safer, more accessible CAR-T therapies and better quality of life for patients.
Tags: NDNano
Recent Posts
- Phage-Mimicking Antibacterial Nanoparticles Tackle Group A Streptococcal Infections In Vivo January 29, 2024
- 2nd Annual Berthiaume Institute for Precision Health’s Advisory Board Meeting October 30, 2023
- 1st Place Poster at the Military Health Sciences Research Symposium 2023 (Aug 14-17, Kissimmee, FL) August 14, 2023
- Congratulations to Ms. Johanna Olesk on Defending her MS (Bioengineering) ’23 Thesis July 7, 2023
- Translational Science to Impact Public Health was our Goal at Techconnect 2023 June 17, 2023
Archives
Categories
NIH Funding Opportunities
- Notice of Correction to PAR-23-199 "ClinGen Curation Expert Panels (U24 Clinical Trials not Allowed)" June 28, 2024Notice NOT-HD-24-025 from the NIH Guide for Grants and Contracts
- Notice of Early Expiration and Reissuance of NOT-HL-22-039 "Notice of Special Interest (NOSI): Administrative Supplements to Support Programs for Inclusion and Diversity Among Individuals Engaged in Health-Related Research (PRIDE) Small Research Projects" June 28, 2024Notice NOT-HL-24-020 from the NIH Guide for Grants and Contracts
- NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Patient-Oriented Research Career Development award (K23 - Clinical Trial Required) June 28, 2024Funding Opportunity PAR-24-220 from the NIH Guide for Grants and Contracts. The purpose of this NIH HEAL Initiative PAINCare Clinician Training Program (PCTP): Mentored Patient-Oriented Research Career Development award (K23) (Clinical Trial Required) is to support a cohort of new and well-trained, independent investigators. The program will provide independent NIH research support during the early-career […]
- NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Not Allowed) June 28, 2024Funding Opportunity PAR-24-219 from the NIH Guide for Grants and Contracts. The purpose of this NIH HEAL Initiative PAINCare Clinician Training Program: PCTP): Mentored Clinical Scientist Development Awards (K08) (Clinical Trials Not Allowed)is to support a cohort of new and well-trained, independent investigators. The program will provide independent NIH research support during the early-career phase […]
- NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Basic Experimental Studies with Humans (BESH) Required) June 28, 2024Funding Opportunity PAR-24-218 from the NIH Guide for Grants and Contracts. The purpose of this NIH HEAL Initiative PAINCare Clinician Training Program(PCTP): Mentored Clinical Scientist Development Awards (K08) (BESH)is to support a cohort of new and well-trained, independent investigators. The program will provide independent NIH research support during the early-career phase to help awardeesestablish independent […]
- Notice of Special Interest (NOSI): Epigenetic Modulation of HBV cccDNA and integrated HBV DNA (iDNA): Implications for Epigenetic Treatment Strategies Against HBV in HIV/HBV Co-Infection June 28, 2024Notice NOT-AI-24-050 from the NIH Guide for Grants and Contracts
- Notice of Intent to Publish a Funding Opportunity Announcement for Scaling-up and Maintaining Evidence-based Interventions to Maximize Impact on Cancer (SUMMIT) - Tobacco Use Treatment for Cancer Survivors (UG3/UH3 Clinical Trial Required) June 27, 2024Notice NOT-CA-24-076 from the NIH Guide for Grants and Contracts
- NIMH Research Education Mentoring Program for HIV Researchers (R25 Clinical Trial Not Allowed) June 27, 2024Funding Opportunity PAR-24-233 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this National Institute of Mental Health (NIMH) R25 program is to support educational activities that complement and/or enhance the training of a workforce […]
- NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required) June 27, 2024Funding Opportunity PAR-24-217 from the NIH Guide for Grants and Contracts. The purpose of this NIH HEAL Initiative PAIN Care Clinician Training Program: PCTP): Mentored Clinical Scientist Development Awards (K08) (Clinical Trials Required) is to support a cohort of new and well-trained, independent investigators. The program will provide independent NIH research support during the early-career […]
- Notice of Special Interest (NOSI): Discovery and Development of Oral Small-molecule Direct-acting Antivirals Targeting Viruses of Pandemic Potential June 27, 2024Notice NOT-AI-24-053 from the NIH Guide for Grants and Contracts
Recent Comments