The biggest bottle neck in Chimeric antigen receptor T-Cell (CAR-T cell) therapy is the 21 days it takes to expand the patient’s T cells before re-infusion into the patient’s blood. For many end-stage cancer patients the 21 day wait-period is a death sentence. We propose to explore a 3-part CAR-T cell therapy with only a 2 day wait time before start of therapy. Secondly, current state-of-the art in CAR-T cell technology is only effective against bloodborne malignancies (e.g. acute lymphoblastic leukemia). CAR-T cell clinical trials against solid malignancies has resulted in poor to fatal results. Reasons for the poor performance has been off-target activation, Tumor lysis syndrome (TLS), Cytokine release syndrome (CRS) and persistent “ON” state of cytotoxic CAR-T cells. Recent literature on the switchable CAR-T cell (sCAR-T-cell) system proposed by two research teams uses a small-molecule switch that has bispecific binding domains directed to the tumor and the sCAR-T cells to redirect the sCAR-T cells to the tumor site. However, at the ideal switch concentration no amelioration of the signs related to both CRS and TLS were observed in comparison to the suicide gene auto-destruct CAR T-cell strategy, with a daily or every other day administration. We propose to explore a non-genetic, quick off switch for the gCAR-T cells in order to reduce off target activation, CRS and TLS.
Aug 30
Nanoparticles that act as an “ON and OFF” switch to improve the safety and effectiveness of CAR-T cancer therapy
Categories:
AD&T Notre Dame, Berthiaume Institute for Precision Health, Combination chemotherapy, Harper Cancer Research Institute, Immunotherapy, metastatic cancer cells
by Prakash
Always thankful for the internal support from Notre Dame Research #notredameresearch for supporting high risk-high gain projects such as mine. Here’s hoping that my faculty research support program initiation grant (FRSP-IG) #FRSP will pave the way for safer, more accessible CAR-T therapies and better quality of life for patients.
Tags: NDNano
Recent Posts
- Military Health Sciences Research Symposium 2024. (Aug 26-29, 2024, Kissimmee FL) August 30, 2024
- Sustained and Controlled Antibiotics Release for Prolonged Antibacterial Action Against MRSA, and Pseudomonas aeruginosa August 21, 2024
- Precision Health and Diagnostics Session Chair at Techconnect World Innovation Conference (2024) June 19, 2024
- MTEC Annual meeting in Baltimore MD (May 24, 2024) May 24, 2024
- Nallathamby Lab’s Kevin Armknecht is Invited to Present at the Midwest Microscopy and Microanalysis Workshop 2024 May 7, 2024
Archives
Categories
NIH Funding Opportunities
- Notice to Clarify the Disciplinary Scope and Increase Maximum Training Related Expenses for the Trans-Departmental Basic Biomedical Sciences (TBB) Program Area of the NIGMS Predoctoral Basic Biomedical Sciences Research Training Program July 3, 2025Notice NOT-GM-25-025 from the NIH Guide for Grants and Contracts
- Notice of Participation in PAR-25-331 (R21) and PAR-25-332 (R01), Research on Current Topics in Alzheimer's Disease and Its Related Dementias (Clinical Trial Optional) July 3, 2025Notice NOT-DE-25-046 from the NIH Guide for Grants and Contracts
- Notice of Participation in PAR-24-258, "Research Resource for Human Organs and Tissues (U42 Clinical Trial Not Allowed)" July 3, 2025Notice NOT-DC-25-030 from the NIH Guide for Grants and Contracts
- Extramural Loan Repayment Program for Contraception and Infertility Research (LRP-CIR) July 1, 2025Notice NOT-OD-25-096 from the NIH Guide for Grants and Contracts
- Extramural Loan Repayment Program for Clinical Researchers from Disadvantaged Backgrounds (LRP-CRDB) July 1, 2025Notice NOT-OD-25-095 from the NIH Guide for Grants and Contracts
- Extramural Loan Repayment Program for Research in Emerging Areas Critical to Human Health (LRP-REACH) July 1, 2025Notice NOT-OD-25-094 from the NIH Guide for Grants and Contracts
- Extramural Loan Repayment Program for Health Disparities Research (LRP-HDR) July 1, 2025Notice NOT-OD-25-093 from the NIH Guide for Grants and Contracts
- Extramural Loan Repayment Program for Pediatric Research (LRP-PR) July 1, 2025Notice NOT-OD-25-092 from the NIH Guide for Grants and Contracts
- Extramural Loan Repayment Program for Clinical Researchers (LRP-CR) July 1, 2025Notice NOT-OD-25-091 from the NIH Guide for Grants and Contracts
- Notice of NIAAA Participation in PAR-25-354 "Multidisciplinary Studies of HIV/AIDS and Aging (R01 Clinical Trial Optional)" June 30, 2025Notice NOT-AA-25-017 from the NIH Guide for Grants and Contracts
Recent Comments